|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 2 | Role of vitamins in gastrointestinal diseases显示文摘A tremendous amount of data from research was published over the past decades concerning the roles of different vitamins in various gastrointestinal diseases.For instance,most vitamins showed an inverse relationship with the risk of colorectal carcinoma as well as other malignancies like gastric and esophageal cancer in observational trials,however interventional trials failed to prove a clear beneficial preventive role.On the other hand,more solid evidence was obtained from high quality studies for a role of certain vitamins in specific entities.Examples for this include the therapeutic role of vitamin E in patients with nonalcoholic steatohepatitis,the additive role of vitamins B12 and D to the standard therapy of chronic hepatitis C virus,the role of vitamin C in reducing the risk of gallstones,the positive outcome with vitamin B12 in patients with aphthous stomatitis,and the beneficial effect of vitamin D and B1 in patients with inflammatory bowel disease.Other potential uses are yet to be elaborated,like those on celiac disease,pancreatic cancer,pancreatitis,cholestasis and other potential fields.Data from several ongoing interventional trials are expected to add to the current knowledge over the coming few years.Given that vitamin supplementation is psychologically accepted by patients as a natural compound with relative safety and low cost,their use should be encouraged in the fields where positive data are available. | Omar A Masri Jean M Chalhoub Ala I Sharara | 2015 | World Journal of Gastroenterology2015，21，17： | 8 |
| 3 | Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation显示文摘AIM:To compare the efficacy and palatability of 4L polyethylene glycol electrolyte(PEG)plus sugar-free menthol candy(PEG+M)vs reduced-volume 2 L ascorbic acid-supplemented PEG(Asc PEG).METHODS:In a randomized controlled trial setting,ambulatory patients scheduled for elective colonoscopy were prospectively enrolled.Patients were randomized to receive either PEG+M or Asc PEG,both splitdosed with minimal dietary restriction.Palatability was assessed on a linear scale of 1 to 5(1=disgusting;5=tasty).Quality of preparation was scored by assignment-blinded endoscopists using the modified Aronchick and Ottawa scales.The main outcomes were the palatability and efficacy of the preparation.Secondary outcomes included patient willingness to retake the same preparation again in the future and completion of the prescribed preparation.RESULTS:Overall,200 patients were enrolled(100patients per arm).PEG+M was more palatable than Asc PEG(76%vs 62%,P=0.03).Completing the preparation was not different between study groups(91%PEG+M vs 86%Asc PEG,P=0.38)but more patients were willing to retake PEG+M(54%vs 40%respectively,P=0.047).There was no significant difference between PEG+M vs Asc PEG in adequate cleansing on both the modified Aronchick(82%vs77%,P=0.31)and the Ottawa scale(85%vs 74%,P=0.054).However,PEG+M was superior in the left colon on the Ottawa subsegmental score(score0-2:94%for PEG+M vs 81%for Asc PEG,P=0.005)and received significantly more excellent ratings than Asc PEG on the modified Aronchick scale(61%vs 43%,P=0.009).Both preparations performed less well in afternoon vs morning examinations(inadequate:29%vs 15.2%,P=0.02).CONCLUSION:4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acidPEG and is associated with a higher rate of excellentpreparations;Clinicaltrial.gov identifier:NCT01788709. | Ala I Sharara Ali H Harb Fayez S Sarkis Jean M Chalhoub Rami Badreddine Fadi H Mourad Mahmoud Othman Omar Masri | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 4 | Gastroduodenal artery aneurysm rupture in hospitalized patients:An overlooked diagnosis显示文摘Gastroduodenal artery(GDA) aneurysm rupture is a rare serious condition.The diagnosis requires a high level of suspicion with specif ic attention to warning signs.Early diagnosis can prevent fatal outcomes.In this report,we describe a case of GDA aneurysm rupture presenting as recurrent syncope and atypical back and abdominal discomfort.The rupture manifested as hemorrhagic shock.The diagnosis was made by computed tomography of the abdomen which showed acute peritoneal and retroperitoneal bleeding.Angiographic intervention failed to coil the GDA and surgery with arterial ligation was the def initive treatment. | Kassem Harris Michel Chalhoub Ashish Koirala | 2010 | World Journal of Gastrointestinal Surgery2010，2，9： | 2 |
| 5 | Shake table test of cylindral water tank in base isolated structures 显示文摘 | Chalhoub M S Kelly J M | 1990 | Journal of Structural Engineering ASCE1990，116，7： | 1 |
| 6 | Novel quality control methods in conjunction with chemometrics(multivariate analysis)for detecting honey authenticity显示文摘 | Arvanitoyannis I S Chalhoub C Gotsiou P | 2005 | Crit Rev Food Sci Nutr2005，45，3： | 1 |
| 7 | S6kl is not required for Pten -deficient neuronal hypertrophy显示文摘 | Chalhoub N Kozma SC Baker SJ | 2006 | Brain Res2006，1100，1： | 1 |
| 8 | A computer model of gluconeogenesis and lipid metabolism in the perfused liver显示文摘 | Chalhoub E Hanson RW Belovich JM | 2007 | Am J Physiol Endocrinol Metab2007，293，6： | 1 |
| 9 | The Use of Botox in the Treatment of Post Cardiac Surgery Paradoxical Vocal Cord Movement显示文摘 | Michel Chalhoub Kassem Harris Louis Sasso Ghada Bourjeily | 2011 | Heart Lung and Circulation2011，，9： | 1 |
| 10 | PTEN and the PI3-Kinase path- way inCancer显示文摘 | Chalhoub N Baker SJ | 2009 | Annu Rev Pathol2009，4，1： | 1 |
| 11 | Whole genome sequencing identifies a novel occludin mutation in microcephaly with band-like calcification and polymicrogyria that extends the phenotypic spectrum显示文摘 | Elsaid MF Kamel H Chalhoub N | | 0，，： | 1 |
| 12 | PTEN and the PI3-kinase pathway in cancer显示文摘 | Chalhoub N Baker S J | 2009 | Annu Rev Pathol2009，4，： | 1 |
| 13 | Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing 显示文摘 | Bourjeily G Raker CA Chalhoub M | 2010 | Eur Respir2010，36，4： | 1 |
| 14 | Efficient cloning of plant genomes into bacterial artificial chromosome (BAC) libraries with larger and more uniform insert size显示文摘 | Chalhoub B Belcram H Caboche M | 2004 | Plant Biotechnol J2004，2，： | 1 |
| 15 | PTEN and the PI3-kinase pathway incancer显示文摘 | Chalhoub N Baker SJ | 2009 | Annu Rev Pathol2009，4，： | 1 |
| 16 | Lipoid pneumonia: a challenging diagnosis显示文摘 | Harris K Chalhoub M Maroun R | 2011 | Heart Lung2011，40，6： | 1 |
| 17 | Shake table test of cylindral water tank in base isolated structures显示文摘 | Chalhoub M S Kelly J M | 1990 | Journal of Structural Engineering ASCE1990，116，7： | 1 |
| 18 | Silver staining and recovery of AFLP amplification products on large denaturing polyacrylamide gels显示文摘 | Chalhoub B A Thibault S Laucou V | 1997 | Biotechniques1997，22，2： | 1 |
| 19 | Silver staining and recovery of AFLPTM amplification products on large denatureing Poluacrylamide gels显示文摘 | CHALHOUB BA THIBAULT S LAUCOU V RAMEAU C HOFTE H COUSIN R | 1997 | BioTechniques1997，22，2： | 1 |
| 20 | Silver staining and recovery of AFLP amplification products on large denaturing polyacrylamide gels 显示文摘 | CHALHOUB B A THIBAULT S LAUCOU V | 1997 | Biotechniques1997，22，21： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员