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9篇 您的检索式：作者名="Chalets D"

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		题名	作者	年代	出处	被引量
	1	Real-time performance simulation of marine diesel engines for the training of navy crews显示文摘	Chesse P Chalet D Tauzia X	2004	Marine Technology2004，41，3：	1
	2	Enhanced ascertainment of microchimerism using real-time quantitative polymerase chain reaction amplification of insertion-deletion polymorphisms 显示文摘	Lee TH Chalets D Reed W	2006	Transfusion2006，46，11：	1
	3	Real-time performance simulation of marine diesel engines for the training of navy crews显示文摘	CHESSE P CHALET D	2004	Marine Technology2004，41，3：	1
	4	Analysis of Unsteady Flow Through a Throttle Valve Using CFD 显示文摘	Chalet D Chesse P	2010	Engineering Applications of Computational Fluid Mechanics2010，4，3：	1
	5	Performance real-time performance simulation of marine diesel engines for the training of navy crews 显示文摘	Chesse P Chalet D Tauzia X	2004	Marine Technology and SNAME News2004，，3：	1
	6	Effect of a map width enhancement system on turbocharger centrifugal compressor performance and surge margin显示文摘	Mohtar H Chesse P Chalet D	2011	Proceedings of the Institution of Mechanical Engineers Part D:Journal of Automobile Engineering2011，225，3：	1
	7	Analysis of unsteady flow through a throttle valve using CFD显示文摘	Chalet D Chesse P	2010	Engineering Applications of Computational Fluid Mechanics2010，4，3：	1
	8	Emergence of cooperation and organization in an evolutionary game显示文摘	Chalet D Zhang Y C	1997	Physica A1997，246，：	1
	9	Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance显示文摘BACKGROUND Cardiac and hepatic functionality are intertwined in a multifaceted relationship.Pathologic processes involving one may affect the other through a variety of mechanisms,including hemodynamic and membrane transport effects.AIM To better understand the effect of extrahepatic cholestasis on regulations of membrane transporters involving digoxin and its implication for digoxin clearance.METHODS Twelve adult rats were included in this study;baseline hepatic and renal laboratory values and digoxin pharmacokinetic(PK)studies were established before evenly dividing them into two groups to undergo bile duct ligation(BDL)or a sham procedure.After 7 d repeat digoxin PK studies were completed and tissue samples were taken to determine the expressions of cell membrane transport proteins by quantitative western blot and real-time polymerase chain reaction.Data were analyzed using SigmaStat 3.5.Means between pre-surgery and post-surgery in the same experimental group were compared by paired t-test,while independent t-test was employed to compare the means between sham and BDL groups.RESULTS Digoxin clearance was decreased and liver function,but not renal function,was impaired in BDL rats.BDL resulted in significant up-regulation of multidrug resistance 1 expression in the liver and kidney and its down-regulation in the small intestine.Organic anion transporting polypeptides(OATP)1A4 was up-regulated in the liver but down-regulated in intestine after BDL.OATP4C1 expression was markedly increased in the kidney following BDL.CONCLUSION The results suggest that cell membrane transporters of digoxin are regulated during extrahepatic cholestasis.These regulations are favorable for increasing digoxin excretion in the kidney and decreasing its absorption from the intestine to compensate for reduced digoxin clearance due to cholestasis.	Parker Giroux Patrick B Kyle Chalet Tan Joseph D Edwards Michael J Nowicki Hua Liu	2022	World Journal of Gastrointestinal Pathophysiology2022，13，3：	0

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