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| 1 | Polymer coated nanodiamonds as gemcitabine prodrug with enzymatic sensitivity for pancreatic cancer treatment显示文摘The fabrication of Gemcitabine(GEM) prodrug was reported to be an effective method to enhance its pancreatic cancer treatment efficiency. Here, a kind of nanocarbon-based materials, nanodiamond(ND), was selected as the nanocarrier of GEM, owing to its outstanding surface properties and non-cytotoxicity. The polyelectrolytes,polyethyleneimine and polyacrylic acid, were used to self-assemble outside ND surface through electrostatic forces, followed by attachment of polyethylene glycol to address better biocompatibility. GEM was conjugated with an enzyme-sensitive peptide gly-phe-leu-gly to build up the controlled release platform. From characterization results of dynamic laser scattering, zeta potential and transmission electron microscope, the significant improvement of ND stability in physiological condition was proved. Non-cytotoxicity of this functionalized ND carriers and cytotoxicity of the prodrug against Bx PC-3 pancreatic cancer cells were indicated by methylthiazolyl tetrazolium(MTT) assay. In vivo experiments also revealed its superior anticancer effect compared with free GEM treatment. Therefore, the combination of polymer coated NDs with high surface capability and enzymeresponsive intracellular GEM release make it possible to realize higher treatment efficiency on pancreatic tumor therapy. | Wanying Ye Haijie Han Huan Li Qiao Jin Yuzhou Wu Sabyasachi Chakrabortty Tanja Weil Jian Ji | 2020 | Progress in Natural Science:Materials International2020，30，5： | 3 |
| 2 | Modelling of piping collapses and gully headcut landforms: Evaluating topographic variables from different types of DEM显示文摘The geomorphic studies are extremely dependent on the quality and spatial resolution of digital elevation model(DEM)data.The unique terrain characteristics of a particular landscape are derived from DEM,which are responsible for initiation and development of ephemeral gullies.As the topographic features of an area significantly influences on the erosive power of the water flow,it is an important task the extraction of terrain features from DEM to properly research gully erosion.Alongside,topography is highly correlated with other geo-environmental factors i.e.geology,climate,soil types,vegetation density and floristic composition,runoff generation,which ultimately influences on gully occurrences.Therefore,terrain morphometric attributes derived from DEM data are used in spatial prediction of gully erosion susceptibility(GES)mapping.In this study,remote sensing-Geographic information system(GIS)techniques coupled with machine learning(ML)methods has been used for GES mapping in the parts of Semnan province,Iran.Current research focuses on the comparison of predicted GES result by using three types of DEM i.e.Advanced Land Observation satellite(ALOS),ALOS World 3D-30 m(AW3D30)and Advanced Space borne Thermal Emission and Reflection Radiometer(ASTER)in different resolutions.For further progress of our research work,here we have used thirteen suitable geo-environmental gully erosion conditioning factors(GECFs)based on the multi-collinearity analysis.ML methods of conditional inference forests(Cforest),Cubist model and Elastic net model have been chosen for modelling GES accordingly.Variable’s importance of GECFs was measured through sensitivity analysis and result show that elevation is the most important factor for occurrences of gullies in the three aforementioned ML methods(Cforest=21.4,Cubist=19.65 and Elastic net=17.08),followed by lithology and slope.Validation of the model’s result was performed through area under curve(AUC)and other statistical indices.The validation result of AUC has shown that Cforest is the most appropriate model for predicting the GES assessment in three different DEMs(AUC value of Cforest in ALOS DEM is 0.994,AW3D30 DEM is 0.989 and ASTER DEM is 0.982)used in this study,followed by elastic net and cubist model.The output result of GES maps will be used by decision-makers for sustainable development of degraded land in this study area. | Alireza Arabameri Fatemeh Rezaie Subodh Chandra Pal Artemi Cerda Asish Saha Rabin Chakrabortty Saro Lee | 2021 | Geoscience Frontiers2021，12，6： | 2 |
| 3 | Incorporation of zirconium in medium-pore aluminophosphate molecular sieves with AEL framework 显示文摘 | GANGULI J N CHAKRABORTTY D SATYANARAYANA C V V | 2008 | Microporous and Mesoporous Materials2008，108，13： | 1 |
| 4 | Distribution and nature of organic matter in the surface soils of West Bengal 显示文摘 | Banerjee S K Chakrabortty A K | 1977 | Journal of the Indian Society of Soil Science1977，25，22： | 1 |
| 5 | Myofibroepithelial polyp of the ureter显示文摘 | Pal DK Sarkar K Chakrabortty D | 2014 | APSP J Case Rep2014，5，： | 1 |
| 6 | Intracerebral ring-enhancing lesions in a patient with multiple sclerosis:a case report显示文摘 | CHAKRABORTTY S NAGASHIMA T SAITOH M | 1995 | Surg Neurol1995，43，6： | 1 |
| 7 | Maffucci's syndrome associated with intracranial enchondroma and aneurysm:Case reporl显示文摘 | Chakrabortty S Tamaki N Kondoh T | 1991 | Surg Neurol1991，36，： | 1 |
| 8 | Removal of fluoride from contaminated groundwater by cross flow nanofiltration: Transport modeling and economic evaluation显示文摘 | Chakrabortty S Roy M Pal P | 2013 | Desal- ination2013，313，： | 1 |
| 9 | w <SUB>∞</SUB> 3-algebra显示文摘 | Shankhadeep Chakrabortty Alok Kumar Sachin Jain | 2008 | Journal of High Energy Physics2008，，09： | 1 |
| 10 | Estimation ofradial power system transfer path dynamic parameters us-ing synchronized phasor data显示文摘 | Chow J H Chakrabortty A Vanfretti hf | 2008 | IEEE Trans on Power Sys-tems2008，23，2： | 1 |
| 11 | Growth hormone producing pituitary adenomas MR characteristics and pre and postoperative evaluation显示文摘 | Chakrabortty S OiS Yamaguchi M | 1993 | Neurol Med Chir(Tokyo)1993，33，： | 1 |
| 12 | Choroid plexus epend ymal cells enhance neurite outgrowth from dorsal root ganglion neurons in vitro 显示文摘 | CHAKRABORTTY S MATSUMOTO N | 2000 | Neurocytol2000，29，： | 1 |
| 13 | Grafting of choroid plexus ependymal cells promotes the growth of regenerating axons in the dorsal funiculus of rat spinal cord:a preliminary report显示文摘 | Kitada M Chakrabortty S | 2001 | Exp Neurol2001，167，2： | 1 |
| 14 | Grafting of choroid plexus ependymal cells promotes the growth of regenerating axons in the dorsal funiculus of rat spinal cord: a preliminary report显示文摘 | Ide C Kitada M Chakrabortty S | 2001 | Exp Neurol2001，167，2： | 1 |
| 15 | A nanofiltration–coagulation integrated system for separation and stabilization of arsenic from groundwater显示文摘 | P. Pal S. Chakrabortty L. Linnanen | 2014 | Science of the Total Environment2014，，： | 1 |
| 16 | Maffuecis' syndrome associated with intracranial enehondroma and aneurysm : Case report显示文摘 | Chakrabortty S Tamaki N Kondoh T | 1991 | Surg Neuro1991，36，： | 1 |
| 17 | Growth hormone - producing pituitary adenomas:MR characteristics and pre - and postoperative evaluation 显示文摘 | Chakrabortty S Oi S Yamaguchi M | 1993 | Neurol Med Chir ( Tokyo )1993，33，： | 1 |
| 18 | Maffuccig syndrome associated with intracranial enchondroma and aneurysm:Case report显示文摘 | Chakrabortty S Tamaki N Kondoh T | 1991 | Sttrg Neurol1991，36，3： | 1 |
| 19 | Allelopathie effects of weeds on germination and seedling growth of tomato 显示文摘 | Sannigrahi A K Chakrabortty S | 2005 | Allelopathy Journal2005，16，2： | 1 |
| 20 | Synchronized phasor data based energy function analysis of dominant power transfer paths in large power systems显示文摘 | Chow J H Chakrabortty A Arcak M | 2007 | IEEE Trans on Power Systems2007，22，2： | 1 |
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