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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Propofol, bradycardia and the Bezold-Jarisch reflex in rabbits显示文摘 | Ma D Chakrabarti MK Whitwam JG | 1999 | Br J Anaesth1999，82，3： | 1 |
| 3 | Liquid-liquid two phase flow through a horizontal T- junction显示文摘 | PANDEY S GUPTA A CHAKRABARTI D P | 2006 | Chemical Engineering Research ~ De- sign2006，84，10： | 1 |
| 4 | Growth responses of marigold and salvia bedding plants as affected by monochromic or mixture radiation provided by a light emitting diode (LED) 显示文摘 | HEO J W LEE C W CHAKRABARTY D | 2002 | Plant Growth Regulation2002，38，3： | 1 |
| 5 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 6 | Detection of DNA methylation changes during somatic embryogenesis of Siberian ginseng( Eleuterococcus senticosus) 显示文摘 | Chakrabarty D Yu K W Paek K Y | 2003 | Plant Sci2003，165，： | 1 |
| 7 | Studies on morphology,mechanical,thermal,and rheological behavior of extrusion-blended polypropylene and thermotropic liquid crystalline polymer显示文摘 | P K Mandal D Bandyopadhyay D Chakrabarty | 2003 | Journal of Applied Polymer Science2003，88，： | 1 |
| 8 | Correlation between virulence and fusarie acid production in Fusarium oxysporum fsp carthami显示文摘 | Chakrabarti D K Basu Chaudhary K C | 1980 | Journal of Phytopathology1980，99，1： | 1 |
| 9 | Exopolysaccha- ride production in biofilms: substratum activation of alginate gene ex- pression by Pseudomonas aeruginosa显示文摘 | DAVIES D G CHAKRABARTY A M GEESEY G G | 1993 | Appl Environ Microbiol1993，59，4： | 1 |
| 10 | Effect of arsenic on growth, oxidative stress, and antioxidant system in rice seedlings 显示文摘 | SHRI M KUMAR S CHAKRABARTY D | 2009 | Ecotoxicology and Environmental Safety2009，72，： | 1 |
| 11 | Epidemic thresholds in real networks显示文摘 | CHAKRABARTI D WANG Yang WANG Chen-xi | 2008 | ACM Trans on Information Systems Security2008，10，4： | 1 |
| 12 | Numerical simulation of the performance of a sudden expansion with fence viewed as a diffuser in low Reynolds number regime显示文摘 | Chakrabarti S Rao S Mandal D K | 2010 | Journal of Engineering for Gas Turbines and Power2010，132，11： | 1 |
| 13 | Cross-polarization cancellation in an offset parabolic reflector antenna using a corrugated matched feed显示文摘 | Sharma S B Pujara D Chakrabarty S B | | 0，，： | 1 |
| 14 | Prevalence of snoring in college students显示文摘 | Patel M Trap D Chakrabarti A | 2008 | J Am CollHealth2008，57，1： | 1 |
| 15 | Improving the cross-polar performance of an offset parabolic reflector antenna using a rectangular matched feed显示文摘 | Sharma S B Pujara D Chakrabarty S B | | 0，，： | 1 |
| 16 | A review of the mam- malian unfolded protein response显示文摘 | Chakrabarti A Chen A W Varner J D | 2011 | Biotechnol Bioeng2011，108，： | 1 |
| 17 | Micropropagation of gerbera:Lipid peroxidation and antioxidant enzyme activities during acclimatization process显示文摘 | CHAKRABARTY D DATTA S K | 2008 | Physiol Plant2008，30，3： | 1 |
| 18 | Sprouting rate,change of carbohydrate contents and related enzymes during cold treatment of lily bulblets regenerated in vitro显示文摘 | SKIN K S CHAKRABARTY D PAEK K Y | 2002 | Scientia Horticulturae2002，96，14： | 1 |
| 19 | The use of fish community structure as a measure of ecological degradation : a case study in two tropical rivers of India显示文摘 | Das S K Chakrabarty D | 2007 | Biosystems2007，90，1： | 1 |
| 20 | Phase relations and precipitation in Al-Mg-Si alloys with Cu additions显示文摘 | Chakrabarti D J Laughlin D E | 2004 | Progress in Materials Science2004，49，34： | 1 |
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