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| 1 | The GEON service-oriented architecture for Earth Science applications显示文摘The Geosciences Network(GEON)project has been developing cyberinfrastructure for data sharing in the Earth Science community based on a serviceoriented architecture.The layered architecture consists of Core,Middleware,and Applications services.Core services provide system-level functions(e.g.user authentication),Middleware services provide generic capabilities(e.g.catalog search),and Application services provide functions that users directly interact with,including applications that are specific to Earth Sciences.The GEON‘service stack’includes a standardized set of these services and the corresponding software modules.The GEON Portal provides Web-based access to these services via a set of portlets.This service-oriented approach has enabled GEON to expand to new partner sites and leverage GEON services for other projects.To facilitate interoperation in a distributed geoinformatics environment,GEON is focusing on standards for distributed search across federated catalogs. | Chaitan Baru Sandeep Chandra Kai Lin Ashraf Memon Choonhan Youn | 2009 | International Journal of Digital Earth2009，2，S01： | 3 |
| 2 | Endoscopic fundoplication for the treatment of gastroesophageal reflux disease: Initial experience显示文摘 | Chaitan K. Narsule Miguel A. Burch Michael I. Ebright Donald T. Hess Roberto Rivas Benedict D.T. Daly Hiran C. Fernando | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，1： | 1 |
| 3 | TEAM Network: Building Web-based Data Access and Analysis Environments for Ecosystem Services显示文摘 | Choonhan Youn Sandeep Chandra Eric H. Fegraus Kai Lin Chaitan Baru | 2011 | Procedia Computer Science2011，，： | 1 |
| 4 | Biosynthesis of polyketide in heterologous hosts 显示文摘 | Blaine A Pfeifer Chaitan Khosla | 2001 | Microbiology and Molecular Biology Reviews2001，65，1： | 1 |
| 5 | A family of higher order mixed finite element methods for plane elasticity显示文摘 | Douglas N. Arnold Jim Douglas Chaitan P. Gupta | 1984 | Numerische Mathematik1984，，1： | 1 |
| 6 | Gupta,A generalized multi-point boundary value problem for second order ordinary differential equations显示文摘 | | 1998 | Mathematics and Computation1998，，89： | 1 |
| 7 | The Vitreoscilla hemoglobin gene: Molecular cloning, nucleotide sequence and genetic expression in Escherichia coli显示文摘 | Chaitan Khosla James E. Bailey | 1988 | MGG Molecular & General Genetics1988，，1： | 1 |
| 8 | Biosynthesis of polyketide in heterologous hosts显示文摘 | Blaine A Pfeifer Chaitan Khosla | 2001 | Microbiology and Molecular Biology Reviews2001，65，1： | 1 |
| 9 | Existence and Uniqueness Theorems for a Third-order Three-point Boundary Value Problems显示文摘 | Gupta V Lakshmikantham | 1991 | Nonlinear Analysis1991，16，： | 1 |
| 10 | Existence and Uniqueness Theorems for Three-point Boundary Value Problems显示文摘 | Chaitan P Gupta Jianming Xu | 1989 | Siam J Math Anal1989，22，： | 1 |
| 11 | Nonlinear Elliptic Boundary Value Problems in Lp-space and Sums of Ranges of Accretive Operators显示文摘 | Bruce D Calver Chaitan P Gupta | 1978 | Nonlinear Analysis Theory Methols & Applications1978，2，1： | 1 |
| 12 | Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease显示文摘 | Arnold Han Evan W. Newell Jacob Glanville Nielsen Fernandez-Becker Chaitan Khosla Yueh-hsiu Chien Mark M. Davis | 2013 | Proceedings of the National Academy of Sciences2013，，32： | 1 |
| 13 | A Dirichelet-Neumann mpoint BVP with a p-Laplacian-like operator显示文摘 | M Garcia-Huiobro Chaitan P Gupta R Manasevich | 2005 | Nonlinear Analysis2005，62，： | 1 |
| 14 | Characterization of the oxygendependent promoter of the Vitreoscilla hemoglobin gene in Escherichia coli显示文摘 | Chaitan K James E B | 1989 | Journal of Bacteriology1989，171，11： | 1 |
| 15 | Existence and uniqueness theorems for the bending of an elastic beam equation显示文摘 | Chaitan P. Gupta | 1988 | Applicable Analysis1988，，4： | 1 |
| 16 | Intracellular TG2 Activity Increases Microtubule Stability but is not Sufficient to Prompt Neurite Growth显示文摘Dear Editor,Microtubules(MTs)are the major cytoskeletal filaments in living cells.They are highly dynamic structures,and their assembly and disassembly are tightly regulated to achieve specific cellular functions.For example,MTs in the | Shunling Guo Brad A. Palanski Cornelius Kloeck Chaitan Khosla Bianxiao Cui | 2017 | Neuroscience Bulletin2017，33，1： | 0 |
| 17 | Fragment antigen binding domains (F_(ab)s) as tools to study assembly-line polyketide synthases显示文摘The crystallization of proteins remains a bottleneck in our fundamental understanding of their functions.Therefore,discovering tools that aid crystallization is crucial.In this review,the versatility of fragment-antigen binding domains(F_(ab)s)as protein crystallization chaperones is discussed.F_(ab)s have aided the crystallization of membrane-bound and soluble proteins as well as RNA.The ability to bind three F_(ab)s onto a single protein target has demonstrated their potential for crystallization of challenging proteins.We describe a high-throughput workflow for identifying F_(ab)s to aid the crystallization of a protein of interest(POI)by leveraging phage display technologies and differential scanning fluorimetry(DSF).This workflow has proven to be especially effective in our structural studies of assembly-line polyketide synthases(PKSs),which harbor flexible domains and assume transient conformations.PKSs are of interest to us due to their ability to synthesize an unusually broad range of medicinally relevant compounds.Despite years of research studying these megasynthases,their overall topology has remained elusive.One F ab in particular,1B2,has successfully enabled X-ray crystallographic and single particle cryo-electron microscopic(cryoEM)analyses of multiple modules from distinct assembly-line PKSs.Its use has not only facilitated multidomain protein crystallization but has also enhanced particle quality via cryoEM,thereby enabling the visualization of intact PKS modules at near-atomic(3–5Å)resolution.The identification of PKS-binding F_(ab)s can be expected to continue playing a key role in furthering our knowledge of polyketide biosynthesis on assembly-line PKSs. | Katarina M.Guzman Chaitan Khosla | 2022 | Synthetic and Systems Biotechnology2022，7，1： | 0 |
| 18 | Mediating among GeoSciML resources显示文摘Integration of data across multiple independently developed data sources can be challenging due to a variety of heterogeneities that exist across such systems.Data mediation technologies provide approaches for overcoming these heterogeneities.Standards such as Geoscience Markup Language can address some of the heterogeneity issues by providing schema standards which sources can adhere to.This article addresses the issue of semantic heterogeneity across information resources by using domain ontologies and registering schema elements and data values to such ontologies.Registering data to ontologies provides a powerful search and data integration capability across disparate geoscience information resources. | Chaitan Baru Kai Lin | 2009 | International Journal of Digital Earth2009，2，S01： | 0 |
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