|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Control of Grain Size and Weight by the OsMKKK10-OsM KK4-OsMAPK6 Signaling Pathway in Rice显示文摘谷物尺寸是在庄稼决定谷物产量的关键农学的特点之一。然而,在庄稼位于谷物尺寸控制下面的机制留下逃犯。这里,我们证明断然表明小径的 OsMKKK10-OsMKK4-OsMAPK6 在米饭调整谷物尺寸和重量。在米饭,当组成地活跃的 OsMKKK10 (CA-OsMKKK10 ) 的 overexpression 导致大、重的谷物,长圆锥花序,和高植物时, OsMKKK10 功能的损失导致小、轻的谷物,短圆锥花序,和半矮子植物。OsMKKK10 交往与并且 phosphorylates OsMKK4。我们识别了 OsMKK4 gain-of-function 异种(large11-1D )? 那生产大、重的谷物。OsMKK4 large11-1D 等位基因编码的 A227T 比 OsMKK4 举办更强壮的 kinase 活动。植物 overexpressing OsMKK4 (OsMKK4-DD ) 的一种组成地活跃的形式也生产大谷物。进一步生物化学、基因的分析表明 OsMKKK10, OsMKK4,和 OsMAPK6 在一条普通小径工作控制谷物尺寸。一起拿,我们的学习在米饭为谷物尺寸和重量的 OsMKKK10-OsMKK4-OsMAPK6 调停串联的控制建立一个重要基因、分子的框架。 | Ran Xu Penggen Duan Haiyue Yu Zhengkui Zhou Baolan Zhang Ruci Wang Jing Li Guozheng Zhang Shangshang Zhuang Jia Lyu Na Li Tuanyao Chai Zhixi Tian Shanguo Yao Yunhai Li | 2018 | Molecular Plant2018，11，6： | 33 |
| 2 | Effects of Different Tillage Systems on Soil Properties,Root Growth,Grain Yield,and Water Use Efficiency of Winter Wheat (Triticum aestivum L.) in Arid Northwest China显示文摘Studies on root development, soil physical properties, grain yield, and water-use efficiency are important for identifying suitable soil management practices for sustainable crop production. A field experiment was conducted from 2006 through 2008 in arid northwestern China to determine the effects of four tillage systems on soil properties, root development, water-use efficiency, and grain yield of winter wheat (Triticum aestivum L.). The cultivar Fan 13 was grown under four tillage systems:conventional tillage (CT) without wheat stubble, no-tillage without wheat stubble mulching (NT), no-tillage with wheat stubble standing (NTSS), and no-tillage with wheat stubble mulching (NTS). The soil bulk density (BD) under CT system increased gradually from sowing to harvest, but that in NT, NTSS, and NTS systems had little change. Compared to the CT system, the NTSS and NTS systems improved total soil water storage (0-150 cm) by 6.1-9.6 and 10.5- 15.3% before sowing, and by 2.2-8.9 and 13.0-15.1% after harvest, respectively. The NTSS and NTS systems also increased mean dry root weight density (DRWD) as compared to CT system. The NTS system significantly improved water-use efficiency by 17.2-17.5% and crop yield by 15.6-16.8%, and the NTSS system improved that by 7.8-9.6 and 7.0-12.8%, respectively, compared with the CT system. Our results suggested that Chinese farmers should consider adopting conservation tillage practices in arid northwestern China because of benefits to soil bulk density, water storage, root system, and winter wheat yield. | HUANG Gao-bao CHAI Qiang FENG Fu-xue YU Ai-zhong | 2012 | Journal of Integrative Agriculture2012，11，8： | 27 |
| 3 | Dextral strike-slip of Sanguankou-Niushoushan fault zone and extension of arc tectonic belt in the northeastern margin of the Tibet Plateau显示文摘Sanguankou-Niushoushan 差错(SGK-NSSF ) 的运动学的特征具有到弧的延期的理解的大意义在西藏高原的东北边缘的构造的带。用地调查和各种各样的数据收集方法,包括大规模地质的印射,典型地形学的测量,并且沉积阶层标明日期, SGK-NSSF 展出明显的右罢工滑倒特征并且因此不是一个左首的罢工滑倒差错,由以前的研究人员相信了,这被决定。这研究的结果证明地质的边界为古生代,中生代,和新生代时代都被差错右地打乱,与是类似的指责的排水量。在地志的效果的消除以后,差错的最大的罢工滑倒排水量被发现是 | LEI QiYun ZHANG PeiZhen ZHENG WenJun CHAI ChiZhang WANG WeiTao DU Peng YU JingXing | 2016 | Science China Earth Sciences2016，59，5： | 17 |
| 4 | Ge-Gen Decoction attenuates oxytocin-induced uterine contraction and writhing response: potential application in primary dysmenorrhea therapy显示文摘The uterine tetanic contraction and uterine artery blood flow reduction are possible reasons for primary dysmenorrhea(PD). In the present study, we aimed to evaluate the uterine relaxant effect and the influence on uterine artery blood velocity of Ge-Gen Decoction(GGD), a well-known Chinese herbal formula. In female ICR mice, uterine contraction was induced by oxytocin exposure following estradiol benzoate pretreatment, and the uterine artery blood velocity was detected by Doppler ultrasound. Histopathological examination of the uterine tissue samples were performed by H&E staining. Ex vivo studies demonstrated that oxytocin, posterior pituitary, or acetylcholine induced contractions in isolated mouse uterus. GGD inhibited both spontaneous and stimulated contractions. In vivo study demonstrated that GGD significantly reduced oxytocin-induced writhing responses with a maximal inhibition of 87%. Further study demonstrated that GGD normalized oxytocin-induced abnormalities of prostaglandins F_2 alpha(PGF_(2α)) and Ca^(2+) in mice. In addition, injection of oxytocin induced a decrease in uterine artery blood flow velocity. Pretreatment with GGD reversed the oxytocin response on blood flow velocity. Histopathological examination showed pretreatment with GGD alleviated inflammation and edema in the uterus when compared with the model group. Both ex vivo and in vivo results indicated that GGD possessed a significant spasmolytic effect on uterine tetanic contraction as well as improvement on uterine artery blood velocity which may involve PGF_(2α) and Ca^(2+) signaling, suggesting that GGD may have a clinic potential in PD therapy. | YANG Lu CHAI Cheng-Zhi YUE Xin-Yi YAN Yan KOU Jun-Ping CAO Zheng-Yu YU Bo-Yang | 2016 | Chinese Journal of Natural Medicines2016，14，2： | 17 |
| 5 | Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload显示文摘Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer's disease patients,resulting in neuronal death.This study investigated whether components extracted from the Chinese herbs epimedium herb,milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer's disease patients.An APPswe/PS1ΔE9 double transgenic mouse model of Alzheimer's disease was used.The intragastric administration of compounds from epimedium herb,milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema,increased the number of neurons,downregulated divalent metal transporter 1 expression,upregulated ferroportin 1 expression,and inhibited iron overload in the cerebral cortex of mice with Alzheimer's disease.These compounds reduced iron overload-induced impairment of the central nervous system,indicating a new strategy for developing novel drugs for the treatment of Alzheimer's disease. | Xian-hui Dong Jiang-tao Bai Wei-na Kong Xiao-ping He Peng Yan Tie-mei Shao Wen-guo Yu Xi-qing Chai Yan-hua Wu Cong Liu | 2015 | Neural Regeneration Research2015，10，5： | 14 |
| 6 | Multidrug-resistant Tuberculosis Burden among the New Tuberculosis Patients in Zhejiang Province: An Observational Study, 2009-2013显示文摘 | Ying Peng Song-Hua Chen Le Zhang Bin Chen Ming-Wu Zhang Tie-Niu He Fei Wang Cheng-Liang Chai Lin Zhou Yu Zhang Xiao-Meng Wang Zhongwei Jia | 2017 | Chinese Medical Journal2017，，17： | 13 |
| 7 | Compound of icariin,astragalus,and puerarin mitigates iron overload in the cerebral cortex of Alzheimer's disease mice显示文摘Increasing evidence indicates that disruption of normal iron homeostasis may contribute to pathological development of Alzheimer's disease.Icariin,astragalus,and puerarin have been shown to suppress iron overload in the cerebral cortex and improve spatial learning and memory disorders in Alzheimer's disease mice,although the underlying mechanism remains unclear.In the present study,APPswe/PS1ΔE9 transgenic mice were administered icariin,astragalus,and puerarin(120,80,and 80 mg/kg,respectively,once a day,for 3 months).Iron levels were detected by flame atomic absorption spectroscopy.Interleukin-1β,interleukin-6,and tumor necrosis factor-α levels were measured in the cerebral cortex by enzyme linked immunosorbent assay.Glutathione peroxidase and superoxide dismutase activity and malondialdehyde content were determined by colorimetry.Our results demonstrate that after treatment,iron levels and malondialdehyde content are decreased,while glutathione peroxidase and superoxide dismutase activities are increased.Further,interleukin-1β,interleukin-6,and tumor necrosis factor-α levels were reduced.These results confirm that compounds of icariin,astragalus,and puerarin may alleviate iron overload by reducing oxidative stress and the inflammatory response. | Yu Zhang Wei-Na Kong Xi-Qing Chai | 2018 | Neural Regeneration Research2018，13，4： | 12 |
| 8 | Pancreatic neuroendocrine tumors: biology, diagnosis, and treatment显示文摘Pancreatic neuroendocrine tumors (PNETs), a group of endocrine tumors arising in the pancreas, are among the most common neuroendocrine tumors. The genetic causes of familial and sporadic PNETs are somewhat understood, but their molecular pathogenesis remains unknown. Most PNETs are indolent but have malignant potential. The biological behavior of an individual PNET is unpredictable; higher tumor grade, lymph node and liver metastasis, and larger tumor size generally indicate a less favorable prognosis. Endocrine testing, imaging, and histological evidence are necessary to accurately diagnose PNETs. A 4-pronged aggressive treatment approach consisting of surgery, locoregional therapy, systemic therapy, and complication control has become popular in academic centers around the world. The optimal application of the multiple systemic therapeutic modalities is under development; efficacy, safety, availability, and cost should be considered when treating a specific patient. The clinical presentation, diagnosis, and treatment of specific types of PNETs and familial PNET syndromes, including the novel Mahvash disease, are summarized. | Cynthia Ro Wanxing Chai Victoria E.Yu Run Yu | 2013 | Chinese Journal of Cancer2013，32，6： | 10 |
| 9 | Study on the mechanism of copper-ammonia complex decomposition in struvite formation process and enhanced ammonia and copper removal显示文摘Heavy metals and ammonia are difficult to remove from wastewater,as they easily combine into refractory complexes.The struvite formation method(SFM) was applied for the complex decomposition and simultaneous removal of heavy metal and ammonia.The results indicated that ammonia deprivation by SFM was the key factor leading to the decomposition of the copper-ammonia complex ion.Ammonia was separated from solution as crystalline struvite,and the copper mainly co-precipitated as copper hydroxide together with struvite.Hydrogen bonding and electrostatic attraction were considered to be the main surface interactions between struvite and copper hydroxide.Hydrogen bonding was concluded to be the key factor leading to the co-precipitation.In addition,incorporation of copper ions into the struvite crystal also occurred during the treatment process. | Cong Peng Liyuan Chai Chongjian Tang Xiaobo Min Yuxia Song Chengshan Duan Cheng Yu | 2017 | Journal of Environmental Sciences2017，29，1： | 9 |
| 10 | Characterization of refuse landfill leachates of three different stages in landfill stabilization process显示文摘Landfill leachates with different ages(mature leachate,11 years;semi-mature leachate,5 years;fresh leachate,under operation) were collected from Laogang Refuse Landfill,Shanghai to characterize the colloid size distribution and variations of leachate.These leachates were separated using micro-filtration and ultra-filtration into specific size fractions,i.e.,suspended particles(SP)(>1.2μm) ,coarse colloids(CC)(1.2-0.45μm) ,fine colloids(FC)(0.45μm,5 kDa/1 kDa molecular weight(MW) ) ,and dissolved organic matters(DM,<5 kDa/1 kDa MW) .The specific colloids in each size fraction were quantified and characterized through chemical oxygen demands(COD) ,total solid(TS) ,pH,NH4+-N,total organic carbon(TOC) and fixed solid(FS) .It was found that COD,NH4+-N and TS in leachate decreased significantly over ages,while pH increased.The dissolved fractions(<5 kDa/1 kDa) dominated(over 50%) in three leachates in terms of COD,and the organic matter content in dissolved fraction of leachates decreased and the inorganic matter increased as the disposal time extended,with the TOC/COD ratio 30%-7%.Dissolved fractions decreased from 82%to 40%in terms of TOC as the disposal time extended,suggested that the organic matter remained in leachate would form into middle molecular weight substances during the degradation process. | LOU Ziyang DONG Bin CHAI Xiaoli SONG Yu ZHAO Youcai ZHU Nanwen | 2009 | Journal of Environmental Sciences2009，21，9： | 9 |
| 11 | Experimental and numerical study of chaff cloud kinetic performance under impact of high speed airflow显示文摘To solve the kinetic and diffusion problem of surface-type infrared decoy, multi-chaff kinetic models are established and chaff cloud holistic kinetic performance are analyzed under the impact of high speed airflow in this work. Chaffs rotate rapidly during the motion under the impact of high speed airflow. The rotation speed is correlated with lift, position of pressure center and aerodynamic damping. Computational Fluid Dynamics(CFD) is used to compute the aerodynamic coefficients of chaff. It is found that there exists serious aerodynamic interference which mainly relates to the overlapping area and distance among chaffs during the diffusion of chaff cloud. The chaff wind tunnel test and rocket sled experiment are carried out to verify the credibility of the models in this work. Then, the variation of chaff cloud expectation and extremum are analyzed to achieve the holistic kinetic and diffusing performance of chaff cloud. Simulation results demonstrate that the chaffs diffuse rapidly under the impact of high speed airflow and chaff cloud can be formed rapidly within 0.5 s. The shape of the chaff cloud is similar to cone that forms a certain angle with the horizontal plane and most chaffs focus on the second half. | Hesong HUANG Zhongxiang TONG Shijie CHAI Yu ZHANG | 2018 | Chinese Journal of Aeronautics2018，31，11： | 8 |
| 12 | Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling显示文摘瞄准:lipopolysaccharides (LPS ) 源于的积累的证据表演毁坏克否定的细菌能被吸收,导致触发全身的发炎和胰岛素抵抗的 endotoxemia。在我们检验了 metformin 是否稀释了 endotoxemia 的这研究,因此改进胰岛素在高脂肪的饮食发信号喂了 mice.Methods:老鼠被喂为 18 个星期到的一本高脂肪的食谱导致胰岛素抵抗。一个组老鼠与口头的 metformin 被对待(100 mg·为 4 个星期的 kg −1·d−1) 。另一个组与 LPS 被对待(50 μ g· kg −1·d−1, sc ) 为 5,天为 10 d 由口头的 metformin 列在后面。另外的二个组为 7 d 收到了抗菌素的联合或为 7 d 的抗菌素的联合分别地由口头的 metformin 列在后面 4 个星期。在肝和肌肉发信号的葡萄糖新陈代谢和胰岛素被评估,许多内脏细菌,内脏渗透和浆液 LPS 层次是 measured.Results:在高脂肪的喂的老鼠, metformin 在内脏恢复了紧密的连接蛋白质 occludin-1 层次,颠倒了提高的内脏渗透和浆液 LPS 层次,并且增加了许多有益的细菌乳杆菌和 Akkermansia muciniphila。Metformin 也增加了 PKB Ser473 和 AMPK T172 phosphorylation,减少的 MDA 内容和氧化还原作用敏感的 PTEN 蛋白质层次,激活抗氧化的 Nrf2 系统,并且增加了 Iκ Bα在老鼠的肝和肌肉。有外长的 LPS 的处理在葡萄糖新陈代谢,胰岛素在老鼠的肝和肌肉发信号和氧化应力上废除了 metformin 的有益的效果。有抗菌素的处理独自作为 metformin 生产了类似的效果。而且,抗菌素的有益的效果对 metformin.Conclusion 的那些上瘾:Metformin 管理稀释 endotoxemia 并且提高胰岛素在高脂肪的喂的老鼠发信号,它贡献它的反糖尿病的效果。 | Zi-yu ZHOU Li-wei REN Ping ZHAN Han-yan YANG Dan-dan CHAI Zhi-wen YU | 2016 | Acta Pharmacologica Sinica2016，37，8： | 7 |
| 13 | Multipoint optimization on fuel efficiency in conceptual design of wide-body aircraft显示文摘Aircraft conceptual design optimizations that maximize the performance at a design condition(single-point) may result in designs with unsatisfying off-design performance.To further improve aircraft efficiency under actual flight operations, there is a need to consider multiple flight conditions(multipoint) in aircraft conceptual design and optimization.A new strategy for multipoint optimizations in aircraft conceptual design is proposed in this paper.A wide-body aircraft is taken as an example for both single-point and multipoint optimizations with the objective of maximizing the specific hourly productivity.Boeing 787-8 flight data was used in the multipoint optimization to reflect the true objective function.The results show that the optimal design from the multipoint optimization has a 7.72% total specific hourly productivity increase of entire flight missions compared with that of the baseline aircraft, while the increase in the total specific hourly productivity from the single-point optimal design is only 5.73%.The differences between the results of single-point and multipoint optimizations indicate that there is a good option to further improve aircraft efficiency by considering actual flight conditions in aircraft conceptual design and optimization. | Xiao CHAI Xiongqing YU Yu WANG | 2018 | Chinese Journal of Aeronautics2018，31，1： | 7 |
| 14 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 15 | Vertical Distribution of Soil Carbon, Nitrogen, and Phosphorus in Typical Chinese Terrestrial Ecosystems显示文摘Characterization of the vertical distribution of soil organic carbon(C), nitrogen(N), and phosphorus(P) may improve our ability to accurately estimate soil C, N, and P storage. Based on a database of 21 354 records in 74 long-term monitoring plots from 2004 to 2013 in the Chinese Ecosystem Research Network(CERN), we built fitting functions to quantify the vertical distribution of soil C, N, and P(up to 100 cm depth) in the typical Chinese terrestrial ecosystems. The decrease of soil C, N, and P content with depth can be well fitted with various mathematical functions. The fitting functions differed greatly between artificial(agriculture) and natural(desert, forest, and grassland) ecosystems, and also differed with respect to soil C, N, and P content. In both the artificial and natural ecosystems, the best fitting functions were exponential functions for C, quadratic functions for N, and quadratic functions for P. Furthermore, the stoichiometric ratios of soil C, N, and P were ranked in descending order: grassland > forest > agriculture > desert, and were also associated with climate. This study is the first to build the fitting functions for the profile distribution of soil C, N, and P in China at a national scale. Our findings provide a scientific basis to accurately assess the storage of C, N, and P in soils at a large scale, especially for the integrative analysis of historical data. | CHAI Hua YU Guirui HE Nianpeng WEN Ding LI Jie FANG Jiangping | 2015 | Chinese Geographical Science2015，25，5： | 7 |
| 16 | Comparison of microwave assisted extraction with hot reflux extraction in acquirement and degradation of anthocyanin from powdered blueberry显示文摘Acquirement and degradation kinetics of anthocyanin from powdered blueberry were studied to analyze the degradation reason and improve the yield of anthocyanin under microwave assisted extraction(MAE)conditions.Hot reflux extraction(HRE)method was employed as a reference with MAE to discriminate the influences of the microwave irradiation under the same extraction temperature at 30℃-70℃.Ethanol was selected as extraction solvent.Microwave volumetric heating improves the diffusion and solubility of anthocyanin within powdered blueberry particles in the pre-heating period.The kinetic coefficients,in terms of delivery kinetic and diffusion kinetic,are lower in MAE than that in HRE.Four anthocyanins including delphinidin,cyanidin,malvidin and pelaronidin were detected in the anthocyanin extracts from blueberry.Delphinidin,cyaniding,and pelargonidin contents significantly decrease,but malvidin was unchanged in MAE.Anthocyanin yield increases with elevating extraction temperatures,but anthocyanin degradation occurred at 41.2℃.The acquirement amount of anthocyanin is lower than its degradation amount when microwave extraction temperature is higher than 53.6℃.The self-aggregation of anthocyanin molecules and degradation results in the reduction of anthocyanin yield extracted from blueberry powder.In MAE,microwave volumetric heating results in the rapidly elevated temperature in pre-heating stage and generation of internal pressure to improve the acquirement of anthocyanin and the non-thermal effect from microwave field may weak the effect of temperature to decline the degradation of anthocyanin to monomer.The non-thermal microwave irradiation has pronounced effects compared to the effects of temperature on the structure changes of anthocyanin molecules at extraction temperature below 50℃.In HRE,convection mode of heat transfer in extraction system form the non-uniform distribution of temperature in the extraction vials to decrease the acquirement yield of anthocyanin from the blueberry powder.The research results provide valuable data to optimize extraction temperature for high extraction yield and bioactivity of anthocyanin in microwave extraction process. | Sun Yu Xue Hongkun Liu Chenghai Liu Chai Su Xiaolin Zheng Xianzhe | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 7 |
| 17 | Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats显示文摘Amyloid β-peptide(Aβ) has been implicated as a key molecule in the neurodegenerative cascades of Alzheimer 's disease(AD). Humanin(HN) is a secretory peptide that inhibits the neurotoxicity of Aβ. However, the mechanism(s) by which HN exerts its neuroprotection against Aβ-induced ADlike pathological changes and memory deficits are yet to be completely defined. In the present study,we provided evidence that treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory deficits induced by Aβ1-42. HN also attenuated Aβ1-42-induced tau hyperphosphorylation,apparently by inhibiting the phosphorylation of Tyr307 on the inhibitory protein phosphatase-2A(PP2A)catalytic subunit and thereby activating PP2 A. HN also inhibited apoptosis and reduced the oxidativestress induced by Aβ1-42. These findings provide novel mechanisms of action for the ability of HN to protect against Aβ1-42-induced AD-like pathological changes and memory deficits. | Gao-Shang Chai Dong-Xiao Duan Rong-Hong Ma Jian-Ying Shen Hong-Lian Li Zhi-Wei Ma Yu Luo Lu Wang Xin-Hua Qi Qun Wang Jian-Zhi Wang Zelan Wei Darrell D.Mousseau Li Wang Gongping Liu | 2014 | Neuroscience Bulletin2014，30，6： | 7 |
| 18 | Lingbao Huxin Pill Alleviates Apoptosis and Inflammation at Infarct Border Zone through SIRT1-Mediated FOXO1 and NF-κB Pathways in Rat Model of Acute Myocardial Infarction显示文摘Objective To investigate whether Lingbao Huxin Pill(LBHX)protects against acute myocardial infarction(AMI)at the infarct border zone(IBZ)of myocardial tissue by regulating apoptosis and inflammation through the sirtuin 1(SIRT1)-mediated forkhead box protein O1(FOXO1)and nuclear factor-κB(NF-κB)signaling pathways.Methods Six-week-old Wistar rats with normal diet were randomized into the sham,the model,Betaloc(0.9 mg/kg daily),LBHX-L(0.45 mg/kg daily),LBHX-M(0.9 mg/kg daily),LBHX-H(1.8 mg/kg daily),and LBHX+EX527(0.9 mg/kg daily)groups according to the method of random number table,13 in each group.In this study,left anterior descending coronary artery(LADCA)ligation was performed to induce an AMI model in rats.The myocardial infarction area was examined using a 2,3,5-triphenyltetrazolium chloride solution staining assay.A TdT-mediated dUTP nick-end labeling(TUNEL)assay was conducted to assess cardiomyocyte apoptosis in the IBZ.The histopathology of myocardial tissue at the IBZ was assessed with Heidenhain,Masson and hematoxylineosin(HE)staining assays.The expression levels of tumor necrosis factorα(TNF-α),interleukin(IL)-6,IL-1β,and intercellular adhesion molecule-1 were measured using enzyme-linked immunosorbent assays(ELISAs).The mRNA expressions of SIRT1 and FOXO1 were detected by real-time qPCR(RT-qPCR).The protein expressions of SIRT1,FOXO1,SOD2,BAX and NF-κB p65 were detected by Western blot analysis.Results The ligation of the LADCA successfully induced an AMI model.The LBHX pretreatment reduced the infarct size in the AMI rats(P<0.01).The TUNEL assay revealed that LBHX inhibited cardiomyocyte apoptosis at the IBZ.Further,the histological examination showed that the LBHX pretreatment decreased the ischemic area of myocardial tissue(P<0.05),myocardial interstitial collagen deposition(P<0.05)and inflammation at the IBZ.The ELISA results indicated that LBHX decreased the serum levels of inflammatory cytokines in the AMI rats(P<0.05 or P<0.01).Furthermore,Western blot analysis revealed that the LBHX pretreatment upregulated the protein levels of SIRT1,FOXO1 and SOD2(P<0.05)and downregulated NF-κB p65 and BAX expressions(P<0.05).The RT-qPCR results showed that LBHX increased the SIRT1 mRNA and FOXO1 mRNA levels(P<0.05).These protective effects,including inhibiting apoptosis and alleviating inflammation in the IBZ,were partially abolished by EX527,an inhibitor of SIRT1.Conclusion LBHX could protect against AMI by suppressing apoptosis and inflammation in AMI rats and the SIRT1-mediated FOXO1 and NF-κB signaling pathways were involved in the cardioprotection effect of LBHX. | TAN Yu BIE Yu-long CHEN Li ZHAO Yi-han SONG Lei MIAO Li-na YU Yan-qiao CHAI Hua MA Xiao-juan SHI Da-zhuo | 2022 | Chinese Journal of Integrative Medicine2022，28，4： | 6 |
| 19 | Differentiation of Hepatocellular Carcinoma from Hepatic Hemangioma and Focal Nodular Hyperplasia using Computed Tomographic Spectral Imaging显示文摘Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary hepatic malignancy.This study was designed to investigate the value of computed tomography(CT)spectral imaging in differentiating HCC from hepatic hemangioma(HH)and focal nodular hyperplasia(FNH).Methods:This was a retrospective study of 51 patients who underwent spectral multiple-phase CT at 40–140 keV during the arterial phase(AP)and portal venous phase(PP).Slopes of the spectral curves,iodine density,water density derived from iodine-and water-based material decomposition images,iodine uptake ratio(IUR),normalized iodine concentration,and the ratio of iodine concentration in liver lesions between AP and PP were measured or calculated.Results:As energy level decreased,the CT values of HCC(n=31),HH(n=17),and FNH(n=7)increased in both AP and PP.There were significant differences in IUR in the AP,IUR in the PP,normalized iodine concentration in the AP,slope in the AP,and slope in the PP among HCC,HH,and FNH.The CT values in AP,IUR in the AP and PP,normalized iodine concentration in the AP,slope in the AP and PP had high sensitivity and specificity in differentiating HH and HCC from FNH.Quantitative CT spectral data had higher sensitivity and specificity than conventional qualitative CT image analysis during the combined phases.Conclusions:Mean CT values at low energy(40–90 keV)and quantitative analysis of CT spectral data(IUR in the AP)could be helpful in the differentiation of HCC,HH,and FNH. | Weixia Li Ruokun Li Xiangtian Zhao Xiaozhu Lin Yixing Yu Jing Zhang Kemin Chen Weimin Chai Fuhua Yan | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 6 |
| 20 | Design and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14a-demethylase(CYP51)显示文摘一系列 1-(1H-1,2,4-triazole-1-yl )-2-(2,4-difluorophenyl)-3-(N-isoproyl-N-substituted-amino)-2-propanols 根据 lanosterol 14a-demethylase (CYP51 ) 的活跃地点被设计了并且综合。他们的结构被 MS 和 1 H NMR。在 vitro,这些综合混合物的抗真菌的活动与八人的病原的真菌被作比较。结果证明所有标题混合物对测试到某程度的真菌展出了活动。混合物 3c, 3d, 7a, 7b 和 7c 展出了更多的有势力对将近除了曲霉属菌 fumigatus,真菌比 fluconazole 测试了的所有的抗真菌的活动。 | Zhi Gang Dan Jun Zhang Shi Chong Yu Hong Gang Hu Xiao Yun Chai Qing Yan Sun Qiu Ye Wu | 2009 | Chinese Chemical Letters2009，20，8： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员