|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparison of low back fusion techniques: transforaminal lumbar interbody fusion (TLIF) or posterior lumbar interbody fusion (PLIF) approaches显示文摘 | Chad D. Cole Todd D. McCall Meic H. Schmidt Andrew T. Dailey | 2009 | Current Reviews in Musculoskeletal Medicine2009，，2： | 1 |
| 2 | Comparison of low back fusion techniques: transformational lumbar interbody fusion (TLIF) or posterior lumbar inter- body fusion (PLIF) approaches显示文摘 | CHAD D COLE TIDD D MCCALl MEIC H SCHMIDT | 2009 | Curr Rev Museuloskelet Med2009，2，11： | 1 |
| 3 | Comparison of low back fusion techniques : transforaminal lumbar interbody fusion ( TLIF ) or posterior lumbar interbody fusion (PLIF) approaches 显示文摘 | Chad Cole Todd McCall Meic Schmidt el al | 2009 | Curr Rev Musculoskelet Med2009，2，2： | 1 |
| 4 | The Olecranon Osteotomy: A Six-year Experience in the Treatment of Intraarticular Fractures of the Distal Humerus显示文摘 | Chad P. Coles David P. Barei Sean E. Nork Lisa A. Taitsman Douglas P. Hanel M. Bradford Henley | 2006 | Journal of Orthopaedic Trauma2006，，3： | 1 |
| 5 | Comparison of low back fusion techniques:transforaminal lumbar interbody fusion(TLIF) or posterior lumbar interbody fusion(PLIF) approaches显示文摘 | Chad Cole Todd McCall Meic Schmidt | 2009 | Curr Rev Musculoskelet Med2009，2，2： | 1 |
| 6 | Application of the modified vaccination technique for the prevention and cure of chronic ailments显示文摘Over the years vaccination has proven to be the most successful health protection program for large populations,to prevent them from acquiring serious infectious and contagious diseases caused by exogenous antigens(ags) such as bacteria and viruses.Protection is generally achieved by an active immunization program,though passive immunization has also been employed, especially in the past,to combat diseases caused by certain bacterial infections(e.g.tetanus, diphtheria,etc.). Most recently,encouraging research data suggests that therapeutic approaches employing vaccination techniques can also be used to correct or deal with mishaps induced by or involving endogenous ags.However,most attempts at employing conventional vaccination techniques to do so have proven less than successful.In the case of cancer,one of the reasons for this is that the presentation of cancer related ags in presently available immunization frameworks is unable to evoke a powerful,specific cancer killing response.Therefore,drug treatments have been required in order to achieve additional beneficial effects. Recently,the Barabas group has developed a new vaccination technique(the third vaccination method,after active and passive immunization) called Modified Vaccination Technique(MVT). In experiments the MVT has been able to prevent-and with equal effectiveness,terminatemishaps induced by or involving endogenous ags,e.g.in an experimental autoimmune kidney disease called slowly progressive Heymann nephritis(SPHN). The MVT is safe,and is able to initiate a specific immune response in the injected host(provided the injected components are in pure form).The MVT promises to provide the next generation of vaccines for the prevention,treatment,and termination of chronic disorders in humans,such as autoimmune diseases,cancer,and chronic infections. | Arpad Z Barabas Chad D Cole Arpad D Barabas Richard M Graeff Rene Lafreniere Donald M Weir | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，2： | 0 |
| 7 | Intramedullary bone pedestal formation contributing to femoral shaft fracture nonunion:A case report and review of the literature显示文摘BACKGROUND Femoral shaft fracture is a commonly encountered orthopedic injury that can be treated operatively with a low overall delayed/nonunion rate.In the case of delayed union after antegrade or retrograde intramedullary nail fixation,fracture dynamization is often attempted first.Nonunion after dynamization has been shown to occur due to infection and other aseptic etiologies.We present a unique case of diaphyseal femoral shaft fracture nonunion after dynamization due to intramedullary cortical bone pedestal formation at the distal tip of the nail.CASE SUMMARY A 37-year-old male experienced a high-energy trauma to his left thigh after coming down hard during a motocross jump.Evaluation was consistent with an isolated,closed,left mid-shaft femur fracture.He was initially managed with reamed antegrade intramedullary nail fixation but had continued thigh pain.Radiographs at four months demonstrated no evidence of fracture union and failure of the distal locking screw,and dynamization by distal locking screw removal was performed.The patient continued to have pain eight months after the initial procedure and 4 mo after dynamization with serial radiographs continuing to demonstrate no evidence of fracture healing.The decision was made to proceed with exchange nailing for aseptic fracture nonunion.During the exchange procedure,an obstruction was encountered at the distal tip of the failed nail and was confirmed on magnified fluoroscopy to be a pedestal of cortical bone in the canal.The obstruction required further distal reaming.A longer and larger diameter exchange nail was placed without difficulty and without a distal locking screw to allow for dynamization at the fracture site.Post-operative radiographs showed proper fracture and hardware alignment.There was subsequently radiographic evidence of callus formation at one year with subsequent fracture consolidation and resolution of thigh pain at eighteen months.CONCLUSION The risk of fracture nonunion caused by intramedullary bone pedestal formation can be mitigated with the use of maximum length and diameter nails and close follow up. | Charles B Pasque Alexander J Pappas Chad A Cole Jr | 2022 | World Journal of Orthopedics2022，13，5： | 0 |
| 8 | SAR of tricyclic sulfones as γ-secretase inhibitors显示文摘Novel tricyclic sulfones as γ-secretase inhibitors have been reported by this laboratory for the treatment of Alzheimer's disease. Compounds in this series have comparable or better in vitro activities and in vivo efficacies than sulfonamide analogues re- ported previously by this laboratory. Based on the previously reported tricyclic sulfone scaffold, additional SAR studies of C ring were carried out. Various C-ring structures including cyclohexane, pyran, and piperidine were tolerated. Additionally, the 7- and 8- positions of the C-ring were identified as the best sites to introduce substituent for modulating the pharmacokinetic properties of compounds from this series. | COLE David ASBEROM Ted BARA Tom BENNETT Chad BURNETT Duane A. CLADER John DOMALSKI Martin GREENLEE William J. HYDE Lynn JOSIEN Hubert McBRIAR Mark McKITTRICK Brian PISSARNITSKI Dmitri RAJAGOPALAN Murali SASIKUMAR Thavalakulamgara | 2011 | Science China Chemistry2011，54，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员