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| 1 | CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells显示文摘Costimulatory signals are crucial for T cell activation. Attempts to block costimulatory pathways have been effective in preventing unwanted immune reactions. In particular, blocking the CD28/cytotoxic T lymphocyte antigen(CTLA)-4/B7 interaction(using CTLA-4Ig) and the CD40/CD40 L interaction(using anti-CD40 L antibodies) prevents T cell mediated autoimmune diseases, transplant rejection and graft vs host disease in experimental models. Moreover, CTLA-4Ig is in clinical use to treat rheumatoid arthritis(abatacept) and to prevent rejection of renal transplants(belatacept). Under certain experimental conditions, this treatment can even result in tolerance. Surprisingly, the underlying mechanisms of immune modulation are still not completely understood. We here discuss the evidence that costimulation blockade differentially affects effector T cells(Teff) and regulatory T cells(Treg). The latter are required to control inappropriate and unwanted immune responses, and their activity often contributes to tolerance induction and maintenance. Unfortunately, our knowledge on the costimulatory requirements of Treg cells is very limited. We therefore summarize the current understanding ofthe costimulatory requirements of Treg cells, and elaborate on the effect of anti-CD40 L antibody and CTLA-4Ig treatment on Treg cell activity. In this context, we point out that the outcome of a treatment aiming at blocking the CD28/CTLA-4/B7 costimulatory interaction can vary with dosing, timing and underlying immunopathology. | Isabel T Vogel Stefaan W Van Gool Jan L Ceuppens | 2014 | World Journal of Immunology2014，4，2： | 3 |
| 2 | Anti-tumor necrosis factor treatment restores the gut barrier in Crohn’s disease显示文摘 | Peter Suenaert Veerle Bulteel Liesbeth Lemmens Maja Noman Benny Geypens Gert Van Assche Karel Geboes Jan L Ceuppens Paul Rutgeerts | 2002 | The American Journal of Gastroenterology2002，，8： | 2 |
| 3 | Blocking B7 and CD40 costimulatory molecules decreases antiviral T cell activity显示文摘 | Vermeiren J Ceuppens JL Haegel-Kronenberger H | 2004 | Clin Exp Immunol2004，135，2： | 1 |
| 4 | Regulation of the immune response by prostaglandins显示文摘 | James S. Goodwin Jan Ceuppens | 1983 | Journal of Clinical Immunology1983，，： | 1 |
| 5 | Survival ofBacillus cereus Vegetative Cells and Spores during In VitroSimulation of Gastric Passage显示文摘 | Ceuppens S Uyttendaele M Drieskens K | 2012 | J Journal of Food Protection2012，75，4： | 1 |
| 6 | Bone morphogenetic proteins 2 and 6,expressed in arthritic synovium,are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis显示文摘 | Lories RJU Derese I Ceuppens JL | 2005 | Arthritis Rheum2005，48，10： | 1 |
| 7 | Western life style,local defenses and the rising incidence of allergic rhinitis显示文摘 | Ceuppens J | 2000 | Acta Otorhinlaryngol Belg2000，54，： | 1 |
| 8 | Western lifestyle,local defenses and the rising incidence of allergic rhinitis显示文摘 | Ceuppens J | 2000 | Acta Otorhinolaryngol Belg2000，54，3： | 1 |
| 9 | Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fi- broblast-like synoviocyte apoptosis显示文摘 | Lories RJ Derese I Ceuppens JL | 2003 | Arthritis Rheum2003，48，10： | 1 |
| 10 | Etanercept in the treatment of active refractory Crohn’s disease: a single-center pilot trial显示文摘 | Geert D’Haens Caroline Swijsen Maja Noman Liesbeth Lemmens Jan Ceuppens H Agbahiwe Karel Geboes Paul Rutgeerts | 2001 | The American Journal of Gastroenterology2001，，9： | 1 |
| 11 | TheWaldeyer's ring 显示文摘 | HELLINGS P JORISSEN M CEUPPENS J L | 2000 | Acta Otorhinolaryngol Belg2000，54，： | 1 |
| 12 | Diversity of Bacillus cereus group strains is reflected in their broad range of pathogenicity and diverse ecological lifestyles显示文摘 | Ceuppens S Boon N Uyttendaele M | 2013 | FEMS Microbiol Ecol2013，84，3： | 1 |
| 13 | The combination of anti-B7 monoclonal antibody and cyclosporin a induces alloantigen-specific anergy during a primary mix lymphocytes reaction 显示文摘 | de Boer M Ceuppens JL | 1994 | J Exp Med1994，179，2： | 1 |
| 14 | Cr- eate target and analyze this: New software assis- ting imaging mass spectrometry on Bruker Reflex IV and Ultraflex II instruments显示文摘 | CLERENS S CEUPPENS R ARCKENS L | 2006 | Rapid Com- munications in Mass Spectrometry2006，20，20： | 1 |
| 15 | Impact of non drained irrigated rice cropping on soil salinization in the Senegal River Delta显示文摘 | Ceuppens J Wopereis MCS | 1999 | Geo derma1999，92，： | 1 |
| 16 | Tile effects of physical exercise on the immune system 显示文摘 | Jeurissen A Bossuyt X Ceuppens JL | 2003 | Ned Tijdschr Geneeskd2003，147，28： | 1 |
| 17 | Microbiological quality and safety assessment of lettuce production in Brazil显示文摘 | CEUPPENS S HESSEL C T de QUADROS RODRIGLrES R | 2014 | International Journal of Food Microbiology2014，181，： | 1 |
| 18 | Microbiological quality and safety assessment of lettuce production in Brazil显示文摘 | Siele Ceuppens Claudia Titze Hessel Rochele de Quadros Rodrigues Sabrina Bartz Eduardo César Tondo Mieke Uyttendaele | 2014 | International Journal of Food Microbiology2014，，： | 1 |
| 19 | Local defenses and the rising incidence of allergic rhinitis显示文摘 | Ceuppens J Western lifestyle | 2000 | Acta Otorhinolaryngol Belg2000，54，5： | 1 |
| 20 | Combined asthma and alveolitis induced by cobalt in a di-amond polisher 显示文摘 | Van Cutsem E J Ceuppens JL Lacquer LM | 1987 | Eur J Respir Dis1987，70，1： | 1 |
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