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| 1 | Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats显示文摘 | Maria I. Bellissimo Débora Amado Dulcinéia S.P. Abdalla Edimar C. Ferreira Esper A. Cavalheiro Maria da Gra?a Naffah-Mazzacoratti | 2001 | Epilepsy Research2001，，2： | 1 |
| 2 | Changes in aminoacidergic and monoaminergic neurotransmission in the hippocampus and amygdala of rats after ayahuasca ingestion显示文摘AIM: To evaluate changes in neurotransmission induced by a psychoactive beverage ayahuasca in the hippocampus and amygdala of naive rats. METHODS: The level of monoamines, their main metabolites and amino acid neurotransmitters concentrations were quantified using high performance liquid chromatography(HPLC). Four groups of rats were employed: saline-treated and rats receiving 250, 500 and 800 mg/kg of ayahuasca infusion(gavage). Animals were killed 40 min after drug ingestion and the structures stored at-80 ℃ until HPLC assay. The data from all groups were compared using Analysis of variance and Scheffé as post test and P < 0.05 was accepted as significant. RESULTS: The results showed decreased concentrations of glycine(GLY)(0.13 ± 0.03 vs 0.29 ± 0.07, P < 0.001) and γ-aminobutyric acid(GABA)(1.07 ± 0.14 vs 1.73 ± 0.25, P < 0.001) in the amygdala of rats that received 500 of ayahuasca. Animals that ingested 800 mg/kg of ayahuasca also showed a reduction of GLY level(0.11 ± 0.01 vs 0.29 ± 0.07, P < 0.001) and GABA(0.98 ± 0.06 vs 1.73 ± 0.25, P < 0.001). In the hippocampus, increased GABA levels were found in rats that received all ayahuasca doses: 250 mg/kg(1.29 ± 0.19 vs 0.84 ± 0.21, P < 0.05); 500 mg/kg(2.23 ± 038 vs 084 ± 0.21, P < 0.05) and 800 mg/kg(1.98 ± 0.92 vs 0.84 ± 0.21, P < 0.05). In addition, an increased utilization rate of all monoamines was found in the amygdala after ayahuasca administration in doses: 250 mg/kg(noradrenaline: 0.16 ± 0.02 vs 0.36 ± 0.06, P < 0.01; dopamine: 0.39 ± 0.012 vs 2.39 ± 0.84, P < 0.001; serotonin: 1.02 ± 0.22 vs 4.04 ± 0.91, P < 0.001), 500 mg/kg(noradrenaline: 0.08 ± 0.02 vs 0.36 ± 0.06, P < 0.001; dopamine: 0.33 ± 0.19 vs 2.39 ± 0.84, P < 0.001; serotonin: 0.59 ± 0.08 vs 4.04 ± 0.91, P < 0.001) and 800 mg/kg(noradrenaline: 0.16 ± 0.04 vs 0.36 ± 0.06, P < 0.001; dopamine: 0.84 ± 0.65 vs2.39 ± 0.84, P < 0.05; serotonin: 0.36 ± 0.02 vs 4.04 ± 0.91, P < 0.001). CONCLUSION: Our data suggest increased release of inhibitory amino acids by the hippocampus and an increased utilization rate of monoamines by the amygdala after different doses of ayahuasca ingestion. | Eduardo Ferreira de Castro-Neto Rafael Henrique da Cunha Dartiu Xavier da Silveira Mauricio Yonamine Telma Luciana Furtado Gouveia Esper Abr o Cavalheiro Débora Amado Maria da Gra a Naffah-Mazzacoratti | 2013 | World Journal of Biological Chemistry2013，4，4： | 1 |
| 3 | Neuropeptide Y immunoreactivity in thepilocarpine model of temporal lobe epilepsy 显示文摘 | Cavalheiro FA | 1997 | Exp Brain Res1997，116，1： | 1 |
| 4 | Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine显示文摘 | Nasseh IE Amado D Cavalheiro EA | | 0，，： | 1 |
| 5 | The thermal behaviour of nickel,copper and zinc complexes with the Schiff bases cis-and trans-N,NO-bis(salicylidene)-1,2-ciclohexadiamine (Salcn)显示文摘 | Cavalheiro E T G Lemos F C D Schpector J Z | 2001 | Thermochimica Acta2001，370，12： | 1 |
| 6 | Estrogen effects on pilocarpine-induced temporal lobe epilepsy in rats显示文摘 | Pereira M Jr Soares JM Jr Valente SG Oliveira PB Cavalheiro EA Amado D Baracat EC | 2009 | Maturitas2009，62，2： | 1 |
| 7 | Effect of hormonal replacement therapy in the hippocampus of ovariectomized epileptic female rats using the pilocarpine experimental model显示文摘 | Valente SG Marques RH Baracat EC Cavalheiro EA Naffah-Mazzacoratti MG Amado D | 2008 | Epilepsy Res2008，82，1： | 1 |
| 8 | Evaluation of mucoadhesive gels with propolis (EPP-AF)in preclinical treatment of Candidiasis vulvovaginal infection显示文摘 | BERRETTA A A D E CASTRO P A CAVALHEIRO A H | | 0，，： | 1 |
| 9 | Optimization of acetion production by Hanseniaspora guilliermondii using experimental design显示文摘 | TEIXEIRA RM CAVALHEIRO D NINOW JL | 2002 | Brazil J Chem Eng2002，19，2： | 1 |
| 10 | Investigation of mitochondria involvement in theexperimental model of epilepsy induced by pilocarpine显示文摘 | Nasseh I E Amado D Cavalheiro E A | 2006 | Epilepsy Res2006，68，3： | 1 |
| 11 | Estrogen effects on pilocarpine-induced temporal lobe epilepsy in rats显示文摘 | Pereira M Jr Soares JM Jr Valente SG Oliveira PB Cavalheiro EA Amado D Baracat EC | 2009 | Maturitas2009，62，2： | 1 |
| 12 | The thermal behaviour of nickel,copper and zinc complexes with the Schiff bases cis-and trans-N,NO-bis(salicylidene)-1,2-ciclohexadiamine (Salcn)显示文摘 | Cavalheiro E T G Lemos F C D Schpector J Z | 2001 | Thermochimica Acta2001，370，12： | 1 |
| 13 | Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine 显示文摘 | Nasseh IE Amado D Cavalheiro EA | 2006 | Epilepsy Research2006，68，3： | 1 |
| 14 | Optimzation of acetoin production by Hanseniaspora guilliermondii using experimental design 显示文摘 | Teixeira R M Cavalheiro D Ninow J L | 2002 | Brazilian Journa of Chemical Engineering2002，19，2： | 1 |
| 15 | The thermal behaviour of nickel, copper and zinc complexes with the Schiff bases cis and trans-N, NO bis (salicylidene)-1, 2- ciclohexadiamine (Salen) 显示文摘 | Cavalheiro E T G Lemos F C D Schpector J Z | 2001 | Thermochimica Acta2001，370，12： | 1 |
| 16 | Poly (3-hydroxybutyrate) production by Cupriavidus necator using waste glyc erol显示文摘 | CAVALHEIRO J M B T ALMEIDA M C M D GRANDFILS C | 2009 | Process Biochem2009，44，： | 1 |
| 17 | Neuropeptide Y immunoreactivity in the piloc-arpine model of temporal lope epilepsy显示文摘 | Lurton D Cavalheiro FA | 1997 | Exp Brain Res1997，116，1： | 1 |
| 18 | Optimization of acetoin production by hanseniaspora guilliermondii using experimental design显示文摘 | Teixeira R M Cavalheiro D Ninow J L | 2002 | Brazilian Journal of Chemical Engineering2002，119，2： | 1 |
| 19 | Titanate nanotubes produced from microwave-assisted hydrothermal synthesis : Photocatalytic and structural properties 显示文摘 | Manfroi D C Dos Anjos A Cavalheiro A A | 2014 | Ceramics International2014，40，14： | 1 |
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