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| 1 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 2 | Endothehns as autocrine regulators of tumor cell growth显示文摘 | Bagnato A Cart K | 1998 | Tren&Endocrin Met1998，9，9： | 1 |
| 3 | Antitumor reactivity of anti-CD3/antiCD28 bead-activated lymphoid cells: implications for cell therapy in a murine model 显示文摘 | Ito F Cart A Svenssson H | 2003 | J Immunother2003，26，3： | 1 |
| 4 | Customer Re- purchase Intention: a General Structural Equation Model 显示文摘 | Hellier P K Geursen G M Cart R A | 2003 | European Journal of Marketing2003，37，1112： | 1 |
| 5 | Atherosclerotic plaque rupture in symptomatic carotid artery stenosis显示文摘 | Cart S Farb A Pearce WH | 1996 | J Vasc Surg1996，23，： | 1 |
| 6 | Control methods of inverter-interfaced distributed generators in a microgrid system显示文摘 | CHUNG ! Y LIU W CARTES D A | 2010 | IEEE Transactions on Industry Applications2010，46，3： | 1 |
| 7 | New clinical-practice guidelines for the management of pain in patients with cancer 显示文摘 | Jacox A Cart DB Payne R | 1994 | N Engl J Med1994，330，9： | 1 |
| 8 | A report on the first remote handling operations at JET 显示文摘 | Rolfe A C Brown P Carte P | 1999 | Fusion Engineering and Design1999，46，24： | 1 |
| 9 | Adverse effects of antiretroviral therapy显示文摘 | Cart A Cooper DA | 2000 | Lancet2000，356，9239： | 1 |
| 10 | Synchronisation based adaptive parameter identification for permanent magnet synchronous motors显示文摘 | Liu L Cartes D A | 2007 | IET Control Theory & Application2007，1，4： | 1 |
| 11 | Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire ( LCQ ) 显示文摘 | Birring SS Prudon B Cart A J | 2003 | Thorax2003，，58： | 1 |
| 12 | Lightning in relation to precipitation显示文摘 | Carte A E Kidder R E | 1977 | J Atmos Terr Phys1977，39，2： | 1 |
| 13 | 显示文摘 | DeMange P Negres R A Cart C W | 2005 | Proc of SPIE2005，5647，： | 1 |
| 14 | The role of Lewis acid-base processes in ligand-exchange chromatography of benzoic acid derivatives on zirconium oxide显示文摘 | John A Blackwell Peter W Cart | 1992 | Anal Chem1992，64，： | 1 |
| 15 | Review and simulation of homoplasy and collision in AFLP显示文摘 | CART G EEUWIJK F A V | 2012 | Euphytica2012，183，3： | 1 |
| 16 | Ultrasono- graphic quantitative estimation of hepatic steatosis in children with NAFLD显示文摘 | Shann on A Alkhouri N Carte r-Kent C | 2011 | J Pediatr Gastroenterol Nutr2011，53，2： | 1 |
| 17 | Preoperative evalu- ation of the entire hepatic vasculature in living liver donors with use of contrast-enhanced MR angiography and true fast imaging with steady-state precession 显示文摘 | Cart J Nemcek A Abeecassis M | 2003 | J Vasc Interv Ra- dial2003，14，4： | 1 |
| 18 | Selenium improves the antioxidant ability against aluminium-induced oxidative stress in ryegrass roots 显示文摘 | Cartes P Jara A Pinilla L | 2010 | Annals of Applied Biology2010，156，2： | 1 |
| 19 | Group music therapy for patients with persistent post-traumatic stress disorder--an exploratory randomized controlled trial with mixed methods evhluation显示文摘 | Cart C Ardenne P Sloboda A | 2012 | Psychol Psyehother2012，85，2： | 1 |
| 20 | Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury显示文摘 | Bose A K Mocanu M M Cart R D | 2005 | Diabetes2005，54，1： | 1 |
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