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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Cardiometabolic health among gastric bypass surgery patients with polycystic ovarian syndrome显示文摘AIM:To examine the effect of gastric bypass surgery on cardiometabolic health among women with polycystic ovarian syndrome(PCOS).METHODS:Retrospective medical chart review identified women(n = 389) with PCOS who underwent Roux-en-Y gastric bypass surgery from 2001-2009 in one surgical practice.Separate repeated measures linear mixed models were fit using the MIXED procedureto assess mean change in cardiometabolic disease risk factors from before to 1-year after surgery and were evaluated by ethnicity [Hispanic,non-Hispanic black(NHB) and white(NHW)].RESULTS:The majority of the sample was Hispanic(66%,25% NHB,9% NHW).Mean body mass index significantly improved 1 year post-surgery for all ethnic groups(45.5 to 35.5 kg/m2 for Hispanics,46.8 to 37.7 kg/m2 for NHB and 45.7 to 36.7 kg/m2 for NHW,P < 0.001).Among Hispanic women mean total cholesterol(198.1 to 160.2 mg/dL),low-density lipoproteins(LDL) cholesterol(120.9 to 91.0 mg/dL),triglycerides(148.6 to 104.8 mg/dL),hemoglobin A1c(6.2% to 5.6%),alanine aminotransferase(28.1 to 23.0 U/L) and aspartate aminotransferase(23.5 to 21.6 U/L) decreased significantly(P < 0.001).Among NHB,mean total cholesterol(184.5 to 154.7 mg/dL),LDL cholesterol(111.7 to 88.9 mg/dL) and triglycerides(99.7 to 70.0 mg/dL) decreased significantly(P < 0.05).Among NHW,mean total cholesterol(200.9 to 172.8 mg/dL) and LDL cholesterol(124.2 to 96.6 mg/dL),decreased significantly(P < 0.05).Pairwise ethnic group comparisons of all cardiometabolic outcomes adjusted for age and type of surgery before and 1 year after surgery showed no statistical difference between the three groups for any outcome.CONCLUSION:Cardiometabolic disease risk improvements vary by ethnicity and obesity may impact glucose tolerance and liver function changes more in Hispanic women with PCOS vs non-Hispanic women. | Carley A Gomez-Meade Adriana Carrillo Gabriela Lopez-Mitnik Sarah E Messiah Kristopher L Arheart Nestor de la Cruz-Muoz | 2013 | World Journal of Diabetes2013，4，3： | 6 |
| 3 | Immunoge-nicity of the P-8 amastigote antigen in the experimental model of canine visceral leishmaniasis显示文摘 | Carrillo E Ahmed S Goldsmith-Pestana K | 2007 | Vaccine2007，25，8： | 1 |
| 4 | Robust samplingand reconstruction methods for sparse signals in the pres-ence of impulsive noise 显示文摘 | Carrillo R E Earner K E Aysal T C | 2010 | IEEE Transactions on Select-ed Topics in Signal Processing2010，4，2： | 1 |
| 5 | Power fluctuations in an isolated wind plant显示文摘 | CARRILLO C FEIJOO A E CIDRAS J | 2004 | IEEE Transactions on Energy Conversion2004，19，1： | 1 |
| 6 | Peripheral inflammatory and fibrinolytic markers in adolescents with growth hormone deficiency:Relation to postprandial dyslipidemia显示文摘 | Lanes R Paoli M Carrillo E | | 0，，05： | 1 |
| 7 | A large scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of scape mutants显示文摘 | Taboga O Taml C Carrillo E | 1997 | Journal of Virology1997，71，4： | 1 |
| 8 | A large-scale evalution of peptide vaccines against Foot-and-Mouth disease: Lack of solid protection in cattle and isolation of escape mutants显示文摘 | Taboga O Tami C Carrillo E | 1997 | Journal of virology1997，71，4： | 1 |
| 9 | Genome - wide expression analyses of Campylobacterjejuni NCTC11168 reveals coordinate regulation of motility and virulence by flhA 显示文摘 | Carrillo CD Taboada E Nash JH | 2004 | Biol Chem2004，279，20： | 1 |
| 10 | Combining stereo vision and inertial navigation system for a quad-rotor uav显示文摘 | Garcia Carrillo L R Dzul Lopez A E Lozano R | 2012 | Journal of Intelligent & Robotic Systems2012，65，14： | 1 |
| 11 | Is subdiaphragmatic aortic cross-clamping a suitable model for spinal cord ischemia/reperfusion injury study in rats? 显示文摘 | Carrillo S E Guimaraes S B Vasconcelos P R | 2006 | Acta Cir Bras2006，21，4： | 1 |
| 12 | Potential for bio-logical control of Monilinia laxain peach twigs显示文摘 | Melgarejo P Carrillo R Sagasta E | 1986 | Crop Protection1986，5，6： | 1 |
| 13 | Fusion product planning: A market offering perspeetive显示文摘 | Chen Y Carrillo J E Vakharia A J | 2010 | Decision Sciences2010，41，2： | 1 |
| 14 | Real-time system for high-imagc resolution disparity estimation显示文摘 | DIAZ J ROS E CARRILLO R PRIETO A | 2007 | IEEE Transaction on hnage Processing2007，16，1： | 1 |
| 15 | Peripheral inflammatory and fibrinolytic markers in adolescents with growth hormone deficiency:Relation to postprandial dyslipidemia显示文摘 | Lanes R Paoli M Carrillo E | 2004 | J Pediatr2004，145，5： | 1 |
| 16 | Early elevation of soluble CD14 may help identify trauma patients at high risk for infection显示文摘 | Gordon L Carrillo EH Davis E | 2001 | J Trauma2001，50，2： | 1 |
| 17 | Mycoflora of peachtwigs and flowers and its possible significance in biologi-cal control of Monilinia laxa显示文摘 | Melgarejo P Carrillo R Sagasta E | 1985 | Transactions of theBritish Mycological Society1985，85，2： | 1 |
| 18 | Single versus multiple supplier sourcing strategies 显示文摘 | Burke G J Carrillo J E Vakharia A J | 2007 | European Journal of Operational Research2007，182，1： | 1 |
| 19 | Enhancement of red wine colour by prefermentation addition of copigment显示文摘 | Darias-Martin J Carrillo M Diaz E Boulton R B | 2001 | Food Chemistry2001，73，： | 1 |
| 20 | Comparative genomics of foot-and-mouth disease显示文摘 | CARRILLO C TULMAN E DELHON G | 2005 | Virus2005，79，10： | 1 |
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