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| 1 | Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review显示文摘BACKGROUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies.Different signaling pathways that participate in the progression of these tumors have been identified.B-raf proto-oncogene serine/threonine kinase(BRAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell mechanisms.BRAF gene mutations have been identified in ameloblastomas,of which the BRAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior.Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.AIM To document the presence of BRAF V600E and additional mutations,their behavior,and targeted therapies in these tumors.METHODS An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE,Cochrane,EMBASE,and SpringerLink using the terms“ameloblastomas”,“BRAF V600E”,“additional mutations”,and“targeted therapies”.Ameloblastomas were classified according to WHO guidelines.Inclusion criteria were articles in English,published not more than 10 years ago,and studies with laboratory works related to BRAF V600E.Articles were evaluated by two independent reviewers and retrieved for full-text evaluation.The EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible studies.Descriptive statistical analysis was performed.RESULTS Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this study.The analysis registered 521 conventional ameloblastomas(AM),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(MA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatomic location,laboratory tests,expression of BRAF mutation,and additional mutations were registered.The BRAF V600E mutation was found in 297 AM(57%),63 UA(77.7%),3 AC(23%),1 MA(50%),and 5 PA(83.3%).Follicular type predominated with a total of 116 cases(40%),followed by plexiform type with 63 cases(22.1%).Furthermore,both types presented additional mutations,in which alterations in JAK3 P132T,SMARCB1,PIK3CA,CTNNB1,SMO,and BRAF G606E genes were found.Four case reports were found with targeted therapy to BRAF V600E.CONCLUSION The identification of BRAF V600E and additional mutations as an aid in targeted therapies has been a breakthrough in alternative treatments of ameloblastomas where surgical treatments are contraindicated. | Rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina | 2020 | World Journal of Clinical Oncology2020，11，1： | 6 |
| 2 | Is nasogastric or na- sojejunal decompression necessary after gastrectomy? A prospective randomized trial显示文摘 | Carr~re N Seulin P Julio CH | 2007 | World J Surg2007，31，1： | 1 |
| 3 | The behavior of bearings used for seismic isolation under shear and axial load 显示文摘 | P J Moss N Cook A J Carr | 1999 | Earthquake Spectra1999，15，2： | 1 |
| 4 | Semivariogram textural classification of JERS-1(FUYO-1) SAR data obtained over a flooded area of the Amazonian rainforest显示文摘 | Miranda F P Fonseca L E N Carr J R | 2000 | International Journal of Remote Sensing2000，19，3： | 1 |
| 5 | Dipeptidyl peptidase- 1V inhibitor use associated with increased risk of ACE inhibitor-associated angioedema 显示文摘 | Brown N J Byiers S Carr D | 2009 | Hypertension2009，54，3： | 1 |
| 6 | Pioglitazone increases the fractional catabolic and production rates of high-density lipoproteins apo AI in the New Zealand White Rabbit显示文摘 | Carreón-Torres E Juárez-Meavepe(n)a M Cardoso-Salda(n)a G | 2005 | Atherosclerosis2005，181，2： | 1 |
| 7 | Predictive value of viral load and other markers for progression to clinical AIDS after CD4+ cell count falls below 200/micro L显示文摘 | Carre N Boufassa F Hubert JB | 1998 | Int J Epidemion1998，27，5： | 1 |
| 8 | Design Method for Bridges on Lead-rubber Bearings显示文摘 | Turkington D H Carr A J Cooke N Moss P J | 1989 | Journal of Structural Engineering1989，115，12： | 1 |
| 9 | Dissociative Chemisorption of CH4 on Ni: The role of molecular orientation显示文摘 | Jackson B | 1998 | J Chem Phys1998，108，9： | 1 |
| 10 | Viscosity of hydrocarbon gases under pressure显示文摘 | Carr N L Kobayashi R Burrows D B | 1954 | Journal of Petroleum Technology1954，6，10： | 1 |
| 11 | Effectiveness of ractopamine hydrochloride on growth performance, carcass composition and sensory characteristics in heavy weight finishing swine 显示文摘 | Herr C T Autrey B A Carr S N | 2007 | Journal of Animal Science2007，，85： | 1 |
| 12 | Effectiveness of ractopam in ehydroch loride on growth performance, carcass composition and sensory characteristics in heavy weight finishing swine显示文摘 | HERR C T A~Y B A CARR S N | 2007 | Journal of Animal Science2007，87，： | 1 |
| 13 | Lifestyle Factors, Obesity and the Risk of Chronic Kidney Disease显示文摘 | Bénédicte Stengel Michelle E. Tarver–Carr Neil R. Powe Mark S. Eberhardt Frederick L. Brancati | 2003 | Epidemiology2003，，4： | 1 |
| 14 | Creatine monohydrate supplementation and the quality of fresh pork in normal and halothane carrier pigs显示文摘 | Maddock R J Bidner B S Carr S N | 2002 | Journal of Animal Science2002，80，： | 1 |
| 15 | Mass Transfer Coefficients and Solubilities for Hydrogen and Carbon Monoxide Under Fishcer-Tropsch Conditions显示文摘 | Albal R S Shah Y T Carr N L | 1984 | Chem Eng Sci1984，39，5： | 1 |
| 16 | Creatine monohydrate supplementation and the quality of fresh pork in normal and halothane carrier pigs显示文摘 | Maddock R J Bidner B S Carr S N | 2002 | Journal Animal Science2002，80，： | 1 |
| 17 | An Exploratory Study of Gendered Differences in Young Tourists Perception of Danger within London 显示文摘 | Carr N | 2001 | Tourism Management2001，22，5： | 1 |
| 18 | Protein biomarker discovery and validation:the long and uncertain path to clinical utility显示文摘 | Rifai N Gillette M A Carr S A | | 0，，： | 1 |
| 19 | Strategically managed buyer-supplier relation- ships and performance outcome显示文摘 | Carr A S Pearson J N | 1999 | Journal of Operations Management1999，，17： | 1 |
| 20 | The lactic acid bacteria: A literature survey显示文摘 | Carr FJ Chill D Maida N | 2002 | Crit Rev Microbiol2002，28，4： | 1 |
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