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1篇 您的检索式：作者名="Carlo Mattozzi"

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		题名	作者	年代	出处	被引量
	1	Safety and efficacy of anti-tumor necrosis factors α in patients with psoriasis and chronic hepatitis C显示文摘Up to date,in literature,it is still debated the role of anti-tumor necrosis factors(TNF)-α treatments in hepatitis C virus(HCV) patients.TNF-α performs a lot of functions,it is an important pro-inflammatory cytokine and it is involved in the host's immunity.Since TNF-α is implicated in the apoptotic signaling pathway of hepatocytes infected by HCV,anti TNF-α therapy may increase the risk of viral replication or their reactivation.However the treatment of anti TNF-α could have a healthful role because TNF-α appears to be engaged in the pathogenesis of liver fibrosis,inducing apoptotic pathways.We describe the case of a patient with plaquetype psoriasis and concomitant chronic HCV,who was treated successfully with anti-TNF agents simultaneously to cyclosporine without sign of reactivation of HCV and increase of liver enzymes.Our personal experience shows that anti-TNF-α agents are not only effective but also safe.Furthermore the combination therapy of cyclosporine and anti-TNF-α appears to be well-tolerated and able to reduce the amount of liver enzymes as well as HCV-viral-load.However systematic,large-scale studies with long follow-ups will be needed to confirm our results,in association with close liver function monitoring.	Monica Salvi Laura Macaluso Cecilia Luci Carlo Mattozzi Giovanni Paolino Yvonne Aprea Stefano Calvieri Antonio Giovanni Richetta	2016	World Journal of Clinical Cases2016，4，2：	1

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