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| 1 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 2 | Management of autoimmune hepatitis:Focus on pharmacologic treatments beyond corticosteroids显示文摘In autoimmune hepatitis, patients who are intolerant or with toxicity experience, non-responders, relapsers or refractory are challenging. Non-standard drugs are being tried to preemptively avoid corticosteroid-related side effects. Prognosis and quality of life of life rely on treatment optimization. Recently, emergence of powerful immunosuppressive agents, mainly from liver transplantation, challenged the supremacy of the corticosteroid regime and promise greater immunosuppression than conventional medications, offer site-specific actions and satisfactory patient tolerance. Successes in experimental models of related diseases have primed these molecular interventions. We performed a literature review on alternative treatments. Azatioprine intolerance is the principal indication for mycophenolate use butit can be used as a front-line therapy. Cyclosporine A and tacrolimus have been tested for non-responders or relapsers. Rituximab may be used as salvage therapy. Anti-tumor necrosis factor-alpha agents may be used for incomplete responses or non-responders. Methotrexate is possibly an alternative for induction of remission and maintenance in refractory patients. Cyclophosphamide has been included in the induction regimen with corticosteroids. Ursodeoxycholic acid action is mainly immunomodulatory. Non-standard treatments are coming slowly to the attention, but its use should be cautious performed by experienced centers. | Marta Casal Moura Rodrigo Liberal Hélder Cardoso Ana Maria Horta e Vale Guilherme Macedo | 2014 | World Journal of Hepatology2014，6，6： | 2 |
| 3 | Recherches experimentales sur quelques proprietes thermiques des gaz-elements critiques et tensions de vapeur de l'oxyde de methyle 显示文摘 | Cardoso E Bruno A | 1923 | J Chim Phys1923，20，1： | 2 |
| 4 | A blind source separation technique based on second order statistics显示文摘 | A Belouchrani K A Merairn J-F Cardoso E Moulines | 1997 | reEF transactions on Signal Processing1997，45，2： | 1 |
| 5 | Posttraumatic hydrocephalus:a respective review显示文摘 | Cardoso E R Galbraith S | 1985 | Surg Neurol1985，23，： | 1 |
| 6 | Non-in- flammatory destructive periodontal disease : a clinical, mi- crobiological, immunological and genetic investigation 显示文摘 | Repeke C E Cardoso C R Claudino M | 2012 | Journal of Application Oral Science2012，20，1： | 1 |
| 7 | In situ FT-IR and ex situ EPR analysis for the study of the electroreduction of carbon dioxide in N, N-dimethylformamide on a gold interface显示文摘 | P6rez E R Garcia J R Cardoso D R | 2005 | J Electroanal Chem2005，578，1： | 1 |
| 8 | Subspace methods for the blind identification of multi-channel FIR filters 显示文摘 | Moulines E Duhamel P Cardoso J | 1995 | IEEE Transactions on Signal Processing1995，43，2： | 1 |
| 9 | Reliable eighteenhour lung preservation at 4 degrees and 10 degrees by pulmonary artery flush after high-dose prostaglandin E1 administration显示文摘 | Mayer E Puskas J D Cardoso P F | 1992 | J Thorac Cardiovasc Surg1992，103，： | 1 |
| 10 | A review of the treatment of endocrine responsive metastatic breast cancer in postmenopausal women 显示文摘 | Cardoso F Bischoff J Brain E | 2013 | Cancer Treat Rev2013，39，5： | 1 |
| 11 | Organo functionalized kenyaite for dye removal from aqueons solution 显示文摘 | Royer B Cardoso N F Lima E C | 2009 | J Colloid Interface Sci2009，336，2： | 1 |
| 12 | Subspace methods for the blind identification of multichannel FIR filters显示文摘 | Moulines E Duhannel P Cardoso J F | 1995 | IEEE Trans on Signal Processing1995，43，2： | 1 |
| 13 | The use of amniotic membrane in the repair of duodenal wounds in Wistar rats显示文摘 | Schimidt L R Cardoso E J Schimidt R R | 2010 | Acta Cir Bras2010，25，1： | 1 |
| 14 | Biomechanical contribution of transverse connectors to segmental stability following long segment instrumentation with thoracic pedicle screw 显示文摘 | Kuklo T R Dmitreiv A E Cardoso M J | 2008 | Spine2008，33，15： | 1 |
| 15 | Thoracic myelopathy secondary to ossified ligamentum flavum显示文摘 | Omojola M F Cardoso E R Fox A J | 1982 | J Neurosurg1982，56，3： | 1 |
| 16 | Niemann-Pick disease type C:a case series of Brazilian patients显示文摘 | Lorenzoni PJ Cardoso E Crippa AC | 2014 | Arq Neuropsiquiatr2014，72，3： | 1 |
| 17 | Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum 显示文摘 | Duarte M E R Cardoso Marc Noseda M D | 2001 | Carbohydr Res2001，333，： | 1 |
| 18 | Brava and autologous fat transfer Is a safe and effective breast augmentation alternative: re?sults of a 6-year, 81-patient, prospective multicenter study显示文摘 | Khouri RK1 Eisenmann - Klein M Cardoso E | 2012 | Plast Reconslr Surg2012，129，5： | 1 |
| 19 | Megavolume autologous fat transfer: Part n : Practice and techniques显示文摘 | Khouri RK Rigotti G Cardoso E et a1 | 2014 | Plast Reconstr Surg2014，133，6： | 1 |
| 20 | Friedel-Crafts acylaiton of anisole with acetic anhydride over silica-supported hetempolyphostungstic acid (HPW/SiO2 )显示文摘 | CARDOSO L A M ALVES W It GONZAGA A R E AGUIAR L M G ANDRADE H M C | 2004 | J Mol Catal A2004，209，12： | 1 |
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