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13篇 您的检索式：作者名="Cardone J D"

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		题名	作者	年代	出处	被引量
	1	Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival显示文摘AIM: To investigate the function of NOD2 in colonic epithelial cells (CEC). METHODS: A combination of in vivo and in vitro analyses of epithelial cell turnover in the presence and absence of a functional NOD2 protein and, in response to enteric Salmonella typhimurium infection, were used. shRNA interference was also used to investigate the consequences of knocking down NOD2 gene expression on the growth and survival of colorectal carcinoma cell lines. RESULTS:In the colonic mucosa the highest levels of NOD2 expression were in proliferating crypt epithelial cells. Muramyl dipeptide (MDP), that is recognized by NOD2, promoted CEC growth in vitro . By contrast,the growth of NOD2-deficient CECs was impaired. In vivo CEC proliferation was also reduced and apoptosis increased in Nod2-/- mice, which were also evident following enteric Salmonella infection. Furthermore, neutralization of NOD2 mRNA expression in human colonic carcinoma cells by shRNA interference resulted in decreased survival due to increased levels of apoptosis. CONCLUSION: These findings are consistent with the involvement of NOD2 protein in promoting CEC growth and survival. Defects in proliferation by CECs in cases of CD may contribute to the underlying pathology of disrupted intestinal homeostasis and excessive inflammation.	Sheena M Cruickshank Louise Wakenshaw John Cardone Peter D Howdle Peter J Murray Simon R Carding	2008	World Journal of Gastroenterology2008，14，38：	3
	2	Gene frequenciesof the HPA-15(Gov)platelet alloantigen system in Brazilians显示文摘	Cardone J D Chiba A K Boturo-Neto E	2004	Transfus Med2004，14，6：	1
	3	Topical capsaiein for treatment of hemodialysis -related pruritus显示文摘	BRENEMAN D L CARDONE J S BLUMSACKLTLR F	1992	Am Acad Dermatol1992，26，：	1
	4	Topical capsaicin for treatment of hemodialysis-related pruritus 显示文摘	Breneman D L Cardone J S Blumsack R F	1992	J Am Acad Dermatol1992，26，1：	1
	5	Determining root activity distribution by measuring surface carbon dio xide uses显示文摘	BERR ASHER J CARDON G E RETERS D	1994	Soil Sci Soc Am J1994，88，：	1
	6	Human neutrophil alloantigens systems 显示文摘	MORITZ E NORCIA A M CARDONE J D	2009	An Acad Bras Cienc2009，81，：	1
	7	Transient Photoconductivity Study of Shallow Elecutron Traps in ^4- Doped AgCl Microcrystals: Effects of Doping Concentration and Position显示文摘	Hha J P Callen F Cardon F Vandenbrouche D	1999	J Imag Sci Tech1999，47，：	1
	8	Associations of neighborhood characteristics with active park use:an observational study in two cities in the USA and Belgium显示文摘	Van Dyck D Sallis J F Cardon G	2013	Int J Health Geogr2013，12，：	1
	9	A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity 显示文摘	Frayling TM Timpson N J Weedon MN Zeggini E Freathy RM Lindgren CM Perry JR Elliott KS Lango H Rayner NW Shields B Harries LW Barrett JC Ellard S Groves C J Knight B Patch AM Ness AR Ebrahim S Lawlor DA Ring SM Ben-Shlomo Y Jarvelin MR Sovio U Bennett A J Melzer D Ferrucci L Loos RJ Barroso I Wareham N J Karpe F Owen KR Cardon LR Walker M Hitman GA Palmer CN Doney AS Morris AD Smith GD Hattersley AT McCarthy MI 2007	2007	Science2007，316，：	1
	10	Determining root activity distribution by measuring surface carbon dioxide fluxes显示文摘	Ben-Asher J Cardon G E Peters D	1994	Soil Science Society of America Journal1994，，58：	1
	11	T-spline simplification and local refinement 显示文摘	Sederberg T W Cardon D L Zheng J M	2004	ACM Transactions on Graphics2004，23，3：	1
	12	Gene frequencies of the HNA-4a and-5a neutrophil antigens in Brazilian persons and a new polymerase chain reaction-restriction fragment length polymorphism method for HN A -5 a genotyping 显示文摘	Cardone J D Bordin J 0 Chiba A K	2006	Transfusion2006，46，9：	1
	13	Valuation of contemporary ocean wave models in rare extreme events:the 'Halloween Storm'of October,1991 and the 'Storm of the Century' of March,1993显示文摘	CARDONE V J JENSEN R E RESIO D T	1996	Atmos Oceanic Tech1996，13，：	1

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