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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Epidemiology of extended-spectrum beta-lactamase-producing Enterobacter isolates in a Spanish hospital during a 12-year period 显示文摘 | Canton R Oliver A Coque T M | 2002 | J Clin Microbiol2002，40，： | 3 |
| 3 | Clinical applications of growth factors in bone injuries:experience with BMPs显示文摘 | Ronga M Fagetti A Canton G | 2013 | Injury2013，44，1： | 1 |
| 4 | A re-evaluation of the biokinetics of zirconium in bumans 显示文摘 | Veronese I Giussani A Cantone M C | 2003 | Applied Radiation and Isotopes2003，58，： | 1 |
| 5 | A review of transcranial magnetic stimulation in vascular dementia显示文摘 | Pennisi G Ferri R Cantone M | 2011 | Dement Geriatr Cogn Disord2011，31，1： | 1 |
| 6 | A technique for the determination of ruthenium stable isotopes in urine samples 显示文摘 | Veronese I Cantone M C Giussani A | 2007 | Journal of Radioanalytical and Nuclear Chemistry2007，271，2： | 1 |
| 7 | The nature of uncoupling by n-hexane,1-hexanethiol and 1-hexanol in rat liver mitochondria显示文摘 | Canton M Gennari F | 1996 | Biochemistry et Biophysics1996，1274，： | 1 |
| 8 | Thermal comfort in forested urban canyons of low building density: an assessment for the city of Mendoza, Argentina 显示文摘 | CORREA E RUIZ M A CANTON A | 2012 | Building and Environment2012，58，： | 1 |
| 9 | Nucleation and crystallization behavior of glass-ceramic materials in the Li2O-Al2O3-SiO2 system of interest for their transparency properties显示文摘 | RIELLO P CANTON P COMELATO N POLIZZI S VERITA M FAGHERAZZI G~ HOFMEISTER H HOPFE S | 2001 | Journal of Non-Crystalline Solids2001，2280，： | 1 |
| 10 | Clinical applications of growth factors in bone injuries: experience with BMPs 显示文摘 | Ronga M Fagetti A Canton G | 2013 | Injury2013，44，1： | 1 |
| 11 | Factors affecting clinical outcome following endoscopic perforator vein ablation显示文摘 | Gloviczki P Canton L G | 1998 | Am J Surg1998，176，2： | 1 |
| 12 | Variations in the prevalence of strains expressing an extended-spectrum beta-lactamase phenotype and characterization of isolates from Europe, the American, and the Western Pacif ic region显示文摘 | Winkur P L Canton R Casellas J M | 2001 | Clin Infect Dis2001，32，2： | 1 |
| 13 | Mitochondria and cardioprotection 显示文摘 | di Lisa F Canton M Menabb R | 2007 | Heart Fail Rev2007，12，： | 1 |
| 14 | Reproducibility of short term and reproduction toxicity experiments with Daphnia magna and comparison of the sensitivity of Daphnia magna with Daphnia pulex and Daphnia cucculata in shortterm expe riments显示文摘 | Canton J H Adema D M | 1978 | Hydrobiologia1978，59，： | 1 |
| 15 | A review of transcranial magnetic stimulation in vascular dementia显示文摘 | Pennisi G Ferri R Cantone M | 2011 | Dement Gerialr Cogn Disord2011，31，1： | 1 |
| 16 | CTX-M:changing the face of ESBLs in Europe显示文摘 | David M Livermore Rafael Canton | 2007 | J Antimicrob Chemother2007，59，3： | 1 |
| 17 | Mitochondia and reperfusionin jury-the role of permeability transition显示文摘 | Di Lisa F Canton M Menaba R | 2003 | Basic Res Cardiol2003，98，4： | 1 |
| 18 | Dialysis practice and patientoutcome in the aftermath of the earthquake at L‘Aquila, Italy, April2009显示文摘 | Bonomini M Stuard S Dal Canton A | 2011 | Nephrol Dial Transplant2011，26，8： | 1 |
| 19 | Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD^+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart显示文摘 | DILISA F MENABO R CANTON M | 2001 | J Biol Chem2001，276，4： | 1 |
| 20 | A tech- nique for the determination of ruthenium stable iso- topes in urine samples显示文摘 | Veronese I Cantone M C Giussani A | 2007 | Journal of Radioanalytical and Nuclear Chemistry2007，271，2： | 1 |
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