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| 1 | Role of pro-and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity显示文摘In obesity, persistent low-grade inflammation is considered as a major contributor towards the progression to insulin resistance and type 2 diabetes while in lean subjects the immune environment is non-inflammatory. Massive adipose tissue(AT) infiltration by pro-inflammatory M1 macrophages and several T cell subsets as obesity develops leads to the accumulation-both in the AT and systemically-of numerous pro-inflammatory cytokines, including interleukin-1β(IL-1β), tumor necrosis factor a, IL-17 and IL-6 which are strongly associated with the progression of the obese phenotype towards the metabolic syndrome. At the same time, anti-inflammatory M2 macrophages and Th subsets producing the antiinflammatory cytokines IL-10, IL-5 and interferon-γ, including Th2 and T-reg cells are correlated to the maintenance of AT homeostasis in lean individuals. Here, we discuss the basic principles in the control of the interaction between the AT and infiltrating immune cells both in the lean and the obese condition with a special emphasis on the contribution of pro-and antiinflammatory cytokines to the establishment of the insulinresistant state. In this context, we will discuss the current knowledge about alterations in the levels on pro-and antiinflammatory cytokines in obesity, insulin resistance and type 2 diabetes mellitus, in humans and animal models. Finally, we also briefly survey the recent novel therapeutic strategies that attempt to alleviate or reverse insulin resistance and type 2 diabetes via the administration of recombinant inhibitory antibodies directed towards some pro-inflammatory cytokines. | Luciano Pirola JoséCandido Ferraz | 2017 | World Journal of Biological Chemistry2017，8，2： | 10 |
| 2 | Efficacy and safety of stellate ganglion block in chronic ulcerative colitis显示文摘Sympathetic system modulation by stellate ganglion blockade may modulate immune dysfunction and significantly improve symptoms of chronic ulcerative colitis. | Eugene Lipov Ken Candido | 2017 | World Journal of Gastroenterology2017，23，17： | 6 |
| 3 | 互联网金融产品风险管理问题研究--以余额宝为例显示文摘随着我国经济和信息技术的进步,互联网金融行业也蓬勃发展起来,与此同时,互联网金融行业的风险管理也是备受关注的一个问题。互联网金融行业是否安全可靠对互联网金融行业的未来发展前景有着直接的影响,而互联网金融产品风险又是金融风险防范中不可或缺的一部分,随着该行业的迅速发展,互联网金融面临着诸多风险和挑战。 | 陈博 Candido M.Perez 彭方 | 2022 | 中国市场2022，，3： | 4 |
| 4 | Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance(Review)显示文摘 | Sameh Hafsi Franca Pezzino Saverio Candido Giovanni Ligresti Demetrios Spandidos Zohra Soua James McCubrey Salvatore Travali Massimo Libra | 2012 | International Journal of Oncology2012，，3： | 4 |
| 5 | The tumor microenvironment in hepatocellular carcinoma (Review)显示文摘 | Giulia Leonardi Saverio Candido Melchiorre Cervello Daria Nicolosi Fabio Raiti Salvatore Travali Demetrios Spandidos Massimo Libra | 2012 | International Journal of Oncology2012，，6： | 3 |
| 6 | Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation:A minireview显示文摘Mesenchymal stromal cells(MSCs) possess great therapeutic advantages due to their ability to produce a diverse array of trophic/growth factors related to cytoprotection and immunoregulation.MSC activation via specific receptors is a crucial event for these cells to exert their immunosuppressive response.The aryl-hydrocarbon receptor(Ah R) is a sensitive molecule for external signals and it is expressed in MSCs and,upon positive activation,may potentially regulate the MSC-associated immunomodulatory function.Consequently,signalling pathways linked to Ah R activation can elucidate some of the molecular cascades involved in MSC-mediated immunosuppression.In this minireview,we have noted some important findings concerning MSC regulation via Ah R,highlighting that its activation is associated with improvement in migration and immunoregulation,as well as an increase in pro-regenerative potential.Thus,Ah R-mediated MSC activation can contribute to new perspectives on MSC-based therapies,particularly those directed at immune-associated disorders. | Danilo Candido de Almeida Laura Sibele Martins Evangelista Niels Olsen Saraiva Camara | 2017 | World Journal of Stem Cells2017，9，9： | 2 |
| 7 | Transgenic Caenorhabditis elegans strains as biosensors显示文摘 | Candido E P Jones D | 1996 | Trends in Biochemistry1996，14，： | 2 |
| 8 | Cancer-Related Inflammation显示文摘 | Juliana Candido Thorsten Hagemann | 2013 | Journal of Clinical Immunology2013，，1： | 2 |
| 9 | Cesarean section as a cause of chronic pelvic pain显示文摘 | Almeida EC Nogueira AA Candido dos Reis FJ | 2002 | Int J Gynaecol Obstet2002，79，： | 1 |
| 10 | Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat 显示文摘 | Tikellis C Wookey PJ Candido R | 2004 | Diabetes2004，53，4： | 1 |
| 11 | Stress protein expression in coho salmon with bacterial kidney disease显示文摘 | FORSYTH R B CANDIDO P M | 1997 | Aquatic Animal Health1997，9，： | 1 |
| 12 | In vitro activity of antimycotic agents determined by E-test met Candidia species 显示文摘 | Tolod MR Franceschin SA | 1998 | Mycopathologia1998，144，1： | 1 |
| 13 | Cormective tissue growth factor and cardiac fibrosis after myocardial infarction 显示文摘 | Balding LC Candido R | 2005 | Histochem Cytochem2005，53，10： | 1 |
| 14 | Experimental evaluation of the structural response of perfobond shear connectors显示文摘 | CANDIDO M COSTA N PCGDAS V | 2010 | Engineering Structures2010，32，： | 1 |
| 15 | Transgenic Caenorhabditis elegans strains as biosensors 显示文摘 | Candido E P Jones D | 1996 | Trends in Biochemistry1996，14，： | 1 |
| 16 | Improved islet morphology after blockade of the rennin-angiotensin system in the ZDF rat显示文摘 | Tikellis C Wookey PJ Candido R | 2004 | Diabetes2004，53，4： | 1 |
| 17 | A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes显示文摘 | Candido R Forbes JM Thomas MC | 2003 | Circ Res2003，92，4： | 1 |
| 18 | Use of a levonorgestrel-releasing intrauterine device for the symptomatic treatment of uterine myomas显示文摘 | Rosa e Silva JC Rosa e Silva AC de Sa Candido dos Reis FJ | 2005 | J Reprod Med2005，50，8： | 1 |
| 19 | Connective tissue growth fac- tor and cardiac fibrosis after myocardial infarction 显示文摘 | Dean RG Balding LC Candido R | 2005 | J Histochem Cytoche2005，53，10： | 1 |
| 20 | Improved Islet Morphology after Blockade of the Renin - Angiotensin System in the ZDF Rat 显示文摘 | Tikellis C Wockey DJ Candido R | 2004 | Diabetes2004，53，： | 1 |
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