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| 1 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 2 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 3 | Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms显示文摘AIM To critically review the literature addressing the definition, epidemiology, aetiology and pathophysiology of acute colonic pseudo-obstruction(ACPO).METHODS A systematic search was performed to identify articles investigating the aetiology and pathophysiology of ACPO. A narrative synthesis of the evidence was undertaken. RESULTS No consistent approach to the definition or reporting of ACPO has been developed, which has led to overlapping investigation with other conditions. A vast array of risk factors has been identified, supporting a multifactorial aetiology. The pathophysiological mechanisms remain unclear, but are likely related to altered autonomic regulation of colonic motility, in the setting of other predisposing factors. CONCLUSION Future research should aim to establish a clear and consistent definition of ACPO, and elucidate the pathophysiological mechanisms leading to altered colonic function. An improved understanding of the aetiology of ACPO may facilitate the development of targeted strategies for its prevention and treatment. | Cameron I Wells Gregory O’Grady Ian P Bissett | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 4 | Exploration of die wall friction for powder compaction using a discrete finite element modelling technique显示文摘 | Gethin D T | 2001 | Modelling and Simulation in Materials Science and Engineering2001，9，： | 1 |
| 5 | Response and modeling of cantilever retaining walls subjected to seismic motions显示文摘 | GREEN R A OLGUN C G CAMERON W I | 2008 | Computer-Aided Civil and Infrastructure Engineering2008，23，4： | 1 |
| 6 | Finding deeply-buried deposits using geochemistry显示文摘 | Cameron E M Hamilton S M Leyboume M I | 2004 | Geochemistry: Exploration Environment Analysis2004，4，1： | 1 |
| 7 | Endothelial cell pseudopods and angiogenesis of breast cancer tumors显示文摘 | CAMERON I L SHORT N SUN L Z | 2005 | Cancer Cell Int2005，5，1： | 1 |
| 8 | Cyclical progestogens for heavy menstrul bleeding显示文摘 | Lethaby A lrvine G Cameron I | 2000 | Cochrane Database Syst Rev2000，，00： | 1 |
| 9 | The management of pancreatic trauma显示文摘 | Khan MA Cameron I | 2010 | J R Army Med Corps2010，156，4： | 1 |
| 10 | Exploring for deeply-covered mineral deposits : Formation of geochemical anomalies in Northern Chile by earthquake- induced surface flooding of mineralized groundwaters 显示文摘 | Cameron E M Leybourne M I Kelley D L | 2002 | Geology2002，30，11： | 1 |
| 11 | Long-term consequences offoetalrestriction显示文摘 | Godfrey K Cameron I Hanson M | 2006 | Gurrent Obsterics Gynaecol2006，16，5： | 1 |
| 12 | Understanding and predicting private motorized urban mobility 显示文摘 | Cameron I Kenworthy J R Lyons T J | 2003 | Transportation Research PartD2003，，8： | 1 |
| 13 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Hysiol2006，290，： | 1 |
| 14 | Mycorrhizal ac- quisition of inorganic phosphorus by the green-leaved ter- restrial orchid Goodyera repens 显示文摘 | Cameron D D Johnson I Leake J R | 2007 | Annals of Botany2007，99，： | 1 |
| 15 | Intensive care unit-acquired weakness: clinical phenotypes and molecu- lar mechanisms显示文摘 | Batt J Santos C C Cameron J I | 2013 | Am J Respir Crit Care Med2013，187，3： | 1 |
| 16 | Inorganic-N release from spent mushroom compost under laboratory and field conditions 显示文摘 | STEWART D P C CAMERON K C Cornforth I S | 1998 | Soil Biology and Biochemistry1998，30，13： | 1 |
| 17 | Evidence for the optimal management of acute and chronic phantom pain: A systematic review显示文摘 | HALBERT J CROTTY M CAMERON I D | 2002 | Clin J Pain2002，18，： | 1 |
| 18 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Physiol2006，290，： | 1 |
| 19 | Pravalence and characters of Barrett's esophagns in patients with adenocarcinoma of the esophagus or esophagugastric junction显示文摘 | Hamilton SR Smith RL Cameron J I | 1998 | Hum Pathol1998，19，： | 1 |
| 20 | Plant regeneration from leaf - derived callus culture of the tropical pasture legume Stylosanthes scabra Vog显示文摘 | Godwin I D Gordon G H Cameron D F | 1987 | Plant Cell Tissue Organ Cult1987，9，： | 1 |
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