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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | The fate of absorbed and exogenous ammonia as influenced by forage or forage- concentrate diets in growing sheep显示文摘 | Lobley G E Weijs P J M Connell A Calder A G Brown D S Milne E | 1996 | British Journal of Nutrition1996，76，： | 1 |
| 3 | Microstructure evolution in magnetorheological suspensions governed by Mason number显示文摘 | Melle S Calderón O G Rubio M A | 2003 | Phys Rev2003，68，04： | 1 |
| 4 | Influence of ethanol and heat on disease control and quality in stored mango fruits显示文摘 | Guti 6 rrez-Mart f nez P Osuna-L 6 pez S Calder 6 n- Santoyo M | 2012 | LWT-Food Science Technology2012，45，： | 1 |
| 5 | Peripheral abnormality in multiple sclerosis显示文摘 | Pollock M Calder C Allpress S | 1977 | Ann Neurol1977，2，1： | 1 |
| 6 | Thermal plasma synthesis of superparamagnetic iron oxide nanoparticles显示文摘 | Lei P Y Boles A M Calder S Girshick S L | 2012 | Plas- ma Chemistry and Plasma Processing2012，2，3： | 1 |
| 7 | A Principal Component Analysis of Facial Expressions显示文摘 | CALDER A J BURTON A M MILLER P YOUNG A W AKAMATSU S | 2001 | Vision Research2001，41，： | 1 |
| 8 | Peripheral nerve abnormality in multiple sclerosis显示文摘 | POLLOCK M CALDER C ALLPRESS S | 1977 | Ann Neurol1977，2，： | 1 |
| 9 | Thermal plasma synthesis of superparamagnetie iron oxide nanoparticles显示文摘 | Lei P Y Boies A M Calder S Girshick S L | 2012 | Plas- ma Chemistry and Plasma Processing2012，2，3： | 1 |
| 10 | Peripheral nerve abnormality in multiple sclerosis显示文摘 | Pollock M Calder C Allpress S | 1977 | Ann Neurol1977，2，： | 1 |
| 11 | T cells and fibroblasts in affected extraocular muscles in early and late thyroid associated ophthalmopathy显示文摘 | PAPPA A LAWSON J M CALDER V FELLS P LIGHTMAN S | 2000 | Br J Ophthalmol2000，84，： | 1 |
| 12 | A comparative study of the turbulent Rayleigh-Taylor instability using high-resolution three-dimensional numerical simulations: the Alpha-Group collaboration 显示文摘 | Dimonte G Youngs D L Dimits A Weber S Marinak M Wunsch S Garasi C Robinson A Andrews M J Ramaprabhu P Calder A C Fryxell B Biello J Dursi L MacNeice P Olson K Ricker P Rosner R Timmes F Tufo H Young Y N Zingale M | 2004 | Physics of Fluids2004，16，5： | 1 |
| 13 | Peripheral abnormality in mul-tiple sclerosis显示文摘 | Pollock M Calder C Allpress S | 1997 | Ann Neurol1997，2，： | 1 |
| 14 | Properties of the Michaelis-Menten mechanism in phase space显示文摘 | Calder M S Siegel D | 2008 | J Math Anal Appl2008，339，2： | 1 |
| 15 | Peripheralnerve abnonality in nultiple sclerosi显示文摘 | Poollock M Calder C Allpress S | 1997 | Ann Neurol1997，2，： | 1 |
| 16 | Thermal Plasma Syn- thesis of Superparamagnetic Iron Oxide Nanoparticles显示文摘 | Lei P Boies A M Calder S | 2012 | Plasma Chemistry and Plasma Processing2012，32，3： | 1 |
| 17 | Bif-1and Bax expression in cutaneous Merkel cell carcinoma显示文摘 | Schlauder S M Calder K B Khalil F K | 2009 | J Cutan Pathol2009，36，1： | 1 |
| 18 | Development and evaluation of sediment quality guidelines for Flor- ida coastal waters 显示文摘 | Donald D M Carr R S Calder F D | 1996 | Ecotoxicology1996，32，5： | 1 |
| 19 | Energy efficiency assessment by process heating assessment and survey tool (PHAST) and feasibility analysis of waste heat recovery in the reheat furnace at a steel company显示文摘 | Si M Thompson S Calder K | 2011 | Renewable and Sustainable Energy Reviews2011，15，6： | 1 |
| 20 | Acetylcholine re-ceptor expression in merkel cell carcinoma 显示文摘 | Bowers J W Schlauder S M Calder K B | 2008 | Am J Dermato-pathol2008，30，4： | 1 |
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