|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transmission electron mi- croscopy of air-processed Gd123 superconductors with the addition of Gd2Ba4MCuOx(M=Mo,Zr)显示文摘 | Xu Caixuan HuAnming | 2006 | Supercond Sci Techn2006，19，12： | 1 |
| 2 | Local Stability for an Inverse Coefficient Problem of a Fractional Diffusion Equation显示文摘Time-fractional diffusion equations are of great interest and importance on describing the power law decay for diffusion in porous media. In this paper, to identify the diffusion rate, i.e., the heterogeneity of medium, the authors consider an inverse coefficient problem utilizing finite measurements and obtain a local Hlder type conditional stability based upon two Carleman estimates for the corresponding differential equations of integer orders. | Caixuan REN Xiang XU | 2014 | Chinese Annals of Mathematics,Series B2014，35，3： | 1 |
| 3 | Genetic Variants in Cyclooxygenase-2 : Expression and Risk of Gastric Cancer and Its Precursors in a Chinese Population显示文摘 | Fen Liu Kaifeng Pan Xuemei Zhang Yang Zhang Lian Zhang Junling Ma Caixuan Dong Lin Shen Jiyou Li Dajun Deng Dongxin Lin Weicheng You | 2006 | Gastroenterology2006，，7： | 1 |
| 4 | A human antibody potently neutralizes RSV by targeting the conserved hydrophobic region of prefusion F显示文摘Respiratory syncytial virus(RSV) continues to pose serious threats to pediatric populations due to the lack of a vaccine and effective antiviral drugs. RSV fusion(F) glycoprotein mediates viral-host membrane fusion and is a key target for neutralizing antibodies. We generated 23 full-human monoclonal antibodies(hm Abs) against prefusion F protein(pre-F) from a healthy adult with natural RSV infection by single B cell cloning technique. A highly potent RSV-neutralizing hm Ab, named as 25-20, is selected, which targets a new site Φ-specific epitope. Site-directed mutagenesis and structural modelling analysis demonstrated that 25-20 mainly targets a highly conserved hydrophobic region located at the a4 helix and a1 helix of pre-F, indicating a site of vulnerability for drug and vaccine design. It is worth noting that 25-20 uses an unreported inferred germline(i GL) that binds very poorly to pre-F, thus high levels of somatic mutations are needed to gain high binding affinity with pre-F. Our observation helps to understand the evolution of RSV antibody during natural infection. Furthermore, by in silico prediction and experimental verification, we optimized 25-20 with KD values as low as picomolar range. Therefore, the optimized 25-20 represents an excellent candidate for passive protection against RSV infection. | Chunyan Yi Caixia Su Xiaoyu Sun Xiao Lu Chuanya Si Caixuan Liu Zhuo Yang Hong Yuan Yuying Huang Jing Wen Yonghui He Yaguang Zhang Liyan Ma Yao Cong Gan Zhao Zhiyang Ling Bin Wang Bing Sun | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 5 | Multiscale and hierarchical wrinkle enhanced graphene/Ecoflex sensors integrated with human-machine interfaces and cloud-platform显示文摘Current state-of-the-art stretchable/flexible sensors have received stringent demands on sensitivity,flexibility,linearity,and widerange measurement capability.Herein,we report a methodology of strain sensors based on graphene/Ecoflex composites by modulating multiscale/hierarchical wrinkles on flexible substrates.The sensor shows an ultra-high sensitivity with a gauge factor of 1078.1,a stretchability of 650%,a response time of~140 ms,and a superior cycling durability.It can detect wide-range physiological signals including vigorous body motions,pulse monitoring and speech recognition,and be used for monitoring of human respirations in real-time using a cloud platform,showing a great potential for the healthcare internet of things.Complex gestures/sign languages can be precisely detected.Human-machine interface is demonstrated by using a sensor-integrated glove to remotely control an external manipulator to remotely defuse a bomb.This study provides strategies for real-time/long-range medical diagnosis and remote assistance to perform dangerous tasks in industry and military fields. | Jian Zhou Xinxin Long Jian Huang Caixuan Jiang Fengling Zhuo Chen Guo Honglang Li YongQing Fu Huigao Duan | 2022 | npj Flexible Electronics2022，6，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员