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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Mapping sugar beet pectin acetylation B pattern 显示文摘 | Ralet M C Cabrera J C Bonnin E | 2005 | Phytochernistry2005，66，15： | 1 |
| 3 | The essential oil of Senecio graveolens(Compositae) : Chemical composition and antimicrobial activity tests 显示文摘 | PEREZ C AGNESE A M CABRERA J L | 1999 | Journal of Ethnopharmacology1999，66，2： | 1 |
| 4 | Acute exercise activates nuclear factor (NF)-kappaB signaling pathway in rat skeletal muscle 显示文摘 | JI L L GOMEZ CABRERA M C STEINHAFEL N | 2004 | FASEB J2004，18，13： | 1 |
| 5 | Selenium, copper, zinc, iron and manganese content of seven meat cuts from Hereford and Braford steers fed pas ture in Uruguay 显示文摘 | Cabrera M C Ramos A Saadoun A | 2010 | Meat Science2010，84，3： | 1 |
| 6 | Hot ductility behavior of boron microalloyed steels显示文摘 | LOPEZ-CHIPRES E MEJIA I MALDONADO C BEDOLLA-JACUINDE A CABRERA J M | 2007 | Mat Sci Eng A2007，，： | 1 |
| 7 | Resistance of the human immunodeficiency virus to the inhibitory action of negatively, charged albumins on virus binding to CD4显示文摘 | Cabrera C Witvrouw M Gutierrez A | 1999 | AIDS Res Hum Retroviruses1999，15，17： | 1 |
| 8 | Fungal endophytes and their role in plant protection显示文摘 | Gimenez C Cabrera R Reina M | 2007 | Curt Org Chem2007，11，： | 1 |
| 9 | Determination of tea components with antioxidant activity显示文摘 | Cabrera C Gimenez R Lopez M C | 2003 | Journal of Agricultural and Food Chemistry2003，51，15： | 1 |
| 10 | Economic values of ecological services from a mangrove ecosystem显示文摘 | Cabrera M A Seijo J C Euan J | 1998 | International Newsletter of Coastal Management1998，33，： | 1 |
| 11 | Oxidation of methanol on platinum, ruthenium and mixed Pt-M metais (M = Ru, Sn) : A theoretical study显示文摘 | ISHIKAWA Y LIAO M S CABRERA C R | 2000 | Surf Sci2000，463，1： | 1 |
| 12 | Genistein, a soy isoflavone, up - regulates expression of antioxi- dant genes: involvement of estrogen receptors, ERK1/2, and NFkappaB显示文摘 | BORR~S C GAMBINI J GOMEZ CABRERA M C | 2006 | FASEB J2006，20，12： | 1 |
| 13 | A mixed integer linear programming machinery selection model of muhifarm systems 显示文摘 | Carnarena E A Gracia C Cabrera Sisto J M | 2003 | Biosysetms Engineering2003，87，2： | 1 |
| 14 | Acute paraplegia following intravenous steroid theraphy in a ease of dural spinal arteriovenous fistula 显示文摘 | Cabrera M Paradas C Mfrquez C | 2008 | J Neurol2008，255，9： | 1 |
| 15 | Phase transformation analysis throughout an anhydrous fluorinebasod sol -gel YBCO processing route显示文摘 | Finlayson A P Mouganie T Cordero- Cabrera M C | 2007 | Materials Chemistry and Physics2007，105，： | 1 |
| 16 | Methanol oxidation at the electrochenfical codeposited Pt-Os composite electrode显示文摘 | Zhu Y M Cabrera C R | 2001 | Electrochemical and Solid-State Letters2001，4，4： | 1 |
| 17 | Analysis of pesticide residues in bananas harvested in the Canary Islands (Spain)显示文摘 | Hernández-Borges J Cabrera J C Rodriguez-Delgado M á etc | 2009 | Food Chemistry2009，113，1： | 1 |
| 18 | Protein restriction during fetal and neonatal development alters reproductive function and accelerates reproductive aging in female progeny显示文摘 | GUZMAN C CABRERA R CARDENAS M | 2006 | The Journal of Physiology2006，572，1： | 1 |
| 19 | Prolactin Induces Autoantibody Formation by PBL of Normal Individuals and SLE Patients显示文摘 | GUTIERREZ M A CABRERA C E CUELLAR M L | 1993 | Arthritis Rheum1993，36，2： | 1 |
| 20 | An overview of the nutri tional value of beef and lamb meat from South Ameri ea显示文摘 | Cabrera M C Saadoun A | 2014 | Meat Science2014，98，3： | 1 |
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