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| 1 | Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells. | Li QF Ou Yang GL Li CY Hong SG | 2000 | World Journal of Gastroenterology2000，6，5： | 19 |
| 2 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 3 | Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-beta signaling in mesangial cells显示文摘 | SONG CY KIM BC HONG HK | 2005 | Kidney Int2005，67，5： | 1 |
| 4 | The sweet potato sporamin promoter confers high- level phytase expression and improves organic phosphorus acquisition and tuber yield of transgenic potato 显示文摘 | Hong YF Liu CY Cheng KJ Hour AL Chan MT Tseng TH Chert KY Shaw JF Yu SM | 2008 | Plant Mol Biol2008，67，： | 1 |
| 5 | Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratino- cytes显示文摘 | Kok SH Hong CY Kuo MY | 2003 | Oral 0ncol2003，39，1： | 1 |
| 6 | Methyloxime-substituted aminopyrrolidine: a new surrogate for 7-basic group of quinolone 显示文摘 | Hong CY Kim YK Lee YH | 1998 | Bioorg Med Chem Lett1998，8，3： | 1 |
| 7 | Elevated expression of connective tissue growth factor in human atrial fibrillation and angiotensin lI- treated cardiomyoeytes 显示文摘 | Ko WC Hong CY Hou SM | 2011 | Circ J2011，75，7： | 1 |
| 8 | Laparoseopic left hemihepatectomy for left intrahepatic duct stones显示文摘 | Jeong CY Kim K J Hong SC | 2012 | J Korean Surg Snc2012，83，3： | 1 |
| 9 | Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotie to antiapoptotic protein ratio显示文摘 | Kok SH Cheng SJ Hong CY | 2005 | Cancer Lett2005，217，1： | 1 |
| 10 | Modulation of androgen receptor transactivation by the SWI3-related gene product ( SRG3 ) in multiple ways 显示文摘 | Hong CY Suh JH Kim K | 2005 | Mol Cell Biol2005，25，12： | 1 |
| 11 | Effect of anthraquinore derivatives on lipid peroxidation in rat heart mitochonclria:structure activity relationship 显示文摘 | Yeh SF Hong CY | 1995 | J Nst Prad1995，58，9： | 1 |
| 12 | Effect of anthraquinone derivatives on lipid peroxidation in rat heart mitochondria:structure-activity relationship显示文摘 | Huang SS Yeh SF Hong CY | 1995 | J Nat Prod1995，58，9： | 1 |
| 13 | Cellular and molecular mechanisms of atherosclerosis with mouse models显示文摘 | Ohashi RJ Mu Hong Yao QZ Chen CY | 2004 | Trends Cardiovasc Med2004，14，： | 1 |
| 14 | Inducible cyclooxygenase and interleukin 6 geneexpressions in nasal polyp fibroblasts:possible implication in the pathogenesis of nasalpolyposis显示文摘 | LIU CM HONG CY SHUN CT | 2002 | Arch-Otolaryngol-Head-Neck-Surg2002，128，8： | 1 |
| 15 | Measurement and Pharmacckinetics study of tetramethylpyrazine in rat blood and its regional brain tissue by high-performonce liquicl Chomatography显示文摘 | Liang CC Hong CY Chen CF | 1999 | Chromatogr Biomed Sci Appi1999，724，2： | 1 |
| 16 | Urinary alpha - 1 - microglobulin as a marker of nephropathy in type 2 diabetic Asian subjects in Singapore 显示文摘 | Hong CY Hughes K Chia KS | 2003 | Diabetes Care2003，26，2： | 1 |
| 17 | Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes显示文摘 | Kok SH Hong CY Kuo MY Lee CH Lee JJ Lou IU | 2003 | Oral Oncol2003，39，1： | 1 |
| 18 | Novel fluoroquinolone antibacterial agents containing oxime-substituted(aminomethyl) pyrrolidines: synthesis and antibacterial activity of 7- (4- (aminomethyl)-3- (methoxyimino)pyrrolidin-1 -yl) - 1 -cyclopropyl-6- fluoro-4-oxo- 1,4-dihydro naphthyridine-3-carboxylic acid (LB20304) 显示文摘 | Hong CY Kim YK Chang JH | 1997 | J Med Chem1997，40，22： | 1 |
| 19 | Urinary protein ex- cretionin Type 2 diabetes with complications 显示文摘 | Hong CY Chia KS Ling SL | 2010 | JDia betes Complications2010，14，5： | 1 |
| 20 | Increased aortic endothelial cell death and enhanced transendothelial maoromoleculr transport in streptozotocin-diabetic rat显示文摘 | Hong CY Chang MS | 1993 | Diabetoligia1993，36，： | 1 |
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