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| 1 | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop显示文摘The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin(IL)-1β, and is one of the main causes of intervertebral disc degeneration(IVDD). NLR pyrin domain containing 3(NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its roles in IVDD are still not well understood and require more examination. First, we demonstrated that melatonin delayed the progression of IVDD and relieved IVDD-related low back pain in a rat needle puncture IVDD model;moreover, NLRP3 inflammasome activation(NLRP3, p20, and IL-1β levels) was significantly upregulated in severely degenerated human discs and a rat IVDD model. Subsequently, an IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop was found in nucleus pulposus(NP) cells that were treated with IL-1β. In these cells, expression of NLRP3 and p20 was significantly increased, NF-κB signaling was involved in this regulation, and mitochondrial reactive oxygen species(mt ROS)production increased. Furthermore, we found that melatonin disrupted the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop in vitro and in vivo. Melatonin treatment decreased NLRP3, p20, and IL-1β levels by inhibiting NF-κB signaling and downregulating mt ROS production. Finally, we showed that melatonin mediated the disruption of the positive feedback loop of IL-1β in vivo. In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD. | Fan Chen Guowei Jiang Hui Liu Zemin Li Yuxin Pei Hua Wang Hehai Pan Haowen Cui Jun Long Jianru Wang Zhaomin Zheng | 2020 | Bone Research2020，8，2： | 18 |
| 2 | BUD2,encoding an S-adenosylmethionine decarboxylase,is required for Arabidopsis growth and development显示文摘Polyamines 在在植物,而是他们的准确角色调整各种各样的发展过程被含有并且他们怎么管理这些过程尚待逃犯。我们这里报导浓密的 Arabidopsis 和矮子异种, bud2,哪个从编码 S-adenosylmethionine decarboxylases (SAMDC ) 的小基因家庭的一个成员的完全的删除的结果为在 polyamine 简历的不可缺少的中介的形成必要合成小径。bud2 植物在开花期,根,和叶柄扩大了脉管的系统,并且 polyamines 的改变的动态平衡。bud2 和 samdc1 的双异种,另一个 SAMDC 成员的击倒的异种,是胚胎致命,证明 SAMDC 为植物胚胎开始是必要的。我们的结果建议 polyamines 为更高的植物的正常生长和发展被要求。 | Chunmin Ge Xia Cui Yonghong Wang Yuxin Hu Zhiming Fu Dongfen Zhang Zhukuan Cheng Jiayang Li | 2006 | Cell Research2006，16，5： | 14 |
| 3 | Promoting ring-opening efficiency for suppressing toxic intermediates during photocatalytic toluene degradation via surface oxygen vacancies显示文摘Aromatic ring-opening process is well recognized as the rate-determining step for catalytic toluene degradation. In photocatalytic toluene degradation, the toxic intermediates w让h harmful effects may be generated. To clarify the precise reaction mechanism and control the toxic intermediates generation, a closely combined in situ DRIFTS and DFT calculation is utilized to address these important issues. We construct the BiOCl w让h oxygen vacancies (OVs) and reveal the structure of OVs. The defect level caused by oxygen vacancies could promote the light adsorption and charge separation, which further boosts the activation of ring-opening species and enhances the generation process of free radicals. The reaction energy barriers of four possible ring-opening processes on defective BiOCl (OVBOC) are all declined in comparison with perfect BiOCl (BOC). The existence of oxygen vacancies could smooth the ratedetermining step so the ring-opening efficiency of photocatalytic toluene degradation is highly increased. Most importantly, the methyl species would be further oxidized and tend to open the benzene-ring at benzoic acid on BOC while the ring would be broken at the benzyl alcohol on OVBOC. These results indicate that the toluene degradation pathway is shortened via the surface OVs, which enables the production of radicals with high oxidation capability for the accelerated chain scission of the ring-opening intermediates. Finally, the efficiency of the key ring-opening process could be enormously improved and toxic intermediates are effectively restrained. The present work could provide new insights into the design of high-performance photocatalysts for efficient and safe degradation of VOCs in air. | Xing'an Dong Wen Cui Hong Wang Jieyuan Li Yanjuan Sun Haiqiang Wang Yuxin Zhang Hongwei Huang Fan Dong | 2019 | Science Bulletin2019，64，10： | 9 |
| 4 | Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells显示文摘Objective:Although T-cell immunoglobulin and mucin-domain containing molecule-3(Tim-3)has been recognized as a promising target for cancer immunotherapy,its exact role in breast cancer has not been fully elucidated.Methods:Tim-3 gene expression in breast cancer and its prognostic significance were analyzed.Associated mechanisms were then explored in vitro by establishing Tim-3-overexpressing breast cancer cells.Results:In a pooled analysis of The Cancer Genome Atlas(TCGA)database,Tim-3 gene expression levels were significantly higher(P<0.001)in breast cancer tissue,compared with normal tissues.Tim-3 was a prognosis indicator in breast cancer patients[relapse-free survival(RFS),P=0.004;overall survival(OS),P=0.099].Tim-3 overexpression in Tim-3 low breast cancer cells promoted aggressiveness of breast cancer cells,as evidenced by enhanced proliferation,migration,invasion,tight junction deterioration and tumor-associated tubal formation.Tim-3 also enhanced cellular resistance to paclitaxel.Furthermore,Tim-3 exerted its function by activating the NF-κB/STAT3 signalling pathway and by regulating gene expression[cyclin D1(CCND1),C-Myc,matrix metalloproteinase-1(MMP1),TWIST,vascular endothelial growth factor(VEGF)upregulation,concomitant with Ecadherin downregulation).Lastly,Tim-3 downregulated tight junction-associated molecules zona occludens(ZO)-2,ZO-1 and occludin,which may further facilitate tumor progression.Conclusions:Tim-3 plays an oncogenic role in breast cancer and may represent a potential target for antitumor therapy. | Yizi Cong Yuxin Cui Shiguang Zhu Jianqiao Cao Haidong Zou Tracey AMartin Guangdong Qiao Wenguo Jiang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 7 |
| 5 | Iron-mediated cross dehydrogenative coupling(CDC) of terminal alkynes with benzylic ethers and alkanes显示文摘Iron-mediated sp-sp3 C-C bond formation through the cross dehydrogenative coupling(CDC) of terminal alkynes with benzylic ethers or alkanes has been developed.The inexpensive iron salt is used as the catalyst to make this transformation environmentally benign.Iron-mediated sp-sp3 C-C bond formation through the cross dehydrogenative coupling(CDC) of terminal alkynes with benzylic ethers or alkanes has been developed.The inexpensive iron salt is used as the catalyst to make this transformation environmentally benign. | XIANG Shi-Kai ZHANG Bo ZHANG Li-He CUI YuXin JIAO Ning | 2012 | Science China Chemistry2012，55，1： | 6 |
| 6 | PTEN regulates RPA1 and protects DNA replication forks显示文摘肿瘤 suppressor PTEN 通过多重机制调整细胞的活动和控制染色体稳定性。在这研究,我们报导 PTEN 为对复制应力的 DNA 复制叉的保护是必要的。我们证明 PTEN 的那删除在叉拖延跟随 hydroxyurea 导致的核苷酸弄空之上导致复制叉倒塌和 chromosomal 不稳定性。PTEN 身体上与复制蛋白质 A 被联系 1 (RPA1 ) 经由 RPA1 C 终端领域。暴风雨和 iPOND 表明 PTEN 在复制地点是局部性的并且在复制叉上支持 RPA1 累积。PTEN 成员调停的 deubiquitinase OTUB1 RPA1 deubiquitination。RPA1 删除授与象与复制叉拖延在 PTEN 猛烈房间观察了那一样的显型。PTEN 和 RPA1 的表示在 colorectal 癌症显示出强壮的关联。RPA1 的异质接合的混乱在老鼠支持 tumorigenesis。这些结果证明 PTEN 为 DNA 复制叉保护是必要的。我们建议 RPA1 是在叉保护的 PTEN 功能的一个目标并且 PTEN 通过 DNA 复制的规定维持染色体稳定性。 | Guangxi Wang Yang Li Pan Wang Hui Liang Ming Cui Minglu Zhu Limei Guo Qian Su Yujie Sun Michael A McNut Yuxin Yin | 2015 | Cell Research2015，25，11： | 6 |
| 7 | Multiobjective optimal dispatch of microgrid based on analytic hierarchy process and quantum particle swarm optimization显示文摘Owing to the rapid development of microgrids(MGs)and growing applications of renewable energy resources,multiobjective optimal dispatch of MGs need to be studied in detail.In this study,a multiobjective optimal dispatch model is developed for a standalone MG composed of wind turbines,photovoltaics,diesel engine unit,load,and battery energy storage system.The economic cost,environmental concerns,and power supply consistency are expressed via subobjectives with varying priorities.Then,the analytic hierarchy process algorithm is employed to reasonably specify the weight coefficients of the subobjectives.The quantum particle swarm optimization algorithm is thereafter employed as a solution to achieve optimal dispatch of the MG.Finally,the validity of the proposed model and solution methodology are con firmed by case studies.This study provides refere nee for mathematical model of multiojective optimizati on of MG and can be widely used in current research field. | Yuxin Zhao Xiaotong Song Fei Wang Dawei Cui | 2020 | Global Energy Interconnection2020，3，6： | 6 |
| 8 | Comparison on effect of hydrophobicity on the antibacterial and antifungal activities of α-helical antimicrobial peptides显示文摘HPRP-A1, a 15-mer α-helical cationic peptide, was derived from N-terminus of ribosomal protein L1 (RpL1) of Helicobacter pylori. In this study, HPRP-A1 was used as a framework to obtain a series of peptide analogs with different hydrophobicity by single amino acid substitutions in the center of nonpolar face of the amphipathic helix in order to systematically study the effect of hydrophobicity on biological activities of -helical antimicrobial peptides. Hydrophobicity and net charge of peptides played key roles in the biological activities of these peptide analogs; HPRP-A1 and peptide analogs with relative higher hydrophobicity exerted broad spectrum antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and pathogenic fungi, but also showed stronger hemolytic activity; the change of hydrophobicity and net charge of peptides had similar effects with close trend and extent on antibacterial activities and antifungal activities. This indicated that there were certain correlations between the antibacterial mode of action and the antifungal mode of action of these peptides in this study. The peptides exhibited antimicrobial specificity for bacteria and fungi, which provided potentials to develop new antimicrobial drugs for clinical practices. | ZHAO LianJing HUANG YiBing GAO Song CUI Yan HE Dan WANG Li CHEN YuXin | 2013 | Science China Chemistry2013，56，9： | 3 |
| 9 | Inhibition of the toxic byproduct during photocatalytic NO oxidation via La doping in ZnO显示文摘It is of a great challenge to develop semiconductor photocatalysts with potential possibilities to simultaneously enhance photocatalytic efficiency and inhibit generation of toxic intermediates.In this study,we developed a facile method to induce the La doping and cationic vacancie(V(Zn))on ZnO for the highly efficient complete NO oxidation.The photocatalytic NO removal efficiency increases from 36.2%to 53,6%.Most importantly,a significant suppressed NO2 production also has been realized.According to the DFT calculations,ESR spectra and in situ FTIR spectra,the introduction of La^3+induce the redistribution of charge carriers in La-ZnO,which promote the production of·O2^- and lead to the formation of V(Zn)for the formation of·OH,contributing to the complete oxidation of NO to nitrate.Besides,the conversion pathway of photocatalytic NO oxidation has been elaborated,This work paves a new way to simultaneously realize the photocatalytic pollutants removal and the inhibition of toxic intermediates generation for efficient and safe air purification. | Chaowei Yuan Wen Cui Yanjuan Sun Jiadong Wang Ruimin Chen Jin Zhang Yuxin Zhang Fan Dong | 2020 | Chinese Chemical Letters2020，31，3： | 3 |
| 10 | Integrity constraints in OWL ontologies based on grounded circumscription显示文摘为有完整限制的基于逻辑的知识库的扩展是相当流行的。我们提出了一种选择为用网本体论语言(猫头鹰) 的正直限制的分析的标准在关上的世界假设下面的本体论。根据这标准,扎根的界限被使用由在正直限制最小化谓语的延期在猫头鹰本体论和正直限制的满足定义正直限制。根据正直限制的语义,我们提供为决定扩大本体论的一致性健全、完全的一个修改场面算法。最后,正直限制确认被变换成扩大本体论的相应一致性。把我们的途径与存在正直限制确认作比较来临,我们证明我们的途径的结果比在某些情况中的另外的途径是根据用户要求的更多。 | Dantong OUYANG | 2013 | Frontiers of Computer Science2013，7，6： | 2 |
| 11 | Research and Applications of Semi-solid Processing显示文摘It has been more than ten years since the semi-solid processing (SSP) technique was put into commercial applications in the world. A lot of work on semi-solid metals (SSM) including their preparation, reheating and semi-solid forming has been done in China. In order to produce the high quality die-casting, a novel innovation that modifies the present machines based on the SSP technique was proposed. Semi-solid die-casting on modified casting machines can manufacture parts with more excellent quality than those produced by squeeze casting. It was found that the defects such as 'elephant foot' and 'periphery liquid metal loss' during reheating could be avoided through controlling the non-de- ndritic sthectgre of billets and optimizing the reheating process. The processing parameters and mold designs of semi-so- lid die-casting are fairly different from those of liquid die-casting. | Kui Zhang, Jun Xu, Likai Shi, Daijin Cui, Yuxin Zheng (General Research Institute for Nonferrous Metals, Beijing 100088, China Dongfeng Motor Corp., Shiyan 442001, China) | 2001 | Rare Metals2001，20，2： | 2 |
| 12 | Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses显示文摘Pharmaceutical analysis is a discipline based on chemical, physical, biological, and information technologies. At present, biotechnological analysis is a short branch in pharmaceutical analysis;however, bioanalysis is the basis and an important part of medicine. Biotechnological approaches can provide information on biological activity and even clinical efficacy and safety, which are important characteristics of drug quality. Because of their advantages in reflecting the overall biological effects or functions of drugs and providing visual and intuitive results, some biotechnological analysis methods have been gradually applied to pharmaceutical analysis from raw material to manufacturing and final product analysis,including DNA super-barcoding, DNA-based rapid detection, multiplex ligation-dependent probe amplification, hyperspectral imaging combined with artificial intelligence, 3D biologically printed organoids,omics-based artificial intelligence, microfluidic chips, organ-on-a-chip, signal transduction pathwayrelated reporter gene assays, and the zebrafish thrombosis model. The applications of these emerging biotechniques in pharmaceutical analysis have been discussed in this review. | Shilin Chen Zheng Li Sanyin Zhang Yuxin Zhou Xiaohe Xiao Pengdi Cui Binjie Xu Qinghe Zhao Shasha Kong Yuntao Dai | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 13 | Occurrence, variations, and risk assessment of neonicotinoid insecticides in Harbin section of the Songhua River, northeast China显示文摘Neonicotinoid insecticides(NNIs)have been intensively used and exploited,resulting in their presence and accumulation in multiple environmental media.We herein investigated the current levels of eight major NNIs in the Harbin section of the Songhua River in northeast China,providing the first systematic report on NNIs in this region.At least four NNIs in water and three in sediment were detected,with total concentrations ranging from 30.8 to 135 ng L^(-1) and from 0.61 to 14.7 ng g^(-1) dw,respectively.Larger spatial variations in surface water NNIs concentrations were observed in tributary than mainstream(p<0.05)due to the intensive human activities(e.g.,horticulture,urban landscaping,and household pet flea control)and the discharge of wastewater from many treatment plants.There was a significant positive correlation(p<0.05)between the concentrations of residual imidacloprid(IMI),clothianidin(CLO),and S4NNIs in the sediment and total organic carbon(TOC).Due to its high solubility and low octanol-water partition coefficient(Kow),the sediment-water exchange behavior shows that NNIs in sediments can re-enter into the water body.Human exposure risk was assessed using the relative potency factor(RPF),which showed that infants have the highest exposure risk(estimated daily intake(SIMIeq EDI):31.9 ng kg^(-1) bw$d^(-1)).The concentration thresholds of NNIs for aquatic organisms in the Harbin section of the Songhua River were determined using the species sensitivity distribution(SSD)approach,resulting in a value of 355 ng L^(-1) for acute hazardous concentration for 5%of species(HC5)and 165 ng L^(-1) for chronic HC5.Aquatic organisms at low trophic levels were more vulnerable to potential harm from NNIs. | Zhikun Liu Song Cui Leiming Zhang Zulin Zhang Rupert Hough Qiang Fu Yi-Fan Li Lihui An Mingzhi Huang Kunyang Li Yuxin Ke Fuxiang Zhang | 2021 | Environmental Science and Ecotechnology2021，，4： | 2 |
| 14 | Seabed deposition and erosion change and influence factors in the Yangshan Deepwater Port over the years显示文摘The seabed scouring and silting are very important to the construction of port and waterway engineering.Seabed deposition and erosion change is complicated due to the influence of sediment supply,human activities and other factors.The Yangshan Deepwater Port is the new deep water harbor,which is an important part of the Shanghai International Shipping Service Center.Its construction has received much attention.At present,the water depth from the 1st to the 3rd harbor district is currently suitable under regular dredging and tidal current action.The fourth harbor district will be built in the world’s largest fully-automated deep water wharf.In the study,bathymetry change of the entire sea area of the Yangshan Deepwater Port and the 4th harbor district(i.e.,PhaseⅣproject)waters were analyzed quantitatively using multiyear bathymetric,hydrological and sediment data.The results show that from 1998 to 2010,seabed changes are characterized by large volumes of erosion and sedimentation,which the southern part was deposited and the northern part was eroded in the inner harbor waters,but the seabed of the Kezhushan inlet was eroded.Seabed changes of PhaseⅣproject waters generally show a scour tendency in recent few years with the annual scour rate about 0.7 m.Among the many factors,the existence of Kezhushan inlet and its influence of the western water flow play an important positive role in water depth changes under the ebb tide action. | Shuhua Zuo Hualiang Xie Xiaoming Ying Cheng Cui Yuxin Huang Huaiyuan Li Mingxiao Xie | 2019 | Acta Oceanologica Sinica2019，38，7： | 2 |
| 15 | On-farm evaluation of an in-season nitrogen management strategy based on soil N min test显示文摘 | Zhenling Cui Fusuo Zhang Xinping Chen Yuxin Miao Junliang Li Liwei Shi Jiufei Xu Youliang Ye Chunsheng Liu Zhiping Yang Qiang zhang Shaomin Huang Dejun Bao | 2007 | Field Crops Research2007，，1： | 1 |
| 16 | Two Arabidopsis Receptor-like Cytoplasmic Kinases SZE1 and SZE2 Associate with the ZAR1-ZED1 Complex and Are Required for Effector-Triggered Immunity显示文摘Plants utilize intracellular nucleotide-binding leucine-rich repeat domain-containing receptors (NLRs) to recognize pathogen effectors and induce a robust defense response named effector-triggered immunity (ETI). The Arabidopsis NLR protein HOPZ-ACTIVATED RESISTANCE 1 (ZAR1) forms a precomplex with HOPZ-ETI-DEFICIENT 1 (ZED1),a receptor-like cytoplasmic kinase (RLCK) XII-2 subfamily member, to recognize the Pseudomonas syringae effector HopZ1 a. We previously described a dominant mutant of Arabi-dopsis ZED1, zed1-D, which displays temperature-sensitive autoimmunity in a ZAR1-dependent manner. Here, we report that the RLCKs SUPPRESSOR OF ZED1-D1 (SZE1) and SZE2 associate with the ZAR1-ZED1 complex and are required for the ZED7-D-activated autoimmune response and HopZ1a-triggered immunity. We show that SZE1 but not SZE2 has autophosphorylation activity, and that the N-terminal myristoylation of both SZE1 and SZE2 is critical for their plasma membrane localization and ZED1-D-activated autoimmunity. Furthermore, we demonstrate that SZE1 and SZE2 both interact with ZAR1 to form ja functional complex and are required for resistance against P. syringae pv. tomato DC3000 ex-pressing HopZIa. We also provide evidence that SZE1 and SZE2 interact with HopZ1a and function together with ZED1 to change the intramolecular interactions of ZAR1, leading to its activation. Taken together, our re-sults reveal SZE1 and SZE2 as critical signaling components of HopZ1a-triggered immunity. | Cheng Liu Dayong Cui Jingbo Zhao Na Liu Bo Wang Jing Liu Enjun Xu Zhubing Hu Dongtao Ren Dingzhong Tang Yuxin Hu | 2019 | Molecular Plant2019，12，7： | 1 |
| 17 | Light-Induced Dynamic Stability of Oxygen Vacancies in BiSbO_(4) for Efficient Photocatalytic Formaldehyde Degradation显示文摘Defect engineering has been regarded as a versatile strategy to maneuver the photocatalytic activity.However,there are a few studies concerning how to maintain the stability of defects,which is important to ensure sustainable photocatalytic performance.Here,a novel strategy to modulate the structural properties of BiSbO_(4)using light-induced dynamic oxygen vacancies is reported by us for efficient and stable photocatalytic oxidation of formaldehyde.Interestingly,the continuous consumption and replenishment of vacancies(namely dynamic vacancies)ensure the dynamic stability of oxygen vacancies,thus guaranteeing the excellent photocatalytic stability.The oxygen vacancies could also accelerate the electron migration,inhibit the photogenerated electron/hole recombination,widen the light absorption spectra,and thus improve the photocatalytic formaldehyde removal performance.Combined with the results of in situ DRIFTS,the reaction mechanism for each step of formaldehyde oxidation is revealed.As supported by DFT calculation of Gibbs free energy,the introduction of oxygen vacancies into BiSbO_(4)can promote spontaneous process of formaldehyde oxidation.Our work highlights a promising approach for stabilizing the defects and proposes the photocatalytic reaction mechanism in combination with the thermodynamic functions. | Maoxi Ran Wen Cui Kanglu Li Lvcun Chen Yuxin Zhang Fan Dong Yanjuan Sun | 2022 | Energy & Environmental Materials2022，5，1： | 1 |
| 18 | Transform- ing agriculture in China: from solely high yield to both high yield and high resource use efficiency 显示文摘 | Shen Jianbo Cui Zhenling Miao Yuxin | 2013 | Global Food Security2013，2，1： | 1 |
| 19 | Bursty event detection from collaborative tags显示文摘 | Junjie Yao Bin Cui Yuxin Huang | 2012 | World Wide Web2012，15，： | 1 |
| 20 | Advances in wide-tuning and narrow-linewidth external-cavity diode lasers显示文摘The external-cavity diode laser is advantageous in terms of low noise,high side-mode suppression ratio,high temperature stability,simple structure,and low cost,which has been the preferred scheme to realize wide-tuning and narrow-linewidth characteristics.Thus,it has been widely used in optical communication,lidar,environmental monitoring,spectral analysis,optical coherence tomography,and other frontier fields.Herein,we introduce the technical scheme and review the development status of wide-tuning and narrow-linewidth external-cavity diode lasers in detail.Primarily,the structure,working principles,and performance characteristics of external-cavity diode lasers are deeply analyzed according to different structures.The structural characteristics,key technologies,optical performance and application fields of state-of-theart studies in recent years are discussed.Finally,the challenges and potential development prospects of wide-tuning and narrow-linewidth external-cavity diode lasers are analyzed and discussed. | Qiang CUI Yuxin LEI Yongyi CHEN Cheng QIU Ye WANG Dexiao ZHANG Lutai FAN Yue SONG Peng JIA Lei LIANG Yubing WANG Li QIN Yongqiang NING Lijun WANG | 2022 | Science China(Information Sciences)2022，65，8： | 1 |
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