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| 1 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 2 | Occupational slip,trip, and fall- related injuries- can the contribution of slipperiness be isolated 显示文摘 | Courtney T K Sorock G S Manning D P | 2001 | Ergonomics2001，44，13： | 1 |
| 3 | Prevalence of low back pain in three occupational groups in Shanghai,People's Republic of China显示文摘 | Jin K Sorock G S Courtney T K | 2004 | Journal of Safety Research2004，，01： | 1 |
| 4 | The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia显示文摘 | Stradal T Courtney KD Rottner K | 2004 | Curr Biol2004，11，11： | 1 |
| 5 | CO2-in- duced ocean acidification impairs calcification in the tropical urchin Echinometra viridis显示文摘 | COURTNEY T WESTFIELD I RIES J B | 2013 | Journal of Ex- perimental Marine Biology and Ecology2013，440，1： | 1 |
| 6 | Indicators of soil formation in restored bauxite residues显示文摘 | COURTNEY R HARR1NGTON T BYRNE K A | 2013 | Ecological Engineering2013，58，： | 1 |
| 7 | Synthesis of Cu-NbC nanocomposites bymechanical alloying显示文摘 | Murphy B R Courtney T H | 1994 | NanoStructured Materials1994，4，： | 1 |
| 8 | Chromite-A cost-effective refractory raw material for refractories in various metallurgical applications 显示文摘 | McEwan N Courtney T Parry R A | 2012 | Refract Eng2012，，6： | 1 |
| 9 | Nipple discharge: a sign of breast cancer? 显示文摘 | Richards T Hunt A Courtney S | 2007 | Ann R Coil Surg Engl2007，89，2： | 1 |
| 10 | Reaction Rates During Mechanical Alloying 显示文摘 | AIKIN B J M COURTNEY T H etal | 1991 | Materials Science and Engineering1991，，147： | 1 |
| 11 | Effects of high pressure on the viability, morphology, lysis, and cell wall hydrolase activity of Lactococcus lactis subsp, cremoris显示文摘 | MALONE A S S T H COURTNEY P D | 2002 | Applied and Environmental Microbiology2002，68，9： | 1 |
| 12 | Process Modelling of Mechanical Alloying (Overview)显示文摘 | Courtney T H | 1995 | MaterialsTransactions JIM1995，36，2： | 1 |
| 13 | Using PCR amplification to increase the confidence level of Salmonella Typhimurium DNA microarray chip hybridization 显示文摘 | COURTNEY S MOSSOBA M E HAMMACK T S | 2006 | Mol Cell Probes2006，20，： | 1 |
| 14 | Gravity-induced sedimentation during melting and liquid phase sintefing of Pb-Sn alloys 显示文摘 | Du Y Courtney T H Lu S Z | 2003 | Acta Materialia2003，51，2： | 1 |
| 15 | The kinetics of composite particle formation during mechanical alloying 显示文摘 | AIKIN B J M COURTNEY T H | 1993 | Metallurgical Transactions A1993，24，3： | 1 |
| 16 | The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels显示文摘 | Griffin Courtney T Curtis Carol D Davis Reema B | 2011 | Proc Natl Acad Sci USA2011，108，6： | 1 |
| 17 | Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants显示文摘 | Robert B Perni Luc J Farmer Kevin M Cottrell John J Court Lawrence F Courtney David D Deininger Cynthia A Gates Scott L Harbeson Joseph L Kim Chao Lin Kai Lin Yu-Ping Luong John P Maxwell Mark A Murcko Janos Pitlik B.Govinda Rao Wayne C Schairer Roger D T | 2004 | Bioorganic & Medicinal Chemistry Letters2004，，8： | 1 |
| 18 | Modeling of Mechanical al loying : Part I : Deformation, coalescence and fragmenta tion Mechanisms显示文摘 | Maurice D Courtney T H | 1994 | Metallurgical and Material Trans-actions1994，25，： | 1 |
| 19 | Design and analysis of tissue engineering Scaffolds that mimic soft tissue mechanical anisotropy 显示文摘 | Courtney T Sacks MS Stankus J | 2006 | Biomaterials2006，27，19： | 1 |
| 20 | The kinetic of composite particle formation during mechanical alloying 显示文摘 | Aikin B J M Courtney T H | 1993 | Metall Trans1993，24，3： | 1 |
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