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61篇 您的检索式:作者名="COULSON A F"
    题名 作者 年代 出处 被引量
1Ⅰ期癌症患者切除淋巴结内隐匿性微小转移癌灶的检查及其临床病理意义显示文摘目的 检查癌症患者切除淋巴结内有无微小癌转移 ,具有临床、病理重要性。方法 350例 期癌症患者包括非小细胞肺癌 94例 ,乳腺癌 112例 ,食管癌 115例及外阴癌 2 9例病理报告无癌转移的淋巴结 3715枚。应用单克隆抗细胞角蛋白 ( AE1/ AE3)、抗上皮细胞膜 ( EMA) ,及多克隆抗角蛋白抗体进行免疫组化染色重新检查。结果 所有病例的 32 .3% ( 113/ 350 )、被检淋巴结的 5.5%( 2 0 3/ 3715)有淋巴结内隐匿性肿瘤转移。肺癌患者及被检淋巴结的阳性率均比其他肿瘤高。肺鳞癌58%、腺癌 53.8%的淋巴结为阳性 ,分别比食管鳞癌 2 2 .5%、外阴鳞癌 10 .3%及乳腺癌 2 7.7%高 ( P<0 .0 5)。部分乳腺癌患者术后随访显示 :淋巴结阳性患者比阴性者预后更差 ( P<0 .0 5)。结论 说明免疫组化技术可大大提高淋巴结微小癌转移的检出率 ,其阳性率的不同可能与患者的临床经过甚至癌患者的死亡率相关联。陈朝伦 卢晓梅 黄绒 黎音 古丽娜尔 沈宝茵 A J Cochran D R Wen W F Coulson 1997中华肿瘤杂志1997,19,1:16
2Nucleotide sequence of bacteriophage lambda DNA显示文摘Sanger F Coulson A R Hong G F 1982J Mol Biol1982,162,:1
3A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase 显示文摘Sanger F Coulson A R 1975MolBiol1975,94,:1
4A standard numbering scheme for the class A beta-lac- tamases显示文摘AMBLER R P COULSON A F FRERE J M 1991Biochemical Journal1991,276,1:1
5A standard numbering scheme for the class A β-lactamases显示文摘Ambler R P Coulson A F W Frére J M 1991Biochem J1991,276,:1
6DNA sequencing with chain-terminating inhibitors显示文摘SANGER F NICKLEN S COULSON A R 0,,12:1
7The significance of protein sequence similarities显示文摘Collins J F Coulson A F Lyall A 1988Comput Appl Biosci1988,4,:1
8DNA sequencing with chain-terminating inhibitors显示文摘SANGER F NICKLEN S COULSON A R 1977Proc Natl Acad Sci U S A1977,74,:1
9A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase显示文摘Sanger F Coulson A 1975J Mol Biol1975,94,:1
10DNA sequencing with chain-terminating inhibitor显示文摘Sanger F Nicklen S Coulson A R 1977Proc Natl Acad Sci USA1977,74,12:1
11Nucleotide sequence of bacteriophage λDNA显示文摘 Coulson A R Hong G F Hill D F Petersen G B 1982J Mol Biol1982,162,:1
12DNA sequencing with chain-terminating inhibitors显示文摘SANGER F NICKLEN S COULSON A R 1977Proceedings of the National Academy of Sciences oftheUnited States of America1977,74,12:1
13DNA sequencing with chain terminating inhibitors显示文摘Sanger F Nicklen S Coulson A R 1977Proceedings of the National Academy of Sciences1977,74,12:1
14DNA ,sequencing with chain - terminating inhibitors显示文摘SANGER F NICKLEN S COULSON A R 1977Proc Natl Acad Sci U S A1977,74,12:1
15DNA sequencing with chain-terminating inhibitors显示文摘Sanger F Nicklen S Coulson A R 1977Proc Natl Acad Sci U S A1977,74,12:1
16DNA sequencing with chain-terminating inhibitors 显示文摘SANGER F NICKLEN S COULSON A R 1977Proc Natl Acad Sci U S A1977,74,12:1
17DNA sequencing with chaiw terminating inhibitors 显示文摘Sanger F Nicklen S Coulson A R 1977Proceedings of the National Acade- my of Sciences1977,74,12:1
18DNA sequencing with chain-terminating inhibitors显示文摘Sanger F Nicklen S Coulson A R 1977PNAS1977,74,:1
19DNA sequencing with chain-termination inhibitors显示文摘Sanger F Nicklen S Coulson A R 0,,:1
20DNA sequencing with chain-terminating inhibitors显示文摘Sanger F Nicklen S Coulson A R 1977PNAS1977,74,12:1
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