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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | Tuberosity malposition and migration: Reasons for poor outcomes after hemiarthroplasty for displaced fractures of the proximal humerus显示文摘 | P Boileau S.G Krishnan L Tinsi G Walch J.S Coste D Molé | 2002 | Journal of Shoulder and Elbow Surgery2002，，5： | 2 |
| 4 | Experimental study on demineralized bone matrix and coral as bone graft substitutes in maxillofacial surgery显示文摘 | Dupoirieux L Costes V Jammet P | 1994 | Int J Oral Maxillofac Surg1994，23，14： | 1 |
| 5 | Stomatal regulation of photosynthesis in apple leaves: evidence for different water-use strategies between two euhivars显示文摘 | Massonnet C Costes E Rambal S Dreyer E Regnard J L | 2007 | Annals of Botany2007，100，6： | 1 |
| 6 | Overview of Fire Retardant Meehanisms显示文摘 | Camino G Cost L Luda Di Cortemiglia M P | 1991 | Polymer Degradation and Stability1991，33，2： | 1 |
| 7 | Analyzing fruit tree architecture: implications for tree management and fruit production显示文摘 | Costes E Lauri P E Regnard J L | 2006 | Hortieulatral Reviews2006，，32： | 1 |
| 8 | Hepatic artery thrombosis after liver transplantation: diagnosis with spiral CT显示文摘 | Legmann P Costes V Tudoret L | 1995 | AJR1995，164，1： | 1 |
| 9 | Experimental study on demineralized bone matrix and coral as bone graft substitutes in maxillofacial surgery显示文摘 | Dupoirieux L Costes V Jammet P | 1994 | Int J Oral Maxillofac Surg1994，23，： | 1 |
| 10 | 3D flow around a rectangular cylinder:a computational study显示文摘 | BRUNO L FRANSOS D COSTE N | | 0，，67： | 1 |
| 11 | Effects of neutron irradiation on Nd-Fe-B magnetic properties显示文摘 | J R COST R D BROWN A L GIORGI | 1988 | IEEE Trans Mag1988，24，3： | 1 |
| 12 | Functional endoscopic sinus surgery for isolated sphenoid sinus diseases显示文摘 | GILAIN L AIDAN D COSTE A | 1994 | Head Neck1994，16，： | 1 |
| 13 | Chemotherapy of advanced small- bowel adenocarcinoma:a multicenter AGEO study显示文摘 | Zaanan A Costes L Gauthier M | 2010 | Ann Oncol2010，21，9： | 1 |
| 14 | Measurement of social communication skills of children with autism spectrum disorders during interactions with typical peers显示文摘 | Murdock L C Cost H C Tieso C | | 0，，03： | 1 |
| 15 | Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case control population based study in France显示文摘 | Bouyer l Coste J Shoiaei T | 2003 | Am J Epidemi- ol2003，157，3： | 1 |
| 16 | High power ultrasound effects on lipid oxidation of refined sunflower oil显示文摘 | Chemat F Grondin L Costes P | | 0，，05： | 1 |
| 17 | Development of young pear trees and occurrence of first flowering:a varietal comparison显示文摘 | Costes E Belouin A Brouard L | 2004 | Journal of Horticultural Science&Biotechnology2004，79，1： | 1 |
| 18 | Radiofrequency is a safe and e- fective treatment of turbinate hypertrophy显示文摘 | Coste A Yona L Blumen M | 2001 | Laryngoscope2001，1，5： | 1 |
| 19 | Efficacy and tolerance of a new silicone stent for the treatment of benign tracheal stenosis显示文摘 | Costes F Polio J L | 2000 | Chest2000，118，2： | 1 |
| 20 | Subthalamic nucleus location: relationships between stereotactic AC-PE-based diagrams and MRI anatomy-based contours显示文摘 | Caire F Ouchchane L Coste J | 2009 | Stereotact Funct Neurosurg2009，87，6： | 1 |
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