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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Specific interaction of the first three zinc fingers of TF Ⅲ A with the internal control region of the Xenopus 5S RNA gene显示文摘 | LIAO X B CLEMENS K R TENNANT L | 1992 | J Mol Biol1992，223，4： | 1 |
| 3 | Relative contributions of the zinc fingers of transcription factor Ⅲ A to the energetics of DNA binding显示文摘 | CLEMENS K R ZHANG P LIAO X | 1994 | J Mol Biol1994，244，1： | 1 |
| 4 | Advanced navigation planning including soft tissue management显示文摘 | Clemens U Miehlke R K | 2005 | Orthopedics2005，28，10： | 1 |
| 5 | In and ex-situ investigations of theβ-phase in a Nb and Mo containing γ-TiAl based alloy显示文摘 | CLEMENS H CHLADIL H F WALLGRAM W ZICKLER G A GERLING R LISS K D KREMMER S GUTHER V SMARSLY W | | 0，，06： | 1 |
| 6 | Psychosocial health of living kidney donors : a systematic re-view显示文摘 | Clemens K K Thiessen-Philbrook H Parikh C R ei al | 2006 | Am J Transplant2006，6，12： | 1 |
| 7 | In situ high-energy X-ray diffraction study and quantitative phase analysis in theα+γphase field of titanium aluminides显示文摘 | Yeoh L A Liss K D Bartels A Chladil H Avdeev M Clemens H Gerling R Buslaps T | 2007 | Scripta Materialia2007，57，12： | 1 |
| 8 | Comparison of culture-dependent and independent techniques for characterisation of themicroflora of peroxyacetic acid treated,vacuum-packaged beef显示文摘 | Brightwell G Clemens R Adam K ef al | 2009 | Food Microbiology2009，26，3： | 1 |
| 9 | Dimerization of the human papillomavirus E7 oncoprotein in viv显示文摘 | Clemens K E Brent R Gyuris J | 1995 | Virology1995，214，1： | 1 |
| 10 | The transcriptomes of columnar and standard type apple trees ( Malus x domestica) - A compara- tive study 显示文摘 | Clemens K Romina P Erwin R | 2012 | Gene2012，2，： | 1 |
| 11 | Epithelial endoplasmicreticulum stress and apoptosis in sporadic idiopcathic pulmonaryfibrosis显示文摘 | Martina K Clemens R Poornima M | 2008 | Am J Respor Crit Care Med2008，178，： | 1 |
| 12 | Supplementation with antioxidants prior to bone marrow transplantation 显示文摘 | CLEMENS M R WALADKHANI A R BUBLITZ K | 1997 | Wien Klin Wochenschr1997，109，19： | 1 |
| 13 | Third-generation zotarolimus-eluting and everolimus-eluting stents in all-comer patients requiring a percutaneous coronary intervention (DUTCH PEERS): a randomised, single-blind, multicentre, non-inferiority trial显示文摘 | Clemens von Birgelen Hanim Sen Ming Kai Lam Peter W Danse Gillian A J Jessurun Raymond W M Hautvast Gert K van Houwelingen Alexander R Schramm R Melvyn Tjon Joe Gin Johannes W Louwerenburg Frits H A F de Man Martin G Stoel Marije M L?wik Gerard C M Linsse | 2013 | The Lancet2013，，： | 1 |
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