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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 3 | Antifungal evaluation of pseudolaric acid B, a major constituent of pseudolarix kaempferi显示文摘 | Li E Clark A M Hufford C D | 1995 | J Nat Prod1995，58，： | 1 |
| 4 | Identification of human brain tumour initiating ceils 显示文摘 | SINGH S K HAWKINS C CLARKE I D | 2004 | Nature2004，432，7015： | 1 |
| 5 | Using a cellular automaton model to forecast the effects of urban growth on habitat pattern in southern California显示文摘 | Syphard A D Clarke K C Franklin J | 2005 | Ecological Complexity2005，2，2： | 1 |
| 6 | Identification of human brain tumour initiating cells显示文摘 | SINGH S K HAWKINS C CLARKE I D | 2004 | Nature2004，432，7015： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | Generalized Predictive Control显示文摘 | Clarke D W Mohtadi C Tufts P S | 1987 | Automatic1987，23，2： | 1 |
| 9 | The split-cavity oscillator: a high-power e-beam modulator and microwave source显示文摘 | Marder B M Clark M C Bacon L D | 1992 | IEEE Trans on Plasma Science1992，20，3： | 1 |
| 10 | Micrometastases in esophagogastric cancer:high detection rate in resected rib segments显示文摘 | O'SULLIVAN G C SHEEHAN D CLARKE A | 1999 | Gastroenterology1999，116，3： | 1 |
| 11 | Pressure effects on intra- and intermolecular interations within proteins显示文摘 | Boonyaratanakornkit B B Park C B Clark D S | 2002 | Biochim Biophysic Acta (BBA) /Protein Structure Molecular Enzymol2002，1595，1： | 1 |
| 12 | Magnetically insulated transmission line oscillator显示文摘 | Clark M C Marder B M Bacon L D | 1988 | Appl Phys Lett1988，52，1： | 1 |
| 13 | Strategic Human Resource Practices,Top Management Team Social Networks,and Firm Performance:The Role of Human Resource Practices in Creating Organizational Competitive Advantage显示文摘 | Collins C J Clark K D | 2003 | Academy of Management Journal2003，46，6： | 1 |
| 14 | Effect of Transient Thermal Cycles in A Supercritical Water-Cooled Reactor on The Microstructure and Properties of Ferritic-Martensitic Steels显示文摘 | Totemeier T C Clark D E | | 0，，： | 1 |
| 15 | Spectral discrimination of coral mortality states following a severe bleaching event 显示文摘 | CLARK C D MUMBY P J CHISHOLM J R M | 2000 | International Journal of Remote Sensing2000，21，11： | 1 |
| 16 | Determination of width of meander-belt sandstone reservoirs from vertical downhole data,Mesaverde Group,Piceance Greek Basin,Colorado显示文摘 | LORENZ J C HEINZE D M CLARK J A | 1985 | AAPG Bulletin1985，69，5： | 1 |
| 17 | First-principles simulation: Ideas, illustrations and the CASTEP code 显示文摘 | SEGALL M D L1NDAN P J D PROBERT M J PICKARD C J HASNIP P J CLARK S J PAYNE M C | 2002 | Journal of Physics: Condensed Matter2002，14，11： | 1 |
| 18 | Certificate chain discovery in spki/sdsi显示文摘 | Clarke D Elien J E Ellison C | 2001 | Joumal of Computer Security2001，9，4： | 1 |
| 19 | Strategic human resource practices, top management team social networks, and firm performance: the role of human resource in creating organizational competitive advantage 显示文摘 | Collins C J Clark K D | 2003 | Academy of Management Journal2003，，6： | 1 |
| 20 | Generalized potential of adult neural stem cells 显示文摘 | Johansson C B | 2000 | Science2000，288，： | 1 |
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