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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 3 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 4 | Protective action of glutamine in rats with severe acute liver failure显示文摘BACKGROUND Severe acute liver failure(SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver function.Thioacetamide(TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2(Nrf2) activates the antioxidant protection of cells. Studies have evidenced the involvement of inflammatory mediators in conditions of oxidative stress.AIM To evaluate the antioxidant effects of glutamine on Nrf2 activation and NFκBmediated inflammation in rats with TAA-induced IHAG.METHODS Male Wistar rats(n = 28) were divided into four groups: control,control+glutamine, TAA, and TAA + glutamine. Two TAA doses(400 mg/kg)were administered intraperitoneally, 8 h apart. Glutamine(25 mg/kg) was administered at 30 min, 24 h, and 36 h. At 48 h, blood was collected for liver integrity analysis [aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP)]. The liver was harvested for histology and assessment of oxidative stress [thiobarbituric acid-reactive substances(TBARS), catalase(CAT), glutathione peroxidase(GPx), glutathione S-transferase(GST), glutathione(GSH), Nrf2, Kelch-like ECH-associated protein 1(Keap1),NADPH quinone oxidoreductase1(NQO1), superoxide dismutase(SOD)] and inflammatory process.RESULTS TAA caused disruption of the hepatic parenchyma, with inflammatoryinfiltration, massive necrosis, and ballooning degeneration. Glutamine mitigated this tissue damage, with visible regeneration of hepatic parenchyma; decreased TBARS(P < 0.001), GSH(P < 0.01), IL-1β, IL6, and TNFα levels(P <0.01) in hepatic tissue; and decreased blood levels of AST, ALT, and ALP(P <0.05). In addition, CAT, GPx, and GST activities were restored in the glutamine group(P<0.01, P <0.01, and P <0.001, respectively vs TAA alone). Glutamine increased expression of Nrf2(P < 0.05), NQO1, and SOD(P < 0.01), as well as levels of IL-10(P <0.001), while decreasing expression of Keap1, TLR4, NFκB(P < 0.001), COX-2 and iNOS,(P < 0.01), and reducing NO_2 and NO_3 levels(P < 0.05).CONCLUSION In the TAA experimental model of IHAG, glutamine activated the Nrf2 pathway,thus promoting antioxidant protection, and blunted the NFκB-mediated pathway, reducing inflammation. | Elizangela G Schemitt Renata M Hartmann Josieli R Colares Francielli Licks Jéferson O Salvi Cláudio A Marroni Norma P Marroni | 2019 | World Journal of Hepatology2019，11，3： | 5 |
| 5 | Radiative heat transfer and thermal characteristics of Fe-based oxides coated SiC and Alumina RPC structures as integrated solar thermochemical reactor显示文摘This paper investigated radiative heat transfer and thermal characteristics of Fe-based oxides coated SiC and Alumina reticulated porous ceramic structures as integrated solar thermochemical reactor.High-flux solar radiation absorption and axial temperature distribution in the ceramic foams reactor were analyzed by adopting surface-to-surface radiation model coupled to the P1approximation for radiation heat transfer.The radiative heat transfer and thermal characteristics of different foam-type RPC structures,including SiC,CeO_2,FeAl_2O_4,NiFeAlO_4,Fe_3O_4/SiC,and NiFe_2O_4/SiC were evaluated.The mass flow rate and foam structural parameters,including the permeability,pore mean cell size,and extinction coefficients have significantly affected the axial temperature distribution,pressure drop,heat transfer,and fluid flow.Integrated porous structure to the solar receiver could maximize the incorporation of redox powder in the reacting medium,lower the pressure drop,and enhance the thermal performance of the thermochemical reacting system.SiC structure was the candidate materials in the case where more heat flux and high axial temperature distribution is needed.However,Fe-based oxide coated Al_2O_3structure could be considered regarding the heat transfer enhancement along with the catalyst activity of oxygen carriers for solar thermochemical reacting system performance. | GUENE LOUGOU Bachirou SHUAI Yong PAN RuMing CHAFFA Gédéon AHOUANNOU Clément ZHANG Hao TAN HePing | 2018 | Science China(Technological Sciences)2018，61，12： | 2 |
| 6 | Regulation of migrating motor complexes by motilin and pancreatic polypeptide in human infants显示文摘 | Jadcheda SR Klee G Berseth CL | 1997 | Pediatr Res1997，42，3： | 1 |
| 7 | Design and synthesis of trans-N-cyclohex-yl]-4-quinolinecarboxamide(SB-277011):A potent and se-lective dopamine D3 receptor antagonist with high oral bi-oavailability and CNS penetration in the rat显示文摘 | Stemp G Ashmeade T Branch CL | 2000 | J Med Chem2000，43，9： | 1 |
| 8 | Amyloid plaque core protein in Alzheimer disease and Down syndrome显示文摘 | Masters CL Simms G Weinman NA Beyreuther K. | | 0，，： | 1 |
| 9 | Treatment of a-symptomatic vaginal candidiasis in pregnancy to prevent preterm birth:an openlabel pilot randomized controlled trial显示文摘 | Roberts CL Rickard K Kotsiou G | 2011 | BMC Pregnancy and Childbirth2011，11，11： | 1 |
| 10 | The short- and long-term outcomes of laparoscopic versus open surgery for colorectal cancer: a meta-analysis显示文摘 | Wang CL Qu G Xu HW | 2014 | Int J Colorectal Dis2014，29，3： | 1 |
| 11 | Otoplasty:anterior scraping technique and results in 500 cases显示文摘 | Louise CL Nicolas G Patrieia B | 2000 | Plast Reconstr Surg2000，105，： | 1 |
| 12 | Angiogenic gene therapy trial in patients with stable angina pectoris显示文摘 | Grines CL Watkins MW Helmer G | 2002 | Circulation2002，105，2： | 1 |
| 13 | Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C显示文摘 | Barr CL Wigg K Zai G | 2001 | Mol Psychiatry2001，6，3： | 1 |
| 14 | Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease 显示文摘 | Stahlschmidt J Varley CL Toogood G | 2005 | Kidney Int2005，68，3： | 1 |
| 15 | Induction of epigenetic altera-tions by dietary and other environmental factors显示文摘 | Mathers JC Strathdee G Relton CL | 2010 | Adv Genet2010，71，： | 1 |
| 16 | Phase I trial of a mel-anoma vaccine with gp100(280-288)peptide and tetanus helperpeptide in adjuvant:immunologic and clinical outcomes显示文摘 | Slingluff CL Jr Yamshchikov G Neese P | 2001 | ClinCancer Res2001，7，10： | 1 |
| 17 | Benzene and the hemopoietic stem cell显示文摘 | Morgan G J Mvares CL | 2005 | Chem Biol Interact2005，30，： | 1 |
| 18 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 19 | Total flavonoids of Herba Epimedii improves osteogenesis and inhibits osteoclastogenesis of human mesenchymal stem cells 显示文摘 | Zhang JF Li G Meng CL | 2009 | Pbytomedicine2009，16，67： | 1 |
| 20 | Characterization of plaque componetits with intravascular ultrasound elastography in human femoral and coronary arteries in vitro显示文摘 | De Korte CL Pasterkamp G van der Steen AF | 2000 | Circulation2000，102，6： | 1 |
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