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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | The Actin cross-linking domain of the Vibrio cholerae RTX toxin directly catalyzes the covalent cross-linking of actin显示文摘 | Christina L Cordero Dmitry S | 2006 | Biological Chemistry2006，281，32： | 1 |
| 3 | Gene expression analysis of toll - like receptor path- ways in heterophils from genetic chicken lines that dif- fer in their susceptibility to salmonella enteritidis 显示文摘 | MICHAEL H K HSIN I C CHRISTINA L S | 2012 | Front Genet2012，3，： | 1 |
| 4 | Physiology of resistant Deinococcus geothermalis bacterium aerobically cultivated in low-Manganese medium显示文摘 | Christina L Minna P J?rg B Peter N Mirja S S | 2012 | Journal of Bacteriology2012，194，6： | 1 |
| 5 | Multivariate mixing and mass balance (M3) calculations,a new tool for decoding hydro geochemical in formation显示文摘 | Marcus L Christina S Erik S | 1999 | Applied Geocheimstry1999，，14： | 1 |
| 6 | Compounding and molding of polyethylene composites reinforced with keratin feather fiber显示文摘 | Justin R B Walter F S Christina F E L | 2005 | Composites Science and Technology2005，65，： | 1 |
| 7 | Differential induction of nitric oxide,degranulation,and oxidative burst activities in response to microbial agunist stimulations in monocytes and heterophils from young commercial turkeys显示文摘 | Haiqi H Kenneth J G Christina L S | 2008 | Vet Immunol Immunop2008，123，34： | 1 |
| 8 | Transplam survivorship of bryophyte soil crusts in the Mojave Desert显示文摘 | CHRISTINA C LIOYD R S MARY L B | 2010 | Restoration Ecology2010，18，2： | 1 |
| 9 | Quantitative real-time PCR detection of toxic nodularia cyanobacteria in the Baltic Sea显示文摘 | Kerttu K Christina L Pirjo R W Jouni J Kaarina S | 2007 | Appl Environ Microbiol2007，73，： | 1 |
| 10 | A Typology of Organizational Membership: Understanding Different Membership Relationships Through the Lens of Social Exchange显示文摘 | Christina L Stamper Suzanne S Masterson Joshua Knapp | 2009 | Management and Organization Review2009，147，： | 1 |
| 11 | Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1,and jun B through activation of extra cell ular signal-regulated kinases 1 and 2 显示文摘 | Christina H Jinfang L Mary S | 1998 | J Biol Chem1998，273，31： | 1 |
| 12 | Intrinsic motivation and exercise adherence显示文摘 | RICHARD M CHRISTINA M F DEBORAH L S | 1997 | 1NT J Sport Psychol1997，28，4： | 1 |
| 13 | Optlrnlza tion of Community Health Center Locations and Service Offerings with Statistical need Estimation显示文摘 | Paul M G Christina R S Julie L S | 2008 | IIE Transactio ns2008，40，9： | 1 |
| 14 | Tolerability and efficacy of carvedilol in patients with New York Heart Association class IV heart failure显示文摘 | Peter S Macdonald Anne M Keogh Christina L Aboyoun Mayanna Lund Raul Amor Dermot J McCaffrey | 1999 | Journal of the American College of Cardiology1999，，： | 1 |
| 15 | Time-course ofattention bias for pain-related cues in chronic daily headachesufferers显示文摘 | Christina L Daniel E S Brendan P B | 2009 | European Journal of Pain2009，13，： | 1 |
| 16 | Force modeling for needle insertion into soft tissue 显示文摘 | Allison M O Christina S Mark D O L | 2004 | IEEE Transactions on Biomedical Engineering2004，，10： | 1 |
| 17 | Activation of a Renin-angiotensin System in Ischemic Cardiac Sympathetic Nerve Endings and its Association with Norepinephrine Release显示文摘 | Roberto L Randi B S Christina J M | 2002 | Internati Immunopharmacol2002，2，： | 1 |
| 18 | Trends in predicting and controlling ash vaporization in coal-fired utility boilers显示文摘 | ERIC G E ADEL F S CHRISTINA M L | 2001 | Fuel Processing Technology2001，71，： | 1 |
| 19 | Perceived Organizational Membership:An Aggregate Framework Representing the Employee-Organization Relationship显示文摘 | CHRISTINA L S | 2003 | Journal of Organizational Behavior2003，24，5： | 1 |
| 20 | Anomalous capacity and cycling stability of xLi2 MnO3 · (1-x)Li-MO2 electrodes (M= Mn, Ni, Co) in lithium batteries at 50℃显示文摘 | Johnson C S Naichao L Christina L | 2007 | Electrochemistry Communications2007，9，： | 1 |
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