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| 1 | Transrectal ultrasound and magnetic resonance imaging measurement of extramural tumor spread in rectal cancer显示文摘AIM:To evaluate the agreement between transrectal ultrasound(TRUS) and magnetic resonance imaging(MRI) in classification of ≥ T3 rectal tumors.METHODS:From January 2010 to January 2012,86 consecutive patients with ≥ T3 tumors were included in this study.The mean age of the patients was 66.4 years(range:26-91 years).The tumors were all ≥ T3 on TRUS.The sub-classification was defined by the penetration of the rectal wall:a:0 to 1 mm;b:1-5 mm;c:6-15;d:> 15 mm.Early tumors as ab(≤ 5 mm) and advanced tumors as cd(> 5 mm).All patients underwent TRUS using a 6.5 MHz transrectal transducer.The MRI was performed with a 1.5 T Philips unit.The TRUS findings were blinded to the radiologist performing the interpretation of the MRI images and measuring the depth of extramural tumor spread.RESULTS:TRUS found 51 patients to have an early ≥ T3 tumors and 35 to have an advanced tumor,whereas MRI categorized 48 as early ≥ T3 tumors and 38 as advanced tumors.No patients with tumors classified as advanced by TRUS were found to be early on MRI.The kappa value in classifying early versus advanced T3 rectal tumors was 0.93(95% CI:0.85-1.00).We found a kappa value of 0.74(95% CI:0.63-0.86) for the total sub-classification between the two methods.The mean maximal tumor outgrowth measured by TRUS,5.5 mm ± 5.63 mm and on MRI,6.3 mm ± 6.18 mm,P = 0.004.In 19 of the 86 patients the following CT scan or surgery revealed distant metastases;of the 51 patients in the ultrasound ab group three(5.9%) had metastases,whereas 16(45.7%) of 35 in the cd group harbored distant metastases,P = 0.00002.The odds ratio of having distant metastases in the ultrasound cd group compared to the ab group was 13.5(95% CI:3.5-51.6),P = 0.00002.The mean maximal ultrasound measured outgrowth was 4.3 mm(95% CI:3.2-5.5 mm) in patients without distant metastases,while the mean maximal outgrowth was 9.5 mm(95% CI:6.2-12.8 mm) in the patients with metastases,P = 0.00004.Using the MRI classification three(6.3%) of 48 in the MRI ab group had distant metastases,while 16(42.1%) of the 38 in the MRI cd group,P = 0.00004.The MRI odds ratio was 10.9(95% CI:2.9-41.4),P = 0.00008.The mean maximal MRI measured outgrowth was 4.9 mm(95% CI:3.7-6.1 mm) in patients without distant metastases,while the mean maximal outgrowth was 11.5 mm(95% CI:7.8-15.2 mm) in the patients with metastases,P = 0.000006.CONCLUSION:There is good agreement between TRUS and MRI in the pretreatment sub-classification of ≥ T3 tumors.Distant metastases are more frequent in the advanced group. | Sφren R Rafaelsen Chris Vagn-Hansen Torben Sφrensen John Plφen Anders Jakobsen | 2012 | World Journal of Gastroenterology2012，18，36： | 14 |
| 2 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 3 | Systematic review of periprosthetic tibia fracture after total knee arthroplasties显示文摘AIM: To investigate the known incidences, treatment options, and related outcomes of periprosthetic tibia fractures after total knee arthroplasty(TKA).METHODS: A literature search was done to identify studies that fit the inclusion criteria. The database search yielded 185 results, which were further reduced by the exclusion criteria to 13 papers, totaling 157 patients that met these criteria. Incidence rates of the different types of periprosthetic tibia fractures were determined and their treatments were subsequently analyzed based on the fracture's subclass, with patient outcomes being overall favorable.RESULTS: Of the 144 documented patients, 54(37.5%) had a subclass C fracture, which are frequently seen in revision arthroplasties or when using cement intraoperatively. The fractures of subclasses A and B occur postoperatively. There were 90 subclass A and B fractures with incidences of 18.75% and 43.75% respectively. When broken down by type, 62(55.36%) were type 1, 24(21.4%) were type 2, 24(21.4%) were type 3, and 2(1.8%) were type 4. Furthermore, from the studies that included origin of injury, the types were further classified as having non-traumatic or traumatic origins. Type 1 had 78%(40/51) non-traumatic origin and 22%(11/51) traumatic origin. Fifteen fractures were type 2, but 5 were falls and 1 through a motor vehicle accident, giving a trauma causation of 40%(6/15). Of the 24 type 3 fractures, 12 were falls and 2 vehicular accidents, leading to a trauma causation of 58%(14/24).CONCLUSION: Type 1 fractures were the most common. Subclass A was treated with locking plates, B required a revision TKA, and C was treated intraoperatively or nonoperatively. | Nabil A Ebraheim Joseph R Ray Meghan E Wandtke Grant S Buchanan Chris G Sanford Jiayong LiuZ | 2015 | World Journal of Orthopedics2015，6，8： | 4 |
| 4 | Cloning and transcriptional analysis of the Thermoanaerobacter ethanolicus strain 39E maltose ABC transport system显示文摘 | CHRIS R J MYRNA R HERBERT J S | 2002 | Extremophiles2002，6，4： | 1 |
| 5 | Applications of array biosensor for detection of food allergens显示文摘 | LISA C CHRIS R T LIGLER S | 2004 | Journal of AOAC International2004，87，6： | 1 |
| 6 | Influence of socio-economic and cultural factors in rice varietal diversity management on-farm in Nepal显示文摘 | RAM B R CHRIS G BHUWON S | 2007 | Agriculture and Human Values2007，24，： | 1 |
| 7 | Utility of Remote Sensing in Predicting Crop and Soil Characteristics 显示文摘 | Chris T L David R S Michael S C | 2003 | Precision Agrieuhure2003，4，： | 1 |
| 8 | Flavonoids and UV Photoprotection in Arabidopsis Mutants显示文摘 | Ken G R Ewald E S Chris W | 2015 | Zeitschrift für Naturforschung C2015，56，9： | 1 |
| 9 | Coherent Equalization and POLMUX-RZ- DQPSK for Robust 100-GE Transmission 显示文摘 | Fludger Chris R S Duthel Thomas Borne Dirk van den | 2008 | J of Lightwave Technology2008，26，1： | 1 |
| 10 | Slurry-Based semisolid die casting显示文摘 | CHRIS S R PATRICIO F M | 2001 | Advanced Materials & Process2001，，10： | 1 |
| 11 | The Adjustable Grooved Feed Extruder显示文摘 | Chris R Janusz S | 2000 | Plastics Additives & Compounding2000，2，6： | 1 |
| 12 | Coherent equalization and POLMUX-RZ-DQPSK for robust 100 GE transmission 显示文摘 | Chris R S Fludger Thomas Duthel Dirk van den Borne | 2008 | Journal of Lightwave Technology2008，26，1： | 1 |
| 13 | American Associa- tion of Neuroscience Nurses Scope and Standards of Prac- tice for Neuroscience Advanced Practice Nurses显示文摘 | Chris S A Nancy V Rossi S R | 2010 | J Neu- rosci Nurs2010，42，3： | 1 |
| 14 | Zebrafish heart regeneration occurs by cardiomyoeyte dedifferentiation and proliferation显示文摘 | Chris J Eduard S Marina R | 2013 | Na- flare2013，464，7288： | 1 |
| 15 | The BioGRID Interaction Database:2008 update显示文摘 | Chris S Bobby-Joe B Teresa R | 2008 | Nucleic Acids Research2008，36，： | 1 |
| 16 | Active control of broad structural vibration using the LMS adaptive algorithm显示文摘 | Jeffrey S V Ricardo A B Chris R F | 1993 | Journal of Sound and Vibration1993，166，2： | 1 |
| 17 | Switching in stock index and treasury futures returns and measures of stock market stress 显示文摘 | Nares B Robert A C Chris S R | 2010 | Future Market2010，30，8： | 1 |
| 18 | Objectively judging the quality of a protein structure from a Ramachandran plot显示文摘 | HOOFT R W W CHRIS S GERRIT V | 1997 | Bioinformatics1997，13，4： | 1 |
| 19 | The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes 显示文摘 | Liu S Liu Y Yang X Tong C Edwards D Parkin I A P Zhao M Ma J Yu J Huang S Wang X Wang J Lu K Fang Z Bancroft I Yang T J Hu Q Wang X Yue Z Li H Yang L Wu J Zhou Q Wang W King G J Chris Pires J Lu C Wu Z Sampath P Wang Z Guo H Pan S Yang L Min J Zhang D Jin D Li W Belcram H Tu J Guan M Qi C Du D Li J Jiang L Batley J Sharpe A G Park B S Ruperao P Cheng F Espinosa Waminal N Huang Y Dong C Wang L Li J Hu Z Zhuang M Huang Y Huang J Shi J Mei D Liu J Lee T Wang J Jin H Li Z Li X Zhang J Xiao L Zhou Y Liu Z Liu X Qin R Tang X Liu W Wang Y Zhang Y Lee J Kim H H Denoeud F Xu X Liang X Hua W Wang X Wang J Chalhoub B Paterson A H | 2014 | Nature Communications2014，5，： | 1 |
| 20 | Water organization and molecular mobility in maize starch investigate by two-dimensional solid-state NMR显示文摘 | Chris de Costa J R Haverkamp J | 1994 | J Agric Food Chem1994，42，： | 1 |
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