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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Estimating liver weight of adults by body weight and gender显示文摘瞄准:为了为估计接枝的足够估计标准肝重量,为癌症在主要肝切除术在实时施主肝移植和残余肝缩放。方法:在这研究,体重和身高的人体测量的数据在 159 个实时的肝施主为与肝重量的关联被测试包括中间的肝的静脉经历了施主权利肝切除术。肝重量从在背表格获得的正确脑叶接枝重量被计算,在计算断层摄影术上由正确脑叶的比例划分了。结果:这些题目,所有汉语,有 35.8+/-10.5 年,和女性的吝啬的年龄到 118:41 的男比率。正确脑叶的吝啬的体积是 710.14+/-131.46 mL 并且在计算断层摄影术上占据了整个肝的 64.55%+/-4.47% 。正确脑叶称了 598.90+/-117.39 g,估计的肝重量是 927.54+/-168.78 g。当体重和身高受到多重逐步的线性回归分析时,身高被发现不足道。一样的体重的女性有稍微更低的肝重量。一个公式基于体重和性被导出:估计的标准肝重量(g)= 218 + BW (kg ) x 12.3 + 性 x 51 (R2 = 0.48 )( 女 = 0,男 = 1 ) 。基于这 159 个题目,的人体测量的数据肝重量用在白种人,日语,朝鲜语,和汉语上从研究导出的以前出版的公式被计算。所有公式与这个公式相比过高估计肝重量。日本公式为成年人过高估计估计的标准肝重量(ESLW ) 不到 60 kg。结论:对中国男性和女性适用的一个公式是可得到的。为单个赛跑的一个公式显得必要。 | See Ching Chan Chi Leung Liu Chung Mau Lo Banny K Lam Evelyn W Lee Yik Wong Sheung Tat Fan | 2006 | World Journal of Gastroenterology2006，12，14： | 22 |
| 3 | Modulation of graft vascular inflow guided by flowmetry and manometry in liver transplantation显示文摘BACKGROUND:Survival of the partial graft after living donor liver transplantation owes much to its tremendous regenerative ability.With excellent venous outflow capacity,a graft within a wide range of graft-to-standard-liver-volume ratios can cope with portal hypertension that is common in liver transplant recipients.However,when the ratio range is exceeded,modulation of graft vascular inflow becomes necessary for graft survival.The interplay between graft-to-standard-liver-volume ratio and portal pressure,in the presence of portosystemic shunt or otherwise,requires individualized modulation of graft portal and arterial inflows.Boosting of portal inflow by shunt ligation can be guided by transonic flowmetry,whereas muting of portal inflow by splenic artery ligation can be monitored by portal electronic manometry.METHOD:We describe four cases to illustrate the above.RESULTS:One patient had hepatic artery thrombosis resulting from splenic artery steal syndrome which was the sequela of small-for-size syndrome.Emergency splenic artery ligation and re-anastomosis of the hepatic artery successfully muted the portal inflow and boosted the hepatic arterial inflow.Another patient with portal vein thrombosis underwent thrombendvenectomy.Portal inflow was boosted with ligation of portosystemic shunt,which is often present in these patients with portal hypertension.The coexistence of splenic aneurysm and splenorenal shunt required ligation of both in the third patient.The fourth patient,with portal pressure and flow monitoring,avoided ligation of a coronary vein which became a main portal inflow after portal thrombendvenectomy.CONCLUSION:Management of graft inflow modulation guided selectively by transonic flowmetry or portal manometry was described. | See Ching Chan Chung Mau Lo Kenneth SH Chok William W Sharr Tan To Cheung Simon HY Tsang Albert CY Chan Sheung Tat Fan | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，6： | 5 |
| 4 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 5 | High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation显示文摘The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later. | Tan To Cheung Kenneth SH Chok Regina CL Lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 3 |
| 6 | Retrohepatic vena cava deroofing in living donor liver transplantation for caudate hepatocellular carcinoma显示文摘The removal of tumor together with the native liver in living donor liver transplantation for hepatocellular carcinoma is challenged by a very close resection margin if the tumor abuts the inferior vena cava.This is in contrast to typical deceased donor liver transplantation where the entire retrohepatic inferior vena cava is included in total hepatectomy.Here we report a case of deroofing the retrohepatic vena cava in living donor liver transplantation for caudate hepatocellular carcinoma.In order to ensure clear resection margins,the anterior portion of the inferior vena cava was included.The right liver graft was inset into a Dacron vascular graft on the back table and the composite graft was then implanted to the recipient inferior vena cava.Using this technique,we observed the no-touch technique in tumor removal,hence minimizing the chance of positive resection margin as well as the chance of shedding of tumor cells during manipulation in operation. | See Ching Chan William W Sharr Tan To Cheung Albert CY Chan Simon HY Tsang Kenneth SH Chok Kin Chung Leung Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 2 |
| 7 | Interesting physical properties of the new spinel phase of Si《,3》N《,4》 and C《,3》N《,4》显示文摘 | Ouyang L Z and Ching W Y | 1999 | Physical Review Letters1999，83，： | 1 |
| 8 | Demonstration of receptor binding properties of VP2 of very virulent strain infectious bursal disease virus on Veto cells显示文摘 | Chi W Y Yin S Y Ching M M | 2007 | Virus Res2007，123，1： | 1 |
| 9 | miR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling 显示文摘 | WONG Q W CHING A K CHAN A W | 2010 | Clin Cancer Res2010，16，3： | 1 |
| 10 | Higher-order multivariate Markov chains and their applications显示文摘 | Ching W K Ng M K Fung E S | 2008 | Linear Algebra and its Applications2008，428，2： | 1 |
| 11 | Factorized banded inverse preconditioners for matrices with Toeplitz structure 显示文摘 | Lin F R Ng M K Ching W K | 2005 | Siam Journal on Scientific Computing2005，26，6： | 1 |
| 12 | Theoretical prediction of the structure and properties of cubic spinel nitrides显示文摘 | Mo S D Ouyang L Z | 2002 | Journal of the American Ceramic Society2002，85，： | 1 |
| 13 | Theoretical Construction of the Magnetic Hamiltonian and Zero-temperature Anisotropie Energy in Nd2FetaB 显示文摘 | ZHONG Xuefu CHING W Y | 1989 | Phys Rev B1989，40，： | 1 |
| 14 | Electronic and optrcal properties of three phases of titanium dioxide: futile anatase and brookite 显示文摘 | MO SHANG DI CHING W Y | 1995 | Phys Rev B1995，51，13： | 1 |
| 15 | Solar photocatalytic degradation of gaseous formaldehyde by sol-gel TiO2 thin fihn for enhancement of indoor air quality显示文摘 | Ching W H Leung Michael Leung Dennis Y C | 2004 | Solar Energy2004，77，2： | 1 |
| 16 | Imerphase precipltadon of nanometer-sized carbides in a titanium molybdenum bearing low carbon steel显示文摘 | Hung W Y Po Y C Ching Y H e* al | 2011 | Acta Materialia2011，59，： | 1 |
| 17 | Enhanced activity and enantioselectivity of Candida rugosa lipase immobilized on maeroporous adsorptive resins for ibuprofen resolution显示文摘 | Yu H W Wu J C Ching C B | 2004 | Biotechnol Lett2004，26，8： | 1 |
| 18 | Interesting physical properties of the new spinel phase of Si3 N4 and C3N4显示文摘 | MO S D OUYANG L CHING W Y | 1999 | Phys Rev Lett1999，83，24： | 1 |
| 19 | Detection of machine failure:hidden Markov model approach显示文摘 | TAI A H CHING W K CHAN L Y | 2009 | Computers and Industrial Engineering2009，57，2： | 1 |
| 20 | Higher-order multivariate Markov chains and their applications显示文摘 | Ching W K Ng M K Fung E S | 2008 | Linear Algebra and its Applica- tions2008，428，2： | 1 |
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