| 12 | Biomaterial-assisted photoimmunotherapy for synergistic suppression of cancer progression显示文摘Photoimmunotherapy is an emerging treatment modality that uses photothermal,photodynamic and photochemical processes to fight against cancer by eliciting a robust host immune response.Recently,various nanoformulations of biomaterials have been rationally designed as highly effective photosensitive agents,immunoadjuvants or carriers to enhance phototherapeutic efficacy,boost immune stimulation,amplify nano-permeability and monitor cancer progression in situ.Nevertheless,relying solely on a single-modality therapy may not completely ablate primary tumors,and the metastasis and recurrence of tumors remain a serious challenge.To solve this issue,the strategy of combining photoimmunotherapy with other immunotherapies,such as immune checkpoint blockade,chimeric antigen receptor-T cell or cytokine therapy,can greatly enhance the effectiveness of oncology treatment and reduce the traditional adverse effects.Thus,it is very valuable to summarize the research progress in biomaterial-assisted combination photoimmunotherapy for clinical translation.In this review,the recent advances in constructing multifunctional nano-biomaterials for combinatorial photoimmunotherapy of cancer are summarized.Furthermore,the opportunities,challenges,future trends and prospects in this field are also analyzed to pave the way for advancing the next generation of clinical cancer management strategies. | Yanan Li Jing Cui Chenlong Li Caiting Deng Guowei Deng Hui Zhang Feifei An | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
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