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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016,3,1: | 3 |
| 2 | Lactic acid bacteria as pro-technological,bioprotective and health-promoting cultures in the dairy food industry显示文摘Lactic acid bacteria (LAB) constitute pivotal microorganisms for the food industry due to their considerable technological and functional potential.Fermented dairy products,that is ancient traditions worldwide,still have been accepted and consumed today for their nutritional and organoleptic attributes.In accordance with the current trends in the market and greater awareness of consumer well-being,a detailed assessment of the health effects of dairy product consumption has been undertaken with particular reference to the production of bioactive metabolites including i.e.,γ-aminobutyric acid,conjugated linoleic acid,bioactive peptides,exopolysaccharides as well as vitamins during LAB fermentation.The long histories of yogurt,kefir,and traditional fermented milk drink as sources of some certain probiotic bacteria as well as the opportunity to bio-fortify the matrix with bioactive microbial compounds in situ make fermented dairy products an attractive model in the efforts to develop sustainable functional food systems.Therefore,this review provides the main biochemical characteristics and biotechnological application of LAB as pro-technological,bioprotective,and health-promoting in the food chain. | Duygu Ağagündüz Teslime Özge Şahin Şerife Ayten Birsen Yılmaz Bartu Eren Güneşliol Pasquale Russo Giuseppe Spano Fatih Özogul | 2022 | Food Bioscience2022,47,3: | 2 |
| 3 | Continuous quality and shelf life monitoring of retail-packed fresh cod loins in comparison with conventional methods显示文摘 | Nga T.T. Mai María Gudjónsdóttir Hélène L. Lauzon Kolbrún Sveinsdóttir Emilía Martinsdóttir Hubert Audorff Werner Reichstein Dietrich Haarer Sigurdur G. Bogason Sigurjón Arason | 2010 | Food Control2010,,6: | 2 |
| 4 | Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95)显示文摘 | Christian A Anne Caillot A Marie-Héléne L P | 1998 | Clinical Chemistry1998,44,3: | 2 |
| 5 | SSJD15011600007878显示文摘 | María A. Mejía-Benítez Amélie Bonnefond Lo?c Yengo Marlène Huyvaert Aurélie Dechaume Jesús Peralta-Romero Miguel Klünder-Klünder Jaime García Mena Julia S. El-Sayed Moustafa Mario Falchi Miguel Cruz Philippe Froguel | 2015 | Diabetologia2015,,2: | 2 |
| 6 | Diagnostic uyility of cytokeratin 19 expression in multinodulal goiter with papillary areas and papillary carcinoma of thyroid显示文摘 | Erkilic S Aydin A Kocer NE | 2002 | Endocr Pathol2002,13,3: | 1 |
| 7 | Azithromycin for the secondary prevention of coronary heart disease events:The WIZARD study:a randomized controlled trial显示文摘 | O'Con nor CM Dun ne M W Pfeffer M A | | 0,,: | 1 |
| 8 | The lymphangiogenic vascular endothelial growth factors VEGF -C and -D are ligands for the integrin alpha9beta11显示文摘 | Vlahakis NE Young BA Atakilit A | 2005 | J Bioi Chern2005,280,6: | 1 |
| 9 | Activation of the Raf-MEK-ERK pathway iS r~quired for neutrophil extracellular trap formation 显示文摘 | Hakkim A Fuchs TA Martinez NE | 2011 | Nat Chem Biol2011,7,2: | 1 |
| 10 | Peroxisome proliferator-activated receptor gamma contributes to T lymphocyte apoptosis during sepsis显示文摘 | Soller M Tautenhahn A Brüne B | 2006 | Leukocyte Biol2006,79,1: | 1 |
| 11 | A randomized comparison of off-pump and on-pump multivessel coronary-artery bypass surgery显示文摘 | Khan NE De Souza A Mister R | 2004 | N Engl J Med2004,350,1: | 1 |
| 12 | MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression显示文摘 | Devy L Hajitou A | 2002 | FASEB J2002,16,6: | 1 |
| 13 | Physical activity and the risk of dementia in oldest old 显示文摘 | Sumic A Michael YL Carlson NE | 2007 | J Aging Health2007,19,2: | 1 |
| 14 | Bone sialoprotein mediates human endothelial cell attachment and migration and promotes angiogenesis显示文摘 | Bellahcène A Bonjean K Fohr B | 2000 | Circ Res2000,86,8: | 1 |
| 15 | High-frequency sensorineural hearing loss in patients with ankylosing spondylitis:is it an extrarticuler feature of disease显示文摘 | Mehmet A Alper NE Didem A | | 0,,: | 1 |
| 16 | An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules显示文摘 | Basu A Bodycombe NE Cheah JH | 2013 | Cell2013,154,5: | 1 |
| 17 | Epidemiology and outcome of severe pneumococcal pneumonia admitted to intensive care unit:a multicenter study显示文摘 | Mongardon N Max A BougléA Pène F | 2012 | Crit Care2012,16,4: | 1 |
| 18 | Olde B Free fatty acid receptor 1 (FFA(1)R/ GPR40) and its involvement in fatty-acid-stimulated insulin secretion显示文摘 | Salehi A Flodgren E Nilsson NE | 2005 | Cell Tissue Res2005,322,: | 1 |
| 19 | Regulation of muhidrug resistance 1 ( MDR1 ) P-glycoprotein gene expression and activity by heat-shock transcription factor 1 (HSF1) 显示文摘 | Vilaboa NE Galan A Troyano A | 2000 | J Biol Chem2000,275,24: | 1 |
| 20 | Quadrivalent meningococcal conjugate vaccines 显示文摘 | Pace D Pollard A J Messonier NE | 2009 | Vaccine2009,27,2: | 1 |