|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Knowledge Creation and Absorptive Capacity= The Effect of Intra-Distriet Shared Competences 显示文摘 | CESAR C BEATRIZ F | 2011 | Scandinavian Journal o{ Management2011，27，1： | 1 |
| 3 | Cardiopulmonary responses to exercise in patients of different age group with conges tive heart failure显示文摘 | Cesar Mde C Montesano F T Diniz R V | 2006 | Arq Bras Cardiol2006，86，1： | 1 |
| 4 | Docking and quantum mechanic studies on chlolinesterases and their inhibitiors 显示文摘 | Jose C B Cesar F S Jesus M C | 2007 | Eur J Medicinal Chem2007，42，1： | 1 |
| 5 | Endoscopic management of laryngo-tracheobronchial amyloidosis:a series of 32 patients 显示文摘 | Cesare P Serglo C Plero F | 2003 | Eur Arch Otorhinolaryogol2003，260，： | 1 |
| 6 | Knowledge absorptive capacity: new insights for its conceptualization and measurement 显示文摘 | CESAR C BEATRIZ F | 2010 | Journal of Business Research2010，63，： | 1 |
| 7 | Adaptive Genetic Algo- rithms for Dynamic Channel Assignment in Mobile Cellular Communication Systerns显示文摘 | Lima M A C Araujo A F R Cesar A C | 2007 | IEEE Transactions on Vehicular Technolgoy2007，56，5： | 1 |
| 8 | Knowledge Creation and Absorptive Capacity: the Effect of Intra-District Shared Cometences显示文摘 | Cesar C Beatriz F | 2011 | Scandinavian Journal of Management2011，27，1： | 1 |
| 9 | A Hybrid Methodology for Synthesis of Petri Net Models for Manufacturing Systems 显示文摘 | F D Cesare A Desrochers | 1992 | IEEE Trans Robot Automation1992，8，3： | 1 |
| 10 | Serum interleukin-6 as a marker of periprosthetie infection following total hip and knee arthroplasty显示文摘 | Di Cesare P E Chang E Preston C F | 2005 | J Bone Joint Surg Am2005，87，9： | 1 |
| 11 | C-JUN and CPP32 (CASPASE3)in human pancreatic cancer relation to cell proliferation and death显示文摘 | Meggiato T Calabrese F De Cesare C M | 2003 | Pancreas2003，26，1： | 1 |
| 12 | A rapid HPLCESI-MS/MS method for determination of dihydrouracil/uracil ratio in plasma:evaluation of toxicity to 5-flurouracil in patients with gastrointestinal cancer显示文摘 | Cesar I C Cunha-Junior G F Duarte Byrro R M | 2012 | Ther Drug Monit2012，34，1： | 1 |
| 13 | Over expression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E2-de- pendent plaque instability 显示文摘 | Cipollone F Prontem C Pini B Marini M Fazia M De Cesare D | 2001 | Circulation2001，104，8： | 1 |
| 14 | Isolation of amniotic stem cell lines with potential for therapy 显示文摘 | Paolo D C Georg B Minhaj S Tao X Cesar C S Laura P Gustavo M Angeline C S Evan Y S James J Y Mark E F Shay S and Anthony A | 2007 | Nature Biotectmology2007，25，1： | 1 |
| 15 | Spontaneous het- erotopic Pregnancy simultaneous ovarian,and intrauterine:a case report显示文摘 | Basile F Di Cesare C Quagliozzi L | 2012 | Case Rep Obstet gynecol2012，10，1： | 1 |
| 16 | Changes in the chemical composition of basil caused by different drying procedures显示文摘 | Di CESARE L F FORNI E VISCARDI D NANI R C | 2003 | Journal of Agricultural and Food Chemistery2003，51，12： | 1 |
| 17 | Meplazumab in hospitalized adults with severe COVID-19(DEFLECT):a multicenter,seamless phase 2/3,randomized,third-party double-blind clinical trial显示文摘Meplazumab,a humanized CD147 antibody,has shown favourable safety and efficacy in our previous clinical studies.In DEFLECT(NCT04586153),167 patients with severe COVID-19 were enroled and randomized to receive three dosages of meplazumab and a placebo.Meplazumab at 0.12 mg/kg,compared to the placebo group,showed clinical benefits in significantly reducing mortality by 83.6%(2.4%vs.14.6%,p=0.0150),increasing the proportion of patients alive and discharged without supplemental oxygen(82.9%vs.70.7%,p=0.0337)and increasing the proportion of patients who achieved sustained clinical improvement(41.5%vs.31.7%).The response rate in the 0.2 mg/kg group was relatively increased by 16.0%compared with the placebo group(53.7%vs.46.3%).Meplazumab also reduced the viral loads and multiple cytokine levels.Compare with the placebo group,the 0.3 mg/kg significantly increased the virus negative rate by 40.6%(p=0.0363)and reduced IL-8 level(p=0.0460);the 0.2 mg/kg increased the negative conversion rate by 36.9%,and reduced IL-4(p=0.0365)and IL-8 levels(p=0.0484).In this study,the adverse events occurred at a comparable rate across the four groups,with no unexpected safety findings observed.In conclusion,meplazumab promoted COVID-19 convalescence and reduced mortality,viral load,and cytokine levels in severe COVID-19 population with good safety profile. | Huijie Bian Liang Chen Zhao-Hui Zheng Xiu-Xuan Sun Jie-Jie Geng Ruo Chen Ke Wang Xu Yang Shi-Rui Chen Si-Yu Chen Rong-Hua Xie Kui Zhang Jin-Lin Miao Jun-Feng Jia Hao Tang Shuang-Shuang Liu Hong-Wei Shi Yong Yang Xiao-Chun Chen Vinay Malhotra Nosheen Nasir Iffat Khanum Faisal Mahmood Saeed Hamid Claudio Marcel Berdun Stadnik Kengi Itinose Caroline Cândida Carvalho de Oliveira Cesar Dusilek Lucas Rivabem Adilson Joaquim Westheimer Cavalcante Suzara Souto Lopes Wladmir Faustino Saporito Fábio JoséConcilio Fucci Jesus Abraham Simon-Campos Ling Wang Lin-Na Liu Qing-Yi Wang Ding Wei Zheng Zhang Zhi-Nan Chen Ping Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 1 |
| 18 | Adaptive Genetic Algorithmsfor Dynamic Channel Assignment in Mobile Cellular CommunicationSystems显示文摘 | Lima M A C Araujo A F R CeSar A C | 2007 | Vehicular Technology IEEE Transactions on2007，56，5： | 1 |
| 19 | Automated selection of test frequencies for fault diagnosis in analog electronic circuits显示文摘 | CESARE A MARCANTONIO C ADA F | 2005 | IEEE Transactions on Instrumenta- tion and Measurement2005，54，3： | 1 |
| 20 | Waveguide produced by fiber on glass method using Er3+-doped tellurite glass 显示文摘 | RIVERA V A - RODRIGUEZ E CHILLCCE E F CESAR C L BARBOSA L C | 2007 | Journal of Non℃rystalline Solids2007，353，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员