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| 1 | 直肠神经内分泌肿瘤的超声内镜表现及其临床价值:病例分析(英文)显示文摘随着内镜技术的提高,直肠神经内分泌肿瘤(NEN)检出率逐年提高。目前关于直肠NEN的研究比较有限,尤其在我国。本文回顾性收集2007年至2014年在浙一医院就诊,病理确诊为直肠NENs的患者的临床信息、普通肠镜及超声内镜(EUS)的镜下表现、病理等方面资料,并进行对比分析。本文显示直肠NEN的EUS镜下表现主要为边界清晰,回声均匀,NEN位于粘膜层或粘膜下层,且多为等回声或高回声。此外,EUS对直肠NEN的诊断具有较显著的临床价值。 | Qing GU Yi-ming LIN Li CEN Min XU Hong-zhang LI Xian-chu LIN Chao LU | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，10： | 2 |
| 2 | Transportation Characteristics Change under Rapid Urban Expansion:A Case Study of Shanghai显示文摘This paper focuses on the economic development and urban morphology as well as its impact on the transportation system during the urban expansion of Shanghai in the last more than 20 years(1986-2008).Based on data from 3 comprehensive transport surveys of Shanghai since 1986,the changes in residential trip demand,vehicle use,and the spatial distribution of trips were studied to understand the demands on the transportation system.The factors contributing to those changes in transportation demand were discussed,by which the conclusions were arrived:1) economic development promotes population growth and stimulates residential trip demand greatly;2) unsynchronized migration of population and job from central district to periphery district of Shanghai make trips and congestion diffuse in the same way;and 3) urban sprawl from a city center encourages the single-occupant vehicle mode,which imposes greater pressure on the roadway system.It is concluded that urban development should coordinate with the transportation system planning and expansion. | LI Ye YE Jianhong CHEN Xiaohong Mohamed A ABDEL-ATY P E CEN Min | 2010 | Chinese Geographical Science2010，20，6： | 2 |
| 3 | Theoretical and Experimental Study of Constant Restrictor Deep/ Shallow Pockets Hydrostatic/Hydrodynamic Conical Bearing显示文摘 | GUO Hong LAI Xin - min CEN Shao - qi | 2009 | ASME Journal of Tribology2009，131，4： | 1 |
| 4 | Predictive analysis on electric-power supply and demand in China 显示文摘 | HUANG Min HE Yong CEN Hai-yan | 2007 | Renewable Energy2007，32，7： | 1 |
| 5 | mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1–GluA2 interaction in the nucleus accumbens显示文摘Behavioral sensitization is a progressive increase in locomotor or stereotypic behaviours in response to drugs. It is believed to contribute to the reinforcing properties of drugs and to play an important role in relapse after cessation of drug abuse. However, the mechanism underlying this behaviour remains poorly understood. In this study, we showed that mTOR signaling was activated during the expression of behavioral sensitization to cocaine and that intraperitoneal or intra-nucleus accumbens (NAc) treatment with rapamycin, a specific mTOR inhibitor, attenuated cocaine-induced behavioural sensitization. Cocaine significantly modified brain lipid profiles in the NAc of cocaine-sensitized mice and markedly elevated the levels of phosphatidylinositol-4-monophosphates (PIPs), including PIP, PIP2, and PIP3. The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine. An RNA-sequencing analysis of the downstream effectors of mTOR signalling revealed that cocaine significantly decreased the expression of SynDIG1, a known substrate of mTOR signalling, and decreased the surface expression of GluA2. In contrast, AAV-mediated SynDIG1 overexpression in NAc attenuated intracellular GluA2 internalization by promoting the SynDIG1–GluA2 interaction, thus maintaining GluA2 surface expression and repressing cocaine-induced behaviours. In conclusion, NAc SynDIG1 may play a negative regulatory role in cocaine-induced behavioural sensitization by regulating synaptic surface expression of GluA2. | Hong-chun Li Jia-mei Zhang Rui Xu Yong-hai Wang Wei Xu Rong Chen Xue-mei Wan Hao-luo Zhang Liang Wang Xiao-jie Wang Lin-hong Jiang Bin Liu Ying Zhao Yuan-yuan Chen Yan-ping Dai Min Li Hua-qin Zhang Zhen Yang Lin Bai Jie Zhang Hong-bo Wang Jing-wei Tian Ying-lan Zhao Xiao-bo Cen | 2022 | Acta Pharmacologica Sinica2022，43，2： | 1 |
| 6 | A Weighting Window Applied to the Digital Image Correlation Method显示文摘 | Wang Min Cen Yuwan Hu Xiaofang | 2009 | Optics Laser Technology2009，41，： | 1 |
| 7 | P53 deletion is independently associated with increased age and decreased survival in a cohort of Chinese patients with diffuse large B-cell lymphoma显示文摘 | Zhuxia Jia Jinyuan He Ling Cen Wenmin Han Naike Jiang Jianhe Yang Min Zhou | 2012 | Leukemia & Lymphoma2012，，11： | 1 |
| 8 | Circulating tumor cells in the diagnosis and management of pancreatic cancer显示文摘 | Putao Cen Xiaoling Ni Jingxuan Yang David Y. Graham Min Li | 2012 | BBA - Reviews on Cancer2012，，2： | 1 |
| 9 | Warming with an underbody warming system reduces intraoperative hypothermia in patients undergoing laparoscopic gastrointestinal surgery: A randomized controlled study显示文摘 | Ying Pu Gang Cen Jing Sun Jin Gong Ying Zhang Min Zhang Xia Wu Junjie Zhang Zhengjun Qiu Fang Fang | 2013 | International Journal of Nursing Studies2013，，： | 1 |
| 10 | A weighting window applied to the digital image correlation method显示文摘 | WANG Min CEN Yu-wan | 2009 | Optics and Laser Technology2009，41，2： | 1 |
| 11 | A weighting window applied to the digital correlation method显示文摘 | Wang Min Cen Yuwan | 2009 | Optic and Laser Technology2009，41，2： | 1 |
| 12 | Measurement of Soluble Solids Contents and PH in Orange Juice Using Chemometries and Vis-NIRS显示文摘 | CEN Haiyan HE Yong HUANG Min | 2006 | Journal of Agricultural and Food Chemistry2006，54，74： | 1 |
| 13 | Combination and comparison of multivariate analysis for the identification of orange varieties using visible and near infrared reflectance spectroscopy显示文摘 | Cen Haiyan He Yong Huang Min | 2007 | European Food Research and Technology2007，225，56： | 1 |
| 14 | Combination and comparison of multivariate analysis for the identification of orange varieties using visible and near infrared reflectance spectroscopy显示文摘 | Cen Haiyan He Yong Huang Min | 2007 | European Food Research and Technology2007，225，56： | 1 |
| 15 | Measurement of Soluble Solids Contents and pH in Orange Juice Using Chemometrics and Vis-NIRS 显示文摘 | CEN Hai-yan HE Yong HUANG Min | 2006 | Journal of Agricultural and Food Chemistry2006，54，20： | 1 |
| 16 | Association of Thyroid Nodules with Various Elements in Urine and Blood Serum: A Case-Control Study显示文摘Thyroid nodules are a common clinical problem caused by various factors,including environmental and nutritional factors and genetic background.The environment can modulate and influence not only the risk of thyroid nodules but also the severity of disease in humans[1].The environment is awash with elements,and all mineral elements,including heavy metals and trace elements,are considered potentially toxic.A significantly higher incidence of thyroid cancer has been reported in populations exposed to low doses of metallic elements in volcanic areas over a long period[2].As research on thyroid disorders continues,it is becoming clear that abnormalities in trace elements in the body can affect the development of thyroid-related disorders. | LI Xiang Zhi WU Cai Lian CEN Li Ting HUANG Ming Le HUANG Min Min QIU Mei Ting LU Xiao Ling | 2024 | Biomedical and Environmental Sciences2024，37，3： | 0 |
| 17 | Purification and properties of alkaline phosphatase of silkworm Bombyx mori显示文摘Alkaline phosphatase(AKP),from the succus entericus of silkworm,was purified using 10%-50%ammonium sulfate fractions,ion exchange chromatography of DEAE-Sepharose,and size exclusion chromatography of Sephacryl S-200.The purification fold was 464 times and specified activity was 3936 U/mg.Optimum pH value of the phosphatase was 10.5,and was stable between pH 7.5 and 11.The optimum temperature of the phosphatase was 40℃ and it was unstable over 50℃.Km value of the phosphatase was 1.25 mmol/L.In a given condition,the phosphatase was selectively modified by PCMB,NBS,PMSF,TNBS,SUAN,DTT,BrAc,and IAc,the results indicate that PMSF,SUA,BrAc,IAc,and TNBS could obviously inhibit the activity of the phosphatase,and the degree of inhibition depended on the concentration of these reagents.There was little effect on the activity of phosphatase after treatment by PMSF,DTT,and NBT.We primarily conclude that mercapto and imidazole are essential for AKP from silkworm.Also,Lys residue and disulfide bands are necessary to protect the catalysis of the AKP. | TANG Yunming CEN Liang CHU Bo LI Changchun XU Min LUO Ying LU Cheng | 2006 | Frontiers in Biology2006，1，3： | 0 |
| 18 | 肝癌细胞模型库及其药物基因组学“蓝图”显示文摘文章简介原发性肝癌异质性显著,耐药性突出,预后不良。不同国家地区之间肝癌致病因素差异明显,对肝癌的精准治疗带来严重挑战。全球每年超过50%的新增病例和死亡病例均发生在中国。由大量细胞系构成的细胞系平台在乳腺癌、肺癌等癌症研究中证明细胞系平台能够模拟癌症的遗传异质性和药物响应,通过细胞系平台可以发现与药物敏感性相关的分子标志物。 | 邱志欣 李虹 章正涛 Zhenfeng Zhu Sheng He Xujun Wang Pengcheng Wang Jianjie Qin Liping Zhuang Wei Wang Fubo Xie Ying Gu Keke Zou Chao Li Chun Li Chenhua Wang Jin Cen Xiaotao Chen Yajing Shu Zhao Zhang Lulu Sun Lihua Min Yong Fu Xiaowu Huang Hui Lv He Zhou Yuan Ji Zhigang Zhang Zhiqiang Meng 施晓雷 张海斌 李亦学 惠利健 | 2020 | 科学新闻2020，，2： | 0 |
| 19 | Characterizing the Molecular Abnormalities in Rare De Novo Ph^+ Acute Myeloid Leukemia显示文摘 | Hong-Ying Chao Guang-Ying Sheng Xiu-Wen Zhang Min Zhou Hong-Jie Shen Su-Ning Chen Jian-Nong Cen Yi-Wu Sun Tao Chen Xu-Zhang Lu Ri Zhang | 2018 | Chinese Medical Journal2018，，10： | 0 |
| 20 | Sources and conservative mixing of uranium in the Taiwan Strait显示文摘Seawater samples are collected in the spring of 2013 from the Taiwan Strait for the analysis of uranium(U)concentrations and isotopic compositions using MC-ICP-MS, and the geochemical behavior patterns of U in the Taiwan Strait are then investigated. Average concentrations of individual U isotopes are(3.23±0.14) μg/kg for 238 U,(2.34±0.09)×10^(–2) μg/kg for ^(235)U and(2.05±0.07)×10^(–4) μg/kg for 234 U. Correspondingly, the U isotopic compositions are 155±18 for δ234U and 138±2 for 238U:235U. The U concentrations and isotopic ratios in the Taiwan Strait are similar to those of open ocean seawater, suggesting the dominance of the open ocean input to the strait's U pool.However, river input, as suggested by the slightly lower salinity than that of the open ocean, also affected the U concentrations and isotopic compositions in the strait. From a compilation of U concentrations in the Taiwan Strait and adjacent areas, including the Jiulong Estuary and Zhujiang Estuary, the Xiamen Bay and the northern South China Sea, a strong and significant relationship between U concentration and salinity [U:S; U=(0.093 4±0.002 4)S+(0.092 0±0.061 5)] is revealed, suggesting conservative mixing of U in the Taiwan Strait. To better understand the U geochemistry in the Taiwan Strait, a multiple endmembers mixing model is applied to estimate the contributions of potential sources. The open ocean seawater contributed 69%–95% of U in the Taiwan Strait, with river water approximately 2%, and dust deposition only around 0.13%. Therefore, the model results supported the open ocean input source and the conservative mixing behavior of U derived from the observation of U concentrations and isotopic ratios and U:S ratios. The sediment interstitial water may be an important source of U to the Taiwan Strait with a possible contribution of 3%–29%, consistent with previous investigations based on radium isotopes.However, further investigations are warranted to examine the U concentration in the sediment interstitial water and its input to the overlying seawater in the Taiwan Strait. | CEN Rongrong LIU Yanna XING Na CHEN Min CHENG Hua CAI Yihua | 2017 | Acta Oceanologica Sinica2017，36，3： | 0 |
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