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| 1 | Viral hepatitis update: Progress and perspectives显示文摘Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and mortality.Despite the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and treatment.This review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research directions.For hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food detections.In the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine improvement.On hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and vaccination.Regarding hepatitis D virus,we describe diagnostic methodology,pathogenesis,and therapy.Finally,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance. | María B Pisano Cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado Pamela Valva | 2021 | World Journal of Gastroenterology2021，27，26： | 8 |
| 2 | Functional studies of mesenchymal stem cells derived from adult human adipose tissue显示文摘 | Andrea Dicker Katarina Le Blanc Gaby ?str?m Vanessa van Harmelen Cecilia G?therstr?m Lennart Blomqvist Peter Arner Mikael Rydén | 2005 | Experimental Cell Research2005，，2： | 2 |
| 3 | Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus 显示文摘 | CHRISTOPHER G B SARAH F CECILIA M L | 2010 | PLoS One2010，5，14： | 1 |
| 4 | Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer 显示文摘 | Kalimutho M Di Cecilia S Del Vecchio Blanco G | 2011 | Br J Cancer2011，104，： | 1 |
| 5 | Alberto MT1R8/SIGIRR:an IL-IR/TLR family member with regulatory functions in inflammation and T cell polarization显示文摘 | Cecilia G Hans-Joachim A | | 0，，09： | 1 |
| 6 | A new and efficient procedure for preparing 1,2,3-triazoles 显示文摘 | Romeiro G A Cecilia M de Souza B V | 1997 | Tet- rahedron Letters1997，38，29： | 1 |
| 7 | More intramedullary nails and arthroplasties for treatment of hip fractures in Sweden显示文摘 | Cecilia Rogmark Curt-Lennart Spetz G?ran Garellick | 2010 | Acta Orthopaedica2010，，5： | 1 |
| 8 | In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression显示文摘 | Maria Cecilia G Marcondes Matthew Poling | 2008 | Cellular Immunol2008，254，： | 1 |
| 9 | Epigeneti- cally silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer显示文摘 | Kalimutho M Di Cecilia S Del Vecchio Blanco G | 2011 | Br J Cancer2011，104，11： | 1 |
| 10 | Risk aversion and rising wage inequality显示文摘 | Eve C Cecilia G P | 2002 | Economics Letters2002，77，1： | 1 |
| 11 | Water hyacinths as a resource in agriculture and energy production:A literature review显示文摘 | Carina C G Cecilia M P | 2007 | Waste Management2007，27，： | 1 |
| 12 | Moderating effects of social value orientation on determinants of proenvironmental behavior intention显示文摘 | Tommy G?rling Satoshi Fujii Anita G?rling Cecilia Jakobsson | 2003 | Journal of Environmental Psychology2003，，1： | 1 |
| 13 | Glucose-based total parenteral nutrition does not stimulate glucose uptake by humans tumours 显示文摘 | Fedefieo B Cecilia G Luigi M | 2004 | Clin Nutr2004，23，3： | 1 |
| 14 | Effect of storage on chemical and sensory profiles of peanut pastes prepared with high-oleic and normal peanuts显示文摘 | Riveros Cecilia G Mestrallet Marta G Gayol Maria F | 2010 | Journal of the Science of Food and Agriculture2010，90，15： | 1 |
| 15 | Pathways connecting inflammation and cancer显示文摘 | Paola A Cecilia G Maria G B | 2008 | Curr Opin Genet Dev2008，18，1： | 1 |
| 16 | Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption显示文摘The etiology of most cases of idiopathic bile acid malabsorption (IBAM) is unknown. In this study, a Swedish family with bile acid malabsorption in three consecutive generations was screened for mutations in the ileal apical sodium-bile acid cotransporter gene (ASBT; gene symbol, SLC10A2) and in the genes for several of the nuclear receptors known to be important for ASBT expression: the farnesoid X receptor (FXR) and peroxisome proliferator activated receptor alpha (PPARa). The patients presented with a clinical history of idiopathic chronic watery diarrhea, which was responsive to cholestyramine treatment and consistent with IBAM. Bile acid absorption was determined using 75Se-homocholic acid taurine (SeHCAT); bile acid synthesis was estimated by measuring the plasma levels of 7a-hydroxy-4-cholesten-3-one (C4). The ASBT, FXR, and PPARa genes in the affected and unaffected family members were analyzed using single stranded conformation polymorphism (SSCP), denaturing HPLC, and direct sequencing. No ASBT mutations were identified and the ASBT gene did not segregate withthe bile acid malabsorption phenotype. Similarly, no mutations or polymorphisms were identified in the FXR or PPARa genes associated with the bile acid malabsorption phenotype. These studies indicate that the intestinal bile acid malabsorption in these patients cannot be attributed to defects in ASBT. In the absence of apparent ileal disease, alternative explanations such as accelerated transit through the small intestine may be responsible for the IBAM. | Marco Montagnani Anna Abrahamsson Cecilia Glman Gsta Eggertsen Hanns-Ulrich Marschall Elisa Ravaioli Curt Einarsson Paul A Dawson | 2006 | World Journal of Gastroenterology2006，12，47： | 1 |
| 17 | Heart rate variability and cardiac troponin I are incremental and independent predictors of one-year all-cause mortality after major noncardiac surgery in patients at risk of coronary artery disease显示文摘 | Miodrag Filipovic Raban Jeger Cecilia Probst Thierry Girard Matthias Pfisterer Lorenz Gürke Karl Skarvan Manfred D. Seeberger | 2003 | Journal of the American College of Cardiology2003，，10： | 1 |
| 18 | Temperature dependence of phntoluminescence in ZnO-containing glasses显示文摘 | QIAN G J NIKL M BEI J F PEJCHAL J BACCARO S GIORGI R CECILIA A CHEN G R | 2007 | Optical Materials2007，，30： | 1 |
| 19 | Glucose - based total parenterat nutri- tion does not stimulate glucose up take by humans tumours显示文摘 | Federico B Cecilia G Luigim | 2004 | Clin Nutr2004，23，3： | 1 |
| 20 | Bile Acid Synthesis in Humans Has a Rapid Diurnal Variation That Is Asynchronous With Cholesterol Synthesis显示文摘 | Cecilia G?lman Bo Angelin Mats Rudling | 2005 | Gastroenterology2005，，5： | 1 |
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