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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | Degradation of 2,4-D and 2,4-D in 114 agricultural soils as affected by soil organic carbon content 显示文摘 | Gaultier J Farenhorst A Cathcart J | 2008 | Soil Biology & Biochemistry2008，40，： | 1 |
| 3 | Degradation of 2, 4-D and 2, 4-D in 114 agricultural soils as affected by soil organic carbon content 显示文摘 | GAULTIER J FARENHORST A CATHCART J | 2008 | Soil Biology and Biochemistry2008，40，1： | 1 |
| 4 | Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight obese men显示文摘 | WHYTE L J GILL J M CATHCART A J | 2010 | Metabolism2010，59，10： | 1 |
| 5 | The influence of thymic humoral factor on systemic lupus erythematosus lymphocyte function显示文摘 | WYSENBEEK A J TRAININ N CATHCART M | 1985 | Int J Immunoph1985，7，： | 1 |
| 6 | Rotation length,canola variety and herbicide resistance system affect weed populations and yield显示文摘 | Cathcart R J Topinkab A K Kharbanda P | 2006 | Weed Science2006，54，4： | 1 |
| 7 | Oxygen Uptake and Muscle Desaturation Kinetics during Intermittent Cycling显示文摘 | TURNER A P CATHCART A J | 2006 | Med Sci Sports Exe2006，38，3： | 1 |
| 8 | Degradation of[carboxyl-14C]2,4-D and[ring-U-14C]2,4-D in 114 agricultural soil as affected by soil organic carbon content显示文摘 | Gaultier J Farenhorst A Cathcart J Goddard T | | 0，，： | 1 |
| 9 | Effect of 2 weeks of sprint interval training on health related outcomes in sedentary overweightobese men 显示文摘 | WHYTE L GILL J CATHCART A | 2010 | Metabolism2010，59，10： | 1 |
| 10 | Degradation of2,4-D in 114 agricultural soil as affected by soil organic carbon content显示文摘 | GAULTIER J FARENHORST A CATHCART J | 2008 | Soil Biology and Biochemistry2008，40，5： | 1 |
| 11 | Degradation of 2,4-D in 114 agricultural soil as affected by soil organic carbon content 显示文摘 | GAULTIER J FARENHORST A CATHCART J | 2008 | Soil Biology and Biochemistry2008，40，1： | 1 |
| 12 | The rates of oxidation of several faces of a single crystal of copper as determined with elliptically polarized light显示文摘 | YOUNG F W CATHCART J V GWATHMEY A T | 1956 | Acta Materialia1956，4，1： | 1 |
| 13 | Degradation of 2,4-D in 114 agricultural soil as affected by soil organic carbon content显示文摘 | GAULTIER J FARENHORST A CATHCART J | 2008 | Soil Biology and Biochemistry2008，40，1： | 1 |
| 14 | CML vaccines as a paradigm of the specific immunotherapy of cancer显示文摘 | Pinilla Ibarz J Cathcart K Scheinberg D A | | 0，，02： | 1 |
| 15 | Effect of 2 weekspf sprint interval training on health-related outcomes in seden- tary overweight/obese men 显示文摘 | WCHYTE L J GILL J M CATHCART A J | 2010 | Metabolism2010，59，10： | 1 |
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