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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | GATA3 controls Foxp3^sup +^ regulatory T cell fate during inflammation in mice显示文摘 | Wohlfert Elizabeth A Grainger John R Bouladoux Nicolas Konkel Joanne E Oldenhove Guillaume Ribeiro Carolina Hager Hall Jason A Yagi Ryoji Naik Shruti Bhairavabhotla Ravikiran Paul William E Bosselut Remy Wei Gang Zhao Keji Oukka Mohamed Zhu | 2011 | Journal of Clinical Investigation2011，，11： | 2 |
| 4 | Isolation and structural characterization of a new fibrin (ogen) olytic metaUoproteinase from Bothrops moojeni snake venom 显示文摘 | CAROLINA P B NORIVAL A S TaSSIA R C | 2008 | Toxicon2008，51，： | 1 |
| 5 | Selection of thermotolerant yeast strains Saccharomyces cerevisiae for bioethanol production 显示文摘 | Edgardo A Carolina P Manuel R | 2008 | Enzyme and Technology Microbial2008，，43： | 1 |
| 6 | EGb761blocks MPP+-induced lipid peroxidat ion in mouse corpus striatum显示文摘 | Pat ricia R Belen C Carolina R | 2001 | Neuro-chemical Research2001，26，11： | 1 |
| 7 | Adoptive transfer of effector CD8^sup +^ T cells derived from central memory cells establishes persistent T cell memory in primates显示文摘 | Berger Carolina Jensen Michael C Lansdorp Peter M Gough Mike Elliott Carole Riddell Stanley R | 2008 | Journal of Clinical Investigation2008，，1： | 1 |
| 8 | Effect of extracellular products of Pseud- oalteromonaz atlantiea on the edible crab Cancer pagurus 显示文摘 | Carolina C R Rowley A F | 2004 | Applied and Environment Microbiology2004，70，2： | 1 |
| 9 | Production of biomass and nutraceutical compounds by Spirulina platensis under different temperature and nitrogen regimes 显示文摘 | Luciane M C Christian O R Carolina R R | 2007 | Bioresource Technology2007，，： | 1 |
| 10 | Assessing land-use and land-cover changes in relation to geographic factors and urban planning in the metropolitan area of ConcepciSn (Chile): implications for biodiversity conservation显示文摘 | CAROLINA R JOAN P CORINA B | 2013 | Applied Geography2013，39，： | 1 |
| 11 | Variation in aboveground tree live biomass in a central Amazonian forest:effects of soil and topography显示文摘 | CAROLINA V E WILLIAM E M NAZARE A R | 2006 | Forest Ecology and Management2006，234，： | 1 |
| 12 | The Major Surface Carbohydrates of the Echinococcus granufosus Cyst : Mucin - Type O - Glycans Decorated by Novel Galactose - Based Structures显示文摘 | Alvaro D E Carolina Fontana Adriane R Todeschini | 2009 | Biochemistry2009，48，11： | 1 |
| 13 | Effect of Treatment With Candesartan or Enalapril on Subcutaneous Small Artery Structure in Hypertensive Patients With Noninsulin-Dependent Diabetes Mellitus显示文摘 | Damiano R Enzo P Carolina D | 2005 | Hypertension2005，45，42： | 1 |
| 14 | Thermal protection of β-carotene in re- assembled casein micelles during different processing technologies applied in food industry 显示文摘 | Maria S Carolina G F Ana M R | 2013 | Food Chemistry2013，138，： | 1 |
| 15 | Nutritional and lipid profiles in marine fish species from Brazil 显示文摘 | Carolina E F Margarida A S V Marisilda A R | 2014 | Food Chem2014，160，： | 1 |
| 16 | Selection of thermotolerant yeast strains Saccharomyces cerevisiae for bioethanol production 显示文摘 | Edgardo A Carolina P Manuel R | 2008 | Enzyme and Microbial Technology2008，43，2： | 1 |
| 17 | EGb761 blocks MPP + induced lipid peroxidation in mouse corpus striatum 显示文摘 | Patricia R Belen C Carolina R | 2001 | Neurochemical Research2001，26，11： | 1 |
| 18 | A histological study of shell disease syndrome in the edible crab Cancer pagurus 显示文摘 | CLAIRE L V CAROLINA C R ANDREW F R | 2001 | Diseases of Aquatic Organisms2001，47，： | 1 |
| 19 | Determonation of free and amidated bile acids by high-performance liquid chromatography with evaporative light-scattering mass detection显示文摘 | Carolina C Patrizia S | 1992 | J Lipid Res1992，33，： | 1 |
| 20 | Effect of catalyst preparation and support composition on hydrodesulfurization of dibenzothiophene and maya crude oil显示文摘 | Rana M S Capitaine E M R Carolina Leyva | 2007 | Energy fuels2007，86，9： | 1 |
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