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| 1 | What We Have Learned About Pancreatic Cancer From Mouse Models显示文摘 | Pedro A. Pérez–Mancera Carmen Guerra Mariano Barbacid David A. Tuveson | 2012 | Gastroenterology2012，，5： | 3 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Toll‐Like Receptors and Cytokines are Upregulated during H elicobacter pylori Infection in Children显示文摘 | Hugo Lagunes‐Servin Javier Torres Carmen Maldonado‐Bernal Martha Pérez‐Rodríguez Sara Huerta‐Yépez Armando Madrazo de la Garza Leopoldo Mu?oz‐Pérez Lourdes Flores‐Luna Guillermo Ramón‐García Margarita Camorlinga‐Ponce | 2013 | Helicobacter2013，，6： | 2 |
| 4 | Peripheral arterial disease, type 2 diabetes and postprandial lipidaemia: Is there a link?显示文摘Peripheral arterial disease, manifested as intermittent claudication or critical ischaemia, or identified by an ankle/brachial index < 0.9, is present in at least one in every four patients with type 2 diabetes mellitus.Several reasons exist for peripheral arterial disease indiabetes. In addition to hyperglycaemia, smoking and hypertension, the dyslipidaemia that accompanies type2 diabetes and is characterised by increased triglyceride levels and reduced high-density lipoprotein cholesterol concentrations also seems to contribute to this association. Recent years have witnessed an increased interest in postprandial lipidaemia, as a result of various prospective studies showing that non-fasting triglycerides predict the onset of arteriosclerotic cardiovascular disease better than fasting measurements do. Additionally,the use of certain specific postprandial particle markers,such as apolipoprotein B-48, makes it easier and more simple to approach the postprandial phenomenon. Despite this, only a few studies have evaluated the role of postprandial triglycerides in the development of peripheral arterial disease and type 2 diabetes. The purpose of this review is to examine the epidemiology and risk factors of peripheral arterial disease in type 2 diabetes, focusing on the role of postprandial triglycerides and particles. | Pedro Valdivielso José Ramírez-Bollero Carmen Pérez-López | 2014 | World Journal of Diabetes2014，5，5： | 2 |
| 5 | Vaccines and recommendations for their use in inflammatory bowel disease显示文摘The patient with inflammatory bowel disease will be predisposed to numerous infections due their immune status. It is therefore important to understand the immune and serologic status at diagnosis and to put the patient into an adapted vaccination program. This program would be applied differently according to two patient groups: the immunocompromised and the non-immunocom-promised. In general, the first group would avoid the use of live-virus vaccines, and in all cases, inflammatory bowel disease treatment would take precedence over vaccine risk. It is important to individualize vaccination schedules according to the type of patient, the treatment used and the disease pattern.In addition, patient with inflammatory bowel disease should be considered for the following vaccines: varicella vaccine, human papilloma virus, influenza, pneumococcal polysaccharide vaccine and hepatitis B vaccine. | María Dolores Sánchez-Tembleque Carmen Corella Jose L Pérez-Calle | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 6 | Silent diabetic nephropathy显示文摘AIM: To examine the risk of renal events in patients with biopsy-proven diabetic nephropathy(DN) and its possible associated factors.METHODS: Clinical and histological data of 60 patients diagnosed with diabetic nephropathy were retrospectively collected. Patients with evidence or suspicion of other nephropathies were excluded from the study. The final event was defined as renal replacement therapy(RRT) initiation or progression of chronic kidney disease(CKD), according to the KDIGO 2012 definition of a decrease in CKD category and a decrease in GFR of 25% or more. RESULTS: A total of 45 patients with a follow-up of at least 3 mo were included. Most of the patients presented type 2 DM, with a median age of 58.3 years old. The time of evolution of DM was 9.6 ± 7.8 years, although in 13 patients, it was less than 5 years. A total of 62% of patients reached the final event in a mean period of 3.4 years(95%CI: 2.1-4.7), with 21 of them requiring dialysis. The factors that were independently associated with renal survival were estimated glomerular filtration rate(e GFR) at the time of biopsy, cardiovascular disease(CVD) history and Hb A1 c less than 7%. Therefore, for each 10 m L/min per 1.73 m2 reduction in e GFR, we obtained a DN progression risk of HR = 2(1.3-3.0)(P = 0.001); patients with CVD were at greater risk for DN progression(HR = 2.8, 1.1-7.1, P = 0.032), and CKD patients with Hb A1 c < 7% demonstrated greater renal risk than patients with Hb A1 c ≥ 7%, with an HR of 2.9(1.0-8.4)(P = 0.054).CONCLUSION: A past history of CVD is a risk factor for DN progression. Levels of Hb A1 c less than 7% could favor an e GFR decrease in these patients. | Katia López-Revuelta Patricia Pea Galdo Ramona Stanescu Leticia Parejo Carmen Guerrero Elia Pérez-Fernández | 2014 | World Journal of Nephrology2014，3，1： | 2 |
| 7 | Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer 显示文摘 | Monica S Antonella G Carmen P | 2005 | Oncogene2005，24，： | 1 |
| 8 | Two galactomannan preparations from seeds from Mimosa scabrella (bracatinga): Complexation with oxovanadium(W/V) and cytotoxicity on HeLa cells显示文摘 | GUILHERMINA R N CARMEN L P ANAL R | 2009 | J Inorg Bioehem2009，103，： | 1 |
| 9 | Mix and Match: Product Compatibility without Network Externalities 显示文摘 | MATUTES CARMEN REGIBEAU P | 1988 | RAND Journal of Economies1988，19，： | 1 |
| 10 | Constitute activations of STAT3 oncogene product in human ovarian carcinoma cells 显示文摘 | Carmen P Kevin R | 2000 | Gynecol Oncol2000，79，1： | 1 |
| 11 | Down-regulation of RIP expression by 17-dimethylaminoethylamino-17-demethoxy- geldanamycin promotes TRAIL-induced apoptosis in breast tumor cells 显示文摘 | Carmen P Ana IP Abelardo LR | 2010 | Cancer Lett2010，287，： | 1 |
| 12 | Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts 显示文摘 | Sato T del Carmen Ovejero M Hou P | 1997 | J Cell Sci1997，110，： | 1 |
| 13 | The results of open reduction and internal fixation of distal femur fractures using a biologic (indirect) reduction technique显示文摘 | Bolhofner BR Carmen B Clifford P | 1996 | J Orthop Trauma1996，10，6： | 1 |
| 14 | Biochemical changes and quality loss during chilled storage of farmd turbot (Psetta maxima)显示文摘 | SANTIAGO P A CARMEN P | 2005 | Food Chemistry2005，90，： | 1 |
| 15 | Protein expression by a Beijing strain differs from that of another clinical isolate and Mycobacteriu tuberculosis H37Rv 显示文摘 | Carmen P Joanna CB Helen RF | 2005 | Microbiology2005，151，： | 1 |
| 16 | Comprehensive analysis of major and minor chlorogenic acid and lactones in econo- mically relevant Brazilian coffee cultivars 显示文摘 | Daniel P Adriana F Carmen MD | 2008 | Food Chemistry2008，106，2： | 1 |
| 17 | Shift in Japanese encephalitis virus (JEV) genotype circulating in northern Vietnam: implications for frequent introductions of JEV from Southeast Asia to East Asia显示文摘 | Nga P T del Carmen Parquet M Cuong V D | 2004 | J Gen Virol2004，85，6： | 1 |
| 18 | Amino acid-based surfactants显示文摘 | María Rosa Infante Lourdes Pérez Aurora Pinazo Pere Clapés María Carmen Morán Marta Angelet María Teresa García María Pilar Vinardell | 2004 | Comptes rendus - Chimie2004，，6： | 1 |
| 19 | Method development for the simultaneous determination of methylmercury and inorganic mercury in seafood显示文摘 | Ariane V Z Sergio C Carmen I P | 2014 | Food Control2014，46，1： | 1 |
| 20 | Leptin Impairs Insulin Signaling in Rat Adipocytes显示文摘 | Coralia P Carmen FG Teresa FA | 2004 | Diabetes2004，53，： | 1 |
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