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| 1 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | Review on thermal energy storage with phase change: materials, heat transfer analysis and applications显示文摘 | Belén Zalba José M a Mar??n Luisa F. Cabeza Harald Mehling | 2002 | Applied Thermal Engineering2002，，3： | 3 |
| 3 | Molecular genetics of berry colour variation in table grape显示文摘 | Diego Lijavetzky Leonor Ruiz-García José A. Cabezas María T. Andrés Gemma Bravo Ana Ibá?ez Juan Carre?o Félix Cabello Javier Ibá?ez José M. Martínez-Zapater | 2006 | Molecular Genetics and Genomics2006，，5： | 2 |
| 4 | Materials used as PCM in thermal energy storage in buildings: a review 显示文摘 | Cabeza E Castell A Barreneche C Graeia A Fernandez A | 2011 | Renewable and Sustainable Energy Reviews2011，15，3： | 1 |
| 5 | A fully on-line adaptive BCI显示文摘 | Vidaurre C Schlogl A Cabeza A | 2006 | IEEE Trans Biomed Eng2006，53，6： | 1 |
| 6 | Analysis of Reservoir Storage Reallocations 显示文摘 | Wurbs R A Cabezas L M | 1987 | Journal of Hydrology1987，，92： | 1 |
| 7 | Lipaemia,inflammation and atherosclerosis:novel opportunities in the understanding and treatment of atherosclerosis显示文摘 | Van-OOSTROM A J Van-WIJK J CABEZAS M C | 2004 | Drugs2004，64，2： | 1 |
| 8 | Materials used as PCM in thermal energy storage in buildings: A review 显示文摘 | Cabeza L F Castell A Barreneche C | 2011 | Renewable Sustainable Energy Rev2011，15，3： | 1 |
| 9 | Materials used as PCM in thermal energy storage in bui|dings: a review显示文摘 | Cabeza L F Caste11 A Barreneche C | 2011 | Renewable and Sustainable Energy Reviews2011，1，3： | 1 |
| 10 | State of the art on high temperature thermal energy storage for power generation (1): Concepts, materials and modellization 显示文摘 | Gil A Medrano M Martorell I Lizaro A Dolado P Zalba B Cabeza L F | 2010 | Renewable and Sustainable Energy Reviews2010，14，1： | 1 |
| 11 | Carbohydrate contents,and glycosidase and glycosyl transferase activities in tissues from streptozotocin diabetic mice显示文摘 | Serrano MA Cabezas JA Reglero A | 1985 | Comp Biochem Physiol B1985，80，3： | 1 |
| 12 | Stereo matc-hing using gradient similarity and locally adaptivesupport-weight显示文摘 | De-maeztu L Villanueva A Cabeza R | 2011 | Pattern Recognition Letters2011，32，13： | 1 |
| 13 | Urine polyamines determinition using dansyl chloride derivatization in soilidphase ex- traction cartridges and HPLC 显示文摘 | LEGUA C M FALCO P C CABEZA A S | 1999 | Analyst1999，124，： | 1 |
| 14 | Percutaneous cervical nucleoplas- ty using coblation technology:clinical results in fifty consecutive cases 显示文摘 | Nardi PV Cabezas D Cesaroni A | 2005 | Acta Neurochir Suppl2005，92，： | 1 |
| 15 | Incidence of tran-sient ischemic attacks and minor ischemic strokes inSegovia,Spain显示文摘 | Sempere A P Duarte J Cabezas C | 1996 | Stroke1996，27，4： | 1 |
| 16 | Cogni-tive deterioration due to GH deficiency in patients with traumatic brain injury:a preliminary report显示文摘 | Leon-Carrion J Leal-Cerro A Cabezas FM | 2007 | Brain Inj2007，21，8： | 1 |
| 17 | Stereo matching using gradient similarity and locally adaptive support-weight显示文摘 | De-Maeztu L Villanueva A Cabeza R | 2011 | Pattern Recognition Letters2011，32，13： | 1 |
| 18 | Social disparities in breast and cervical cancer preventive practices显示文摘 | Cabeza E Esteva M Pujol A | 2007 | Eur J Cancer Prev2007，16，4： | 1 |
| 19 | Comparison of the pharmacokinetics of moxidectin ( Equest~ ) and iver- mectin(Eqvalan~ )in horses显示文摘 | PI~REZ R CABEZAS I GARC~A M | 1999 | J Vet Pharmacol Ther- ap1999，22，3： | 1 |
| 20 | Percutaneous cervical nucleoplasty using coblation technology: Clinical results in fifty consecutive cases 显示文摘 | Nardi PV Cabezas D Cesaroni A | 2005 | Acta Neurochir Suppl2005，92，： | 1 |
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