|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 2 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 3 | 高掺量粉煤灰高延性水泥基复合材料的制备和性能显示文摘高延性水泥基复合材料(high ductility cementitious composites,HDCC)是一种具有应变硬化、多缝开裂和高延性等特性的新型纤维增强水泥基复合材料,其材料设计必须取得基体韧度、界面黏结和纤维特性三者的最优组合,因此,HDCC的制备必须优选原材料和优化配合比,以取得最优的材料制备技术。从配合比设计入手,研究了粉煤灰含量、胶砂比等对HDCC力学性能的影响,优化了特定材料下的材料制备技术。结果表明:粉煤灰含量、胶砂比和养护条件对HDCC的拉伸性能均具有较大的影响。随着粉煤灰掺量的增大,砂含量的降低,拉伸应变增大。当砂含量较高时,基体开裂韧度较高,基体的极限拉伸应力下对应的极限拉伸应变较小,然而随着应力的下降,复合材料仍然能维持相当大的应变。 | 庞超明 LEUNG C K Y 孙伟 | 2009 | 硅酸盐学报2009，37，12： | 30 |
| 4 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 5 | Vascular endothelial growth factor receptor 2(VEGFR-2) plays a key role in vasculogenic mimicry formation,neovascularization and tumor initiation by Glioma stem-like cells显示文摘Human glioblastomas(GBM)are thought to be initiated by glioma stem-like cells(GSLCs).GSLCs also participate in tumor neovascularization by transdifferentiating into vascular endothelial cells.Here,we report a critical role of GSLCs in the formation of vasculogenic mimicry(VM),which defines channels lined by tumor cells to supply nutrients to early growing tumors and | Yao X Ping Y Liu Y Chen K Yoshimura T Liu M Gong W Chen C Niu Q Guo D Zhang X Wang JM Bian X | 2013 | 中国神经肿瘤杂志2013，11，3： | 23 |
| 6 | Adenoid cystic carcinoma of breast: Recent advances显示文摘Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features. | Kosuke Miyai Mary R Schwartz Mukul K Divatia Rose C Anton Yong Wook Park Alberto G Ayala Jae Y Ro | 2014 | World Journal of Clinical Cases2014，2，12： | 16 |
| 7 | 推荐以“EBV相关肺癌”术语替代和扩展肺淋巴上皮瘤样癌的组织学谱系显示文摘肺淋巴上皮瘤样癌(LELC)是一种罕见的EBV相关性癌,其组织学特征为癌细胞呈合体细胞样生长,伴显著的淋巴细胞浸润,组织学上与未分化型鼻咽癌难以区分。研究发现LELC亦可显示非经典组织学形态且缺乏显著的淋巴细胞浸润。作者选取61例肺LELC病例进行全面临床病理分析,并使用免疫组化分析软件对浸润淋巴细胞进行自动定量分析,发现肺LELC形态学上存在连续性谱系,呈现从富于淋巴细胞浸润的经典型未分化LELC至极少淋巴细胞浸润的非经典型组织学形态。 | Yeh Y C Kao H L Lee K L | 2019 | 临床与实验病理学杂志2019，35，5： | 12 |
| 8 | Primary squamous cell carcinoma of the rectum: An update and implications for treatment显示文摘AIM: To provide an update on the aetiology, pathogenesis, diagnosis, staging and management of rectal squamous cell carcinoma(SCC).METHODS: A systematic review was conducted according to the preferred reporting items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of Ovid MEDLINE was performed with the reference list of selected articles reviewed to ensure all relevant publications were captured. The search strategy was limited to the English language, spanning from 1946 to 2015. A qualitative analysis was undertaken examining patient demographics, clinical presentation, diagnosis, staging, treatment and outcome. The quantitaive analysis was limited to data extracted on treatment and outcomes including radiological, clinical and pathological complete response where available. The narrative and quantitative review were synthesised in concert.RESULTS: The search identified 487 articles in total with 79 included in the qualitative review. The quantitative analysis involved 63 articles, consisting of 43 case reports and 20 case series with a total of 142 individual cases. The underlying pathogenesis of rectal SCC while unclear, continues to be defined, with increasing evidence of a metaplasia-dysplasia-carcinoma sequence and a possible role for human papilloma virus in this progression. The presentation is similar to rectal adenocarcinoma, with a diagnosis confirmed by endoscopic biopsy. Many presumed rectal SCC's are in fact an extension of an anal SCC, and cytokeratin markers are a useful adjunct in this distinction. Staging is most accurately reflected by the tumour-nodemetastasis classification for rectal adenocarcinoma. It involves examining locoregional disease by way of magnetic resonance imaging and/or endorectal ultrasound, with systemic spread excluded by way of computed tomography. Positron emission tomography is integral in the workup to exclude an external siteof primary SCC with metastasis to the rectum. While the optimal treatment remains as yet undefined, recent studies have demonstrated a global shift away from surgery towards definitive chemoradiotherapy as primary treatment. Pooled overall survival was calculated to be 86% in patients managed with chemoradiation compared with 48% for those treated traditionally with surgery. Furthermore, local recurrence and metastatic rates were 25% vs 10% and 30% vs 13% for the chemoradiation vs conventional treatment cohorts.CONCLUSION: The changing paradigm in the treatment of rectal SCC holds great promise for improved outcomes in this rare disease. | Glen R Guerra Cherng H Kong Satish K Warrier Andrew C Lynch Alexander G Heriot Samuel Y Ngan | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 5 |
| 9 | Purified human bone marrow multipotent mesenchymal stem cells regenerate infarcted myocardium in experimental rats显示文摘 | Zhang S Jia Z Ge J Gong L Ma Y Li T Guo J Chen P Hu Q Zhang P Liu Y Li Z Ma K Li L Zhou C | 2006 | 中国生物学文摘2006，20，5： | 5 |
| 10 | 血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性显示文摘血流介导的血管舒张功能(flow-mediated vasodilation,FMD)已被用于评估内皮功能。充血性剪切应力(hyperemic shear stress,HSS,一种FMD的刺激因素)、硝酸甘油诱导的血管舒张(nitroglycerine-induced vasodilation,NID,非内皮依赖性血管舒张指数)以及基线肱动脉直径(brachial artery diameter,BAD)也参与血管舒张反应。 | 刘青 叶鹏 Maruhashi T Iwamoto Y Kajikawa M Oda N Kishimoto S Matsui S Hashimoto H Aibara Y Yusoff FM Hidaka T Kihara Y Chayama K Noma K Nakashima A Goto C Hida E Higashi Y | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 11 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 12 | Practice of breast self-examination among high risk Chinese women in Hong Kong显示文摘The incidence of breast cancer in Hong Kong is increasing and breast self examination (BSE) as a screening tool is becoming more popular, especially among first degree relatives (FDR) of breast cancer victims BSE may be more applicable to Chinese women as their breast size is smaller This study explores the BSE practice in this group of women Methods A cross sectional study was conducted by sending questionnaires to 330 FDR of breast cancer patients treated in the Department of Surgery, University of Hong Kong BSE behavior was studied with respect to its frequency, awareness, completeness and confidence of practice Results 110 subjects returned the questionnaires with a response rate of 33% The mean age of the respondent was 37 years Only 57 women (52%) were practicers The practicers have a stronger BSE awareness ( P <0 01) and a lower mean score on thought barriers ( P =0 002) than the non practicers 40% of the practicers gain their BSE knowledge through clinicians and their mean period of practice was 3 2 years 68% of the practicers performed BSE completely The overall confidence rate was 35%, but the rate was 43% among those who performed complete BSE Thirteen factors possibly related to the completeness and rate of confidence of BSE examination were studied The only factor that significantly determined completeness was the time spent for each examination ( P =0 002) The complete practicers required a longer time than the incomplete practicers (6 60 and 2 96?min, respectively) Women with a stronger BSE intention ( P =0 001) and a lower mean score on thought barriers ( P =0 001) performed the examination confidently Conclusions Slightly over half of the FDR practice BSE The majority perform a complete BSE but they are not confident in finding abnormalities Women spending more time on BSE are associated with a higher rate of completeness However, only those with a stronger BSE intention and lesser thought barriers are more confident in their | Kelvin K C Ng, Fung S Y and Louis W C Chow DepartmentofSurgery (NgKKCandChowLWC)&NursingStudies (FungSY ) ,TheUniversityofHongKong ,QueenMaryHospital ,HongKong ,China | 2000 | Chinese Medical Journal2000，，12： | 4 |
| 13 | 求解动态无功优化问题的混合免疫遗传算法显示文摘无功优化是电力系统运行中提高经济性和电压安全性的重要措施,为防止静态无功优化可能导致无功控制设备的频繁操作,考虑并联电容器投切组数和有载调压变压器变比档位的调节次数约束,建立了电力系统动态无功优化模型。提出免疫遗传算法与非线性内点法相结合的混合算法进行求解,其中免疫遗传算法处理离散变量,非线性内点法处理连续变量,并在免疫遗传算法中设计独特的编码方式,使抗体能够自动满足动态约束。采用IEEE14系统的24时段无功优化问题进行仿真计算,动态无功优化后离散控制设备的调节次数很少,有功损耗比静态优化结果仅有轻微增加,算例结果验证了混合免疫算法的有效性。 | 刘方 颜伟 徐国禹 CHUNG C Y WONG K P | 2006 | 中国电力2006，39，8： | 4 |
| 14 | 查看详情显示文摘 | W C Huang H Y Tam P K A Wai X Y Dong H Ming J P Xie | | 中国物理快报(英文版)0，，： | 4 |
| 15 | 染料敏化分解水制氢技术进展显示文摘介绍了染料敏化分解水制氢的基本原理。综述了染料分子的选取,使用氧化还原调节剂的机理和研究进展。指出染料分子对光谱的吸收特性,激发态染料分子能级与半导体导带的相对位置,染料分子与半导体的吸附情况,表面键合强度直接影响对光子的吸收,电子的注入,从而影响产氢量。此外,I-/I3-作为氧化还原调节剂可有效还原染料分子,实现持续产氢。最后提出了染料敏化分解水制氢的间歇式反应器结构,以及通过选择用于敏化的半导体来提高产氢率的思路。 | 倪萌 LEUNG MICHAEL K H LEUNG DENNIS Y C | 2006 | 电源技术2006，30，10： | 3 |
| 16 | 云南省农村地区男男性接触者与HIV相关的风险行为显示文摘目的探讨中国农村地区男男性接触者(MSM)与艾滋病病毒(HIV)相关的风险行为的具体特点和问题。方法采用半结构化深度访谈的方式进行定性研究。通过一个当地的MSM联系网络,以滚雪球和相互转告的方式招集了24名访谈对象。主要测量指标是与HIV有关的风险行为的上升情况。结果在中国农村地区,风险行为、社会歧视、独生子女政策以及传统中医的观念,在HIV的传播中都起着重要的作用。在中国,许多MSM过着双重生活;调查显示,安全套的使用情况也是因人而异,使风险行为'合理化'的意图是决定是否使用安全套的主要因素;就泌尿生殖系统的问题主动寻求医疗帮助的现象很不普遍,而现有卫生系统以及医务人员对此问题表现出来的不敏感,也进一步加剧了这种现象。结论在资源匮乏的农村地区,MSM人群存在着HIV流行的趋势,并有向普通人群传播的危险。 | 张建波 黄志威 T S K Kong D C Y Ling | 2007 | 中国艾滋病性病2007，13，5： | 3 |
| 17 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 18 | Centrifuge modeling of transport processes for pollutants in soils显示文摘 | Arulanandan K Thompson P Y Kutter B L Meegoda N J Muraleetharan K K Yogachandran C | 1988 | Journal of Geotechnical Engineering Division American Society of Civil Engineering1988，，： | 2 |
| 19 | Clinical role of β-lactam/β-lactamase inhibitor combinations 显示文摘 | Lee N Yuen K Y Kumana C R | 2003 | Drugs2003，63，14： | 2 |
| 20 | Methyloxime-substituted aminopyrrolidine: A new surrogate for 7-basic group of quinolone 显示文摘 | Hong C Y Kim Y K Lee Y H | 1998 | Bioorg Med Chem Lett1998，，8： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员