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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 3 | 查看详情显示文摘 | Feltin E Carlin J F Dorsaz J Christmann G Butte R Latigt M Ilegems M Grandjean N | | 0，，： | 1 |
| 4 | Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance显示文摘 | Sun Y Butte N F Garcia J M | 2008 | Endocrinology2008，149，2： | 1 |
| 5 | Profound obesity associated with a balanced translocation that disrupts the SIM1 gene 显示文摘 | Holder J L Butte N F Zinn A R | 2000 | Human Molecular Genetics2000，9，1： | 1 |
| 6 | 查看详情显示文摘 | Feltin E Christmann G Dorsaz J Castiglia A Carlin J F Butte R Grandjean N Christopoulos S Baldassarri G Hogersthal H V Grundy A J D Lagoudakis P G Baumberg J J | | 0，，： | 1 |
| 7 | Energy requirements of infants 显示文摘 | BUTTE N F | 2005 | Public Health Nutr2005，8，7： | 1 |
| 8 | The fluvial flux of nitrate from the UK terrestrial biosphere - An estimate of national-scale in-stream nitrate loss using an export coefficient model 显示文摘 | Worrall F Butt T Howden N | 2012 | Journal of Hydrology2012，，： | 1 |
| 9 | Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance显示文摘 | Sun Y Butte N F Garcia J M | 2008 | End ocrinology2008，149，2： | 1 |
| 10 | Report of the working group on energy requirements of infants, children and adolescents 显示文摘 | BUTTE N F HENRY C J K TORUN B | 1996 | Eur J Clin Nutr1996，50，1： | 1 |
| 11 | Adjustmentsin energy expenditure and substrate utilization duringlate pregnancy and lactation显示文摘 | Butte N F Hopkinson J M Mehta N | 1999 | Am J Clin Nutr1999，69，2： | 1 |
| 12 | Characterization of adult ghrelinand shrelin receptor knocout mice under positive and negative energy balance显示文摘 | Sun Y Butte N F Garcia J M | 2008 | Endocrinology2008，149，2： | 1 |
| 13 | Leptin in human reproduction:serum leptin levels in pregnant and lactating women 显示文摘 | Butte N F Hopkinson J M Nicolson M A | 1997 | Endocrinol Metab1997，82，： | 1 |
| 14 | Energy requirements derived from total energy expenditure and energy deposition during the first 2 y of life 显示文摘 | BUTTE N F WONG W W HOPKINSON J M | 2000 | Am J Clin Nutr2000，72，6： | 1 |
| 15 | Energy requirements during pregnancy and consequences of deviations from requirement on fetal outcome显示文摘 | Butte N F | 2005 | Nestle Nutrition Workshop Series Pediatric Program2005，55，： | 1 |
| 16 | Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance显示文摘 | Sun Y Butte N F Garcia J M | 2008 | Endocrinology2008，149，： | 1 |
| 17 | Assessing physical activity using wearable monitors:Measures of physical activity显示文摘 | BUTTE N F EKELUND U WESTERTERP K R | 2012 | Med Sci Sports Exe2012，44，11： | 1 |
| 18 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infec Dis2010，10，9： | 1 |
| 19 | Charac-terization of adult ghrelin and ghrelin receptor knock-out mice under positive and negative energy balance显示文摘 | SUN Y BUTTE N F GARCIA J M | 2008 | Endocrinology?2008，149，2： | 1 |
| 20 | Fat Intake of Children in Relation to Energy Requirements显示文摘 | BUTTE N F | 2000 | Am J Clin Nutr2000，72，5： | 1 |
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