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| 1 | Veno occlusive disease: Update on clinical management显示文摘Hepatic veno-occlusive disease is a clinical syndrome characterized by hepatomegaly, ascites, weight gain and jaundice, due to sinusoidal congestion which can be caused by alkaloid ingestion, but the most frequent cause is haematopoietic stem cell transplantation (STC) and is also seen after solid organ transplantation. The incidence of veno occlusive disease (VOD) after STC ranges from 0 to 70%, but is decreasing. Survival is good when VOD is a mild form, but when it is severe and associated with an increase of hepatic venous pressure gradient > 20 mmHg, and mortality is about 90%. Prevention remains the best therapeutic strategy, by using non-myeloablative conditioning regimens before STC. Prophylactic administration of ursodeoxycholic acid, being an antioxidant and antiapoptotic agent, can have some benefit in reducing overall mortality. Defibrotide, which has pro-fibrinolytic and antithrombotic properties, is the most effective therapy; decompression of the sinusoids by a transjugular intrahepatic portosystemic shunt (TIPS) can be tried, especially to treat VOD after liver transplantation and when multiorgan failure (MOF) is not present. Liver transplantation can be the last option, but can not be considered a standard rescue therapy, because usually the concomitant presence of multiorgan failure contraindicates this procedure. | M Senzolo G Germani E Cholongitas P Burra AK Burroughs | 2007 | World Journal of Gastroenterology2007，13，29： | 19 |
| 2 | New insights into the coagulopathy of liver disease and liver transplantation显示文摘The liver is an essential player in the pathway of coagulation in both primary and secondary haemostasis. Only von Willebrand factor is not synthetised by the liver, thus liver failure is associated with impairment of coagulation. However, recently it has been shown that the delicate balance between pro and antithrombotic factors synthetised by the liver might be reset to a lower level in patients with chronic liver disease. Therefore, these patients might not be really anticoagulated in stable condition and bleeding may be caused only when additional factors, such as infections, supervene. Portal hypertension plays an important role in coagulopathy in liver disease, reducing the number of circulating platelets, but platelet function and secretion of thrombopoietin have been also shown to be impaired in patients with liver disease. Vitamin K deficiency may coexist, so that abnormal clotting factors are produced due to lack of gamma carboxylation. Moreover during liver failure, there is a reduced capacity to clear activated haemostatic proteins and protein inhibitor complexes from the circulation. Usually therapy for coagulation disorders in liver disease is needed only during bleeding or before invasive procedures. When end stage liver disease occurs, liver transplantation is the only treatment available, which can restore normal haemostasis, and correct genetic clotting defects, such as haemophilia or factor V Leiden mutation. During liver transplantation haemorrage may occur due to the pre-existing hypocoagulable state, the collateral circulation caused by portal hypertension and increased fibrinolysis which occurs during this surgery. | M Senzolo P Burra E Cholongitas AK Burroughs | 2006 | World Journal of Gastroenterology2006，12，48： | 12 |
| 3 | Soil erosion modeling using ANSWERS and geographical information system显示文摘 | Roo de A p J Hazelhoff L Burrough P A | 1980 | Earth Surface Processes and Landforms1980，14，： | 1 |
| 4 | An analytic model for the free in-plane vibration of beams of variable curvature and depth 显示文摘 | Charpie J P Burroughs C B | 1993 | Journal of the Acoustical Society of America1993，94，： | 1 |
| 5 | Multiscal sources of spatial variability in soil variation显示文摘 | | 1983 | Journal of Soil Science1983，34，： | 1 |
| 6 | Facilitating and rewarding creativity during new product development显示文摘 | BURROUGHS J E DAHL D W MOREAU C P | 2011 | Journal of Marketing2011，75，4： | 1 |
| 7 | Fuzzy Reasoning: A New Quantitative Aid for Land Evaluation显示文摘 | Liu C Burrough P A | 1987 | Soil Survey and Land Evaluation1987，7，： | 1 |
| 8 | Lamivudine prophylaxis against reinfection in liver transplantation for hepatitis B cirrhosis显示文摘 | L Grellier D Mutimer M Ahmed D Brown AK Burroughs K Rolles P McMaster P Beranek F Kennedy H Kibbler P McPhillips E Elias G Dusheiko | 1996 | 1996 (9036)1996，，9036： | 1 |
| 9 | Soil variability: a late 20 century view显示文摘 | Burrough P A | 1993 | Soils and Fertilizers1993，56，5： | 1 |
| 10 | Immunologic reeonstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient 显示文摘 | LIU P SANTISTEBAN I BURROUGHS L M | 2009 | Clin Immunol2009，130，2： | 1 |
| 11 | Soil acidification from atmospheric ammonium sulphate in forest canopy throughfall显示文摘 | van Breemen N Burrough P A Velthorst E J | 1982 | Nature1982，299，5883： | 1 |
| 12 | Purification and properties of virus particles, infect ions subviral particles and cores of bluetongue virus serotypes J and 4 显示文摘 | Mertens P P Burroughs J N Anderson J | 1987 | Virology1987，157，2： | 1 |
| 13 | Competitive ELISA for the detection of antibodies against epizootic haemorrhagic disease of deer virus 显示文摘 | Mertens P P C Burroughs J N | 1995 | Journal of Virological Methods1995，55，： | 1 |
| 14 | The Fractal Dimensions of land scapes and other environmental data显示文摘 | Burrough P A | 1981 | Nature1981，294，： | 1 |
| 15 | Facilita- ting and rewarding creativity during new product develo- pment显示文摘 | Burroughs J E Dahl D W Moreau C P | 2011 | Journal of Marketing2011，75，4： | 1 |
| 16 | The atomic structure of the bluetongue virus core显示文摘 | Burroughs J N Gouet P | 1998 | Nature1998，395，： | 1 |
| 17 | Multiscal sources of spatial variability in soil variation显示文摘 | Burrough P A | 1987 | Journal of soil science1987，34，： | 1 |
| 18 | Enhanced infectivi- ty of modified bluetongue virus particles for two insect cell lines and for two Culicoides vector species显示文摘 | Mertens P P Burroughs J N Walton A | 1996 | Virology1996，217，： | 1 |
| 19 | Soil variability: a late 20th century view 显示文摘 | BURROUGH P A | 1993 | Soil and Fertilizers1993，56，5： | 1 |
| 20 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
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