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| 1 | Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients显示文摘AIM: To analyze the correlation between cytokineinduced killer (CIK) cells adoptive immunotherapy and cancer-related death in gastric cancer patients. METHODS: One hundred and fifty-six gastric cancer patients after operation at the Third Affiliated Hospital of Soochow University were enrolled in this study. Their clinical data including demographic characteristics, operation time, tumor size, pathological type and staging, tumor metastasis, outcome of chemotherapy or CIK cells adoptive immunotherapy, survival time or time of death were collected with a standard structured questionnaire. Kaplan-Meier method was used to estimate the median survival time, and the 2- and 5- year survival rates. Hazard risk (HR) and 95% confidence interval (95% CI) of CIK cells adoptive immunotherapy for gastric cancer were calculated using the two-stage time-dependent covariates Cox model. RESULTS: The survival time of gastric cancer patients was longer after CIK cells adoptive immunotherapy than after chemotherapy (χ 2 = 10.907, P = 0.001). The median survival time of gastric cancer patients was also longer after CIK cells adoptive immunotherapy than after chemotherapy (49 mo vs 27 mo, P < 0.05). The 2- and 5-year survival rates of gastric cancer patients were significantly higher after CIK cells adoptive immunotherapy than after chemotherapy (73.5% vs 52.6%, 40.4% vs 23.9%, P < 0.05). A significant difference was observed in the survival curve for patients who received CIK cells adoptive immunotherapy (0, 1-10, 11-25, and over 25 frequencies) (χ 2 = 14.534, P = 0.002). The frequencies of CIK cells adoptive immunotherapy were significantly related with the decreasing risk of death in gastric cancer patients after adjustment for sex and age of the patients, tumor stage and relapse (HR = 0.54, 95% CI: 0.36-0.80) when the first stage Cox model was used to define the subjects who remained alive beyond 36 mo as survivors. However, no correlation was observed between the frequencies of death in CIK cells adoptive immunotherapy and the risk of gastric cancer patients (HR = 1.09, 95% CI: 0.63-0.89) when the second stage Cox model was used to define the subjects who survived for more than 36 mo as survivors. CONCLUSION: The survival time of the gastric cancer patients treated with chemotherapy combined with CIK cells adoptive immunotherapy is significantly longer than that of the patients treated with chemotherapy alone and increasing the frequency of CIK cells adoptive immunotherapy seems to benefit patients more. | Jing-Ting Jiang, Chang-Ping Wu, Lu-Jun Chen, Xiao Zheng, Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China Yi-Bei Zhu, Jing Sun, Xue-Guang Zhang, Key Laboratory of Stem Cell of Jiangsu Province, Institute of Biotechnology, Key Laboratory of Clinical Immunology of Jiangsu Province, Soochow University, Suzhou 215123, Jiangsu Province, China Yue-Ping Shen, Wen-Xiang Wei, Department of Medicine, Soochow University, Suzhou 215123, Jiangsu Province, China Bin-Feng Lu, Department of Immunology, University of Pitts- burgh School of Medicine, Pittsburgh, PA 15261, United States | 2010 | World Journal of Gastroenterology2010，16，48： | 82 |
| 2 | 一种环境友好的鞣制工艺显示文摘研制一种新的鞣制工艺(亮湿革),用此工艺可以生产出一种合格的汽车内饰浅色革。此工艺是无铬、无醛、无有机溶剂挥发的绿色工艺。工艺的重点是使用了凯米拉公司提供的无毒、无害、绿色、安全的鞣剂。与传统的铬鞣革和醛鞣革相比,新工艺无论对环境或在经济上考虑都有很大的优势,具体来说,与传统的铬鞣革相比,可使废水中化学需氧量(COD)降低60%,悬浮液体降低61%,氮含量降低65%,此外这种工艺生产出的亮湿革的挥发性化合物比蓝湿革降低43%,比白湿革降低8%,更为重要的是,真正地做到了无铬废水排放。 | Anna Bacardit Stefan vander Burgh Jordi Armengol Luis Ollé 孙海云 金博 | 2014 | 皮革与化工2014，31，4： | 3 |
| 3 | 一种新的环境友好型鞣制方法评价显示文摘研究的目的旨在研发一种新的生产白色革的鞣制方法(我们称之为亮湿皮),以满足汽车革的所有要求。这种新的鞣制方法获得的皮革不含铬、醛、醛前体和有机溶剂。这个新体系应用来自芬兰凯米拉的Tanfor T系统,对人类和环境安全,不属于有害类。目前传统的鞣制方法通常有铬鞣革(蓝湿皮)和醛鞣革(白湿皮),新系统较之具有经济和环保优势。据此,新的方法降低COD非常显著。更具体地说,新系统比铬鞣降低了60%的COD、60%的固体悬浮物、65%的氮,是一种环境友好的方法。此外,亮湿皮减少挥发性物质的量,相对白湿皮43%,相对蓝湿皮8%。更重要的是新系统产生的废水不含铬。 | Anna Bacardit Stefan van der Burgh Jordi Armengol 陈浩 | 2014 | 西部皮革2014，36，16： | 1 |
| 4 | Chinese Journalism and the Academy: the politics and pedagogy of the media显示文摘 | Hugo De Burgh | 2000 | Journalism Studies2000，，4： | 1 |
| 5 | Animal models of spinal muscular atrophy显示文摘 | Monani UR Coovert DD Burghes AHM | 2000 | Hum Mol Genet2000，9，16： | 1 |
| 6 | PXR and CAR nu- clear receptors which play a pivotal role in drug disposition and chemical toxicity 显示文摘 | Stanley L A Hors burgh B C Wolf C R | 2006 | Drug Met Rev2006，38，： | 1 |
| 7 | Defects in mitochondrial clearance predispose human monocytes to interleukin-113 hypersccretion显示文摘 | van der Burgh R Nijhuis L Pervolaraki K | 2014 | J Biol Chem2014，289，8： | 1 |
| 8 | Standardized manual palpation of myofascial trigger points in relation to neck/shoulder pain;the influence of clinical experience on inter-examiner reproducibility显示文摘 | My burgh C Lauridsen HH Larsen AH | 2011 | Man Ther2011，16，2： | 1 |
| 9 | Oak leaves as biosensors of late Neogene and early Pleistocene paleoatmospheric CO2 concentrations 显示文摘 | KURSCHNER W M Van der BURGH J VISSCHER H | 1996 | Mar Micropaleontol1996，27，： | 1 |
| 10 | Long-term follow-up after radiofrequency catheter ablation of ventrieular tachycardia:a successful approach?显示文摘 | Borger van der Burgh AE De Groot NM Van Erven L | 2002 | Journal of Cardiovascular Electroplaysiology2002，13，5： | 1 |
| 11 | Cardiac imaging in a symptomatic patient with multiple coronary artery–left ventricular microfistulae显示文摘 | Marc Hartmann Jan van Es Michel A. Galjee Pieter H. van der Burgh Wieger I. de Bruin Salah A. Said Clemens von Birgelen | 2007 | Heart and Vessels2007，，6： | 1 |
| 12 | Microbiologically corrosion control in a cooling water system显示文摘 | Burgh W D | 1985 | MP 241985，10，： | 1 |
| 13 | Paleoatmospheric signatures in Neogene fossil leaves 显示文摘 | Van der BURGH J VISSCHER H DILCHER D L | 1993 | Science1993，260，： | 1 |
| 14 | Antisense oligonucleotides for the treatment of spinal muscular strophy显示文摘 | Porensky PN Burghes AH | 2013 | Hum Gene Ther2013，24，5： | 1 |
| 15 | Specific ionic effects on weak polyelectrolyte multilaycr formation显示文摘 | KOVACEVIC D VAN DER BURGH S DE KEIZER A | 2003 | Journal of Physical Chemistry B2003，107，： | 1 |
| 16 | On initial boundary value problems for weakly semilinear telegraph equations: Asymptotic theory and application 显示文摘 | Van Horssen W T Van Der Burgh A H P | 1988 | SIAM J Appl Math1988，48，2： | 1 |
| 17 | Let all DNA vote: who are the amyotrophic lateral sclerosis candidates?显示文摘 | Burghes AH Butchbach ME | 2008 | Neurology2008，70，9： | 1 |
| 18 | Antisense oligonucleotides and spinal muscular atrophy: skipping along显示文摘 | Burghes AH McGovem VL | 2010 | 24(15): 1574-15792010，24，15： | 1 |
| 19 | Refined physical map of the spinal muscular atrophy gene (SMA) region at 5q13 based on YAC and cosmid contiguous arrays显示文摘 | Natalie Roy Michael D. Mclean Anne Besner-Johnston Charles Lefebvre Maysoon Salih John D. Carpten Arthur H.M. Burghes Zahra Yaraghi Joh-E Ikeda Robert G. Korneluk Alexander E. Mackenzie | 1995 | Genomics1995，，3： | 1 |
| 20 | 134^th ENMC knternational workshop: outcome measures and treatment of spinal muscular atrophy, 11-13 February 2005, Naarden, the Netherlands 显示文摘 | Bertini E Burghes A Bushby K | 2005 | Neuromuscul Disord2005，15，11： | 1 |
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