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| 1 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 2 | Identification of der (1; 19) (q10; p10) in five oligodendrogliomas suggests mechanism of concurrent lp and 19q loss显示文摘 | Griffin C A Burger P Morsberger L | 2006 | J Neuropathol Exp Neurol2006，65，10： | 1 |
| 3 | Elevated serum inhibin concentrations in postmenopausal women with ovarian tumors显示文摘 | HEALY D L BURGER H G MAMERA P R N | 1993 | N Engl J Med1993，329，： | 1 |
| 4 | The subspace Gaussian mixture model: A structured model for speech recognition 显示文摘 | Povey D Burger L Agarwal M | 2011 | Comput Speech Lang2011，25，2： | 1 |
| 5 | Com- plications of axial lumbar interbody fusion 显示文摘 | LINDLEY E M MCCULLOUGH M A BURGER E L | 2011 | J Neurosurg- Spine2011，3，3： | 1 |
| 6 | Changes in transcrption within the CA1 field of the hippocampus areassociated with age-related spatial learning impairments显示文摘 | Burger C López M C Feller J A | 2007 | Neurobiol Learn Mem2007，87，1： | 1 |
| 7 | Cycle and hor mone changes during perimenopause: the key role of ovarianfunction 显示文摘 | Burger HG Hale GE Dennerstein L | 2008 | Menopause2008，15，41： | 1 |
| 8 | The minor capsid protein VP1 of the autonomous parvovirus minute virus of mice is dispensable for encapsidation of progeny single-stranded DNA but is required for infectivity显示文摘 | TULLIS G E BURGER L R PINTEL D J | 1993 | J Virol1993，69，1： | 1 |
| 9 | The regulation of FSH beta transcription by gonadal steroids:testosterone and estradiol modulation of the activin intracellular signaling pathway显示文摘 | BURGER L L HAISENLEDER D J WOTTON G M | 2007 | Am J Physiol Endocrinol Metab2007，293，1： | 1 |
| 10 | Microbial immobilization of ammoniumand nitrate in relation to ammoniflcation and nitrification rates inorganic and conventional cropping systems 显示文摘 | BURGER M JACKSON L E | 2003 | Soil Biology &Biochemistry2003，35，： | 1 |
| 11 | Predictive value of serum CA 125 levels in patients with persistent or recurrent epithelial o varian cancer or peritoneal cancer treated with bevacizumab on a Gynecologic Oncology Group phase II trial 显示文摘 | Randall L M SiI1M W Burger R A | 2012 | Gynecol Oncol2012，124，56： | 1 |
| 12 | Estimating root respiration microbial respiration in the rbizosphere, and rnot-free soil respira- tion in forest soils 显示文摘 | Kehing D L Burger J A Edwards G S | 1998 | Soil Biology and Biochemistry1998，30，： | 1 |
| 13 | Prevention of inadvertent perioperative hypothermia显示文摘 | Burger L Fitzpatrick J | 2009 | Br J Nurs2009，18，18： | 1 |
| 14 | Estimating root respiration,microbial respiration in the rhizosphree,and root free soil respiration in forest soil显示文摘 | Kelting D L Burger J A Edwards G S | 1998 | Soil Biology and Biochemistry1998，30，7： | 1 |
| 15 | The minor capsid protein VP1 of the autonomous parvovirus minutevirus of mice is dispensable of encapsidation of progeny single-stranded DNA but is required for infectivity显示文摘 | TULLIS G E BURGER L R PINTEL D J | 1993 | J Virol1993，69，1： | 1 |
| 16 | Viral oncopro- teins target the DNA methyltransferases显示文摘 | Burgers WA Blanchon L Pradhan S | 2007 | Oncogene2007，26，11： | 1 |
| 17 | Forkhead box o as a sen- sor, mediator, and regulator of redox signaling 显示文摘 | de Keizer P L Burgering B M Dansen T B | 2011 | Antioxid Redox Signal2011，14，6： | 1 |
| 18 | The role of sensitizing antibody in the neutralization of equine arteritis virus by complement or anti- IgG serum显示文摘 | Radwan A L Burger D | 1973 | Virology1973，3，2： | 1 |
| 19 | Impact of vegetation cover and slope on runoff,erosion, and water quality for field plots on a range of soil and spoil materials on central Queenlands coal mines显示文摘 | Carroll C Merton L Burger P | 2000 | Australian Journal of Soil Research2000，38，2： | 1 |
| 20 | The Contributions of Soil Science to the Development of and Implementation of Criterion and Indicators of Sustainable Forest Management显示文摘 | Burger J A Kelting D L | 1998 | Soil Science Society of America Journal1998，，53： | 1 |
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