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13篇 您的检索式：作者名="Bumbaca"

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		题名	作者	年代	出处	被引量
	1	Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategies显示文摘Despite its good initial response and significant survival benefit in patients with castrationresistant prostate cancer(CRPC), taxane therapy inevitably encounters drug resistance in all patients.Deep understandings of taxane resistant mechanisms can significantly facilitate the development of new therapeutic strategies to overcome taxane resistance and improve CRPC patient survival. Multiple pathways of resistance have been identified as potentially crucial areas of intervention. First, taxane resistant tumor cells typically have mutated microtubule binding sites, varying tubulin isotype expression,and upregulation of efflux transporters. These mechanisms contribute to reducing binding affinity and availability of taxanes. Second, taxane resistant tumors have increased stem cell like characteristics,indicating higher potential for further mutation in response to therapy. Third, the androgen receptor pathway is instrumental in the proliferation of CRPC and multiple hypotheses leading to this pathway reactivation have been reported. The connection of this pathway to the AKT pathway has received significant attention due to the upregulation of phosphorylated AKT in CRPC. This review highlights recent advances in elucidating taxane resistant mechanisms and summarizes potential therapeutic strategies for improved treatment of CRPC.	Brandon Bumbaca Wei Li	2018	Acta Pharmaceutica Sinica B2018，8，4：	4
	2	A hierarchy of self-renewing tumor-initiating cell types in glioblastoma显示文摘	Chen R Nishimura MC Bumbaca SM	2010	Cancer Cell2010，17，4：	1
	3	Physiochemical and biochemical factors influencing the pharmaco- kinetics of antibody therapeutics显示文摘	BUMBACA D ANDREW BOSWELL C FIELDER PJ	2012	AAPS J2012，14，3：	1
	4	Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1):an emphasis on preclinical and clinical catabolism 显示文摘	SHEN B Q BUMBACA D SAAD O	2012	Curr Drug Metab2012，13，7：	1
	5	Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1):an emphasis on preclinical and clinical catabolism显示文摘	SHEN B Q BUMBACA D SAAD O	2012	Curt Drug Metab2012，13，7：	1
	6	Structure of a protein-DNA complex essential for DNA protection in spores of Bacillus species显示文摘	Lee KS Bumbaca D Kosman J	2008	PNAS2008，105，8：	1
	7	A hierarchy of self-renewing tumor-initiating cell types in glioblastoma显示文摘	Chen R Nishimura MC Bumbaca SM	2010	Cancer Cell2010，17，4：	1
	8	Highly specific off - target binding identified and eliminated during the humanization of an anti- body against FGF receptor 4 显示文摘	Bumbaca D Wong A Drake E	2011	MAbs2011，3，：	1
	9	Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants显示文摘	Bien-Ly N Yu Y J Bumbaca D	2014	J Exp Med2014，211，2：	1
	10	A hierarchy of serfrenewing tumorinittiating cell types in glioblastoma显示文摘	Chen R Nishimura M C Bumbaca S M		0，，4：	1
	11	Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4显示文摘	Daniela Bumbaca Anne Wong Elizabeth Drake Arthur E. Reyes II Benjamin C. Lin Jean-Philippe Stephan Luc Desnoyers Ben-Quan Shen Mark S. Dennis	2011	mAbs2011，，4：	1
	12	A hierarchy of self-renewing tumor-initiating cell types in glioblastoma显示文摘	Chen R Nishimura MC Bumbaca SM	2010	Cancer Cell2010，17，4：	1
	13	A hierarchy of self-renewing tumor-initiating cell types in glioblastoma显示文摘	Chen R Nishimura MC Bumbaca SM	2010	Cancer Cell2010，17，4：	1

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