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| 1 | Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps显示文摘AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a 'black box' but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists. | Barbara André Tom Vercauteren Anna M Buchner Murli Krishna Nicholas Ayache Michael B Wallace | 2012 | World Journal of Gastroenterology2012，18，39： | 5 |
| 2 | Time course of eosinophilic myocarditis visualized by cmR显示文摘 | Deb K Djavidani B Buchner S | 2008 | J Cardiovasc Magn Reson2008，10，： | 1 |
| 3 | Double induction strategy for acute myeloid leukemia: the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the German AML cooperative group 显示文摘 | BUCHNER T HIDDEMANN W WORMANN B | 1999 | Blood1999，93，12： | 1 |
| 4 | Carbon nanostructures as multi-functional drug delivery Platforms显示文摘 | Mendes R G Bachmatiuk A Buchner B Cuniberti G Rummeli M H | 2013 | Journal of Materials Chemistry B2013，，1： | 1 |
| 5 | Schwann cell-n於liateddelivery of g!ial cell line-derived neurotrophic factor restoreserectile function after cavernous nerve injury显示文摘 | May F Buchner A Schlenker B | 2013 | Int J Urol2013，20，3： | 1 |
| 6 | Doublt induction strategy for acutcmyeloid leukemia:the effect of high-dose cylarabine with mitoxantrone instead of standard dose cyturadine with daunorubicin and 6-thioguanine:arandomized trial by the German Aml Cooperative Gnup显示文摘 | Buchner T Hiddemann W Wormann B | 1999 | Blood1999，93，12： | 1 |
| 7 | Variety in vegetable and fruit consumption and the risk of gastric and esophageal cancer in the European Prospective Investigation into Cancer and Nutrition显示文摘 | Jeurnink S M Buchner F L Bueno deMesquita H B | | 0，，06： | 1 |
| 8 | The effect of strength and endurance training on gait, balance, fall risk, and health services use in commu- nity-living older adults显示文摘 | Buchner DM Cress ME Lateur B J | 1997 | J Gerontol A Biol Sci Med Sci1997，52，4： | 1 |
| 9 | Quantification of left-to-right shunting in adult congenital heart disease:phase-contrast cine MRI compared with invasive oximetry显示文摘 | Debl K Djavidani B Buchner S | 2009 | Br J Radiol2009，82，977： | 1 |
| 10 | Toward unbiased measurement of conscious and unconscious processes within the process dissociation framework显示文摘 | Buchner A Etdelder E Vaterrodt-Plunnecke B | 1995 | Journal of Experiment Psychology: General1995，124，： | 1 |
| 11 | Over-allocation or abatement? A preliminary analysis of the EU-ETS based on the 2005-2006 emissions Data 显示文摘 | ELLERMAN D BUCHNER B | 2008 | Environmental and Resource Economics2008，，41： | 1 |
| 12 | Double induction strategy for acute myeloid leukemia: the effect of high-dose eytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the German AML Cooperative Group 显示文摘 | Buchner T Hiddemann W Wormann B | 1999 | Blood1999，93，12： | 1 |
| 13 | Double induction strategy for acute myeloid leukemia: The effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: A randomized trial by the German AML Cooperative Group 显示文摘 | Buchner T Hiddemann W Wormann B | 1999 | Blood1999，93，12： | 1 |
| 14 | Improved catalytic performance of hierarchical ZSM-5 synthesized by desilication with surfactants 显示文摘 | SCHMIDTF LOHE M R BUCHNER B | 2013 | Microporous and Mesoporous Materials2013，165，1： | 1 |
| 15 | Acute traumatic primary patel ar dislocation:long-term results comparing conservative and surgical treatment显示文摘 | Buchner M Baudendistel B Sabo D | | 0，，02： | 1 |
| 16 | Toward unbiased measurement of conscious and unconscious memory processes within the process dissociation framework显示文摘 | Erdfilder E Vaterrodt - Plunnecke B | 1995 | Journal of Experimental Psychology: General1995，124，： | 1 |
| 17 | The allocation of European union allowances:lessons,unifying themes and general principles显示文摘 | Buchner B Carraro C Ellerman A D | | 0，，01： | 1 |
| 18 | Learning semantic and visual similarity for endomicrosco-py video retrieval显示文摘 | ANDRfi B VERCAUTEREN T BUCHNER A M | 2012 | Medical Imaging IEEE Transac-tions on2012，31，6： | 1 |
| 19 | Acute myeloid leukemia in adults: is postconsolidation maintenance therapy necessary? 显示文摘 | Buchner T Hiddemann W Wormann B | 2000 | Int J Hematol2000，72，3： | 1 |
| 20 | Age determination of ballpoint pen ink by thermal desorption and gas chromatographymass spectrometry显示文摘 | BGLER J H BUCHNER H DALLMAYER A | 2008 | Journal of forensic sciences2008，53，4： | 1 |
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