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| 1 | Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis显示文摘AIM:To determine the effect of non-selective cyclooxygenase (COX) inhibitors,selective COX-2 inhibitors and nitric oxide (NO)-releasing aspirin in the healing of ulcerative colitis.METHODS:Rats with 2,4,6 trinitrobenzenesulfonic acid (TNBS)-induced colitis received intragastric (ig) treatment with vehicle,aspirin (ASA) (a nonselective COX inhibitor),celecoxib (a selective COX-2 inhibitor) or NO-releasing ASA for a period of ten days.The area of colonic lesions,colonic blood flow (CBF),myeloperoxidase (MPO) activity and expression of proinflammatory markers COX-2,inducible form of nitric oxide synthase (iNOS),IL-1β and tumor necrosis factor (TNF)-α were assessed.The effects of glyceryl trinitrate (GTN),a NO donor,and 2-(4-carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazolyl-1-oxy-3-oxide,onopotassium salt (carboxy-PTIO),a NO scavenger,administered without and with ASA or NO-ASA,and the involvement of capsaicin-sensitive afferent nerves in the mechanism of healing the experimental colitis was also determined.RESULTS:Rats with colitis developed macroscopic and microscopic colonic lesions accompanied by a significant decrease in the CBF,a significant rise in colonic weight,MPO activity and plasma IL-1β and TNF-α levels.These effects were aggravated by ASA and 5-(4-chlorophenyl)-1-(4-methoxyphenyl)3-(trifluoromethyl)-1H-pyrazole (SC-560),but not celecoxib and counteracted by concurrent treatment with a synthetic prostaglandin E 2 (PGE 2) analog.Treatment with NO-ASA dose-dependently accelerated colonic healing followed by a rise in plasma NO x content and CBF,suppression of MPO and downregulation of COX-2,iNOS,IL-1β and TNF-α mRNAs.Treatment with GTN,the NO donor,significantly inhibited the ASA-induced colonic lesions and increased CBF,while carboxy-PTIO or capsaicin-denervation counteracted the NO-ASAinduced improvement of colonic healing and the accompanying increase in the CBF.These effects were restored by co-treatment with calcitonin gene related peptide (CGRP) and NO-ASA in capsaicin-denervated animals.CONCLUSION:NO-releasing ASA,in contrast to ASA,COX-1 inhibitors,and SC-560,accelerated the healing of colitis via a mechanism involving NO mediated improvement of microcirculation and activation of sensory nerves releasing CGRP. | Malgorzata Zwolinska-Wcislo Tomasz Brzozowski Agata Ptak-Belowska Aneta Targosz Katarzyna Urbanczyk Slawomir Kwiecien Zbigniew Sliwowski | 2011 | World Journal of Gastroenterology2011，17，36： | 2 |
| 2 | Expression of epidermal growth factor-alpha after exposure of rat gastric mucosa to stress显示文摘 | Emst H Brzozowski T | 1996 | Scand J Gastroenterol1996，31，3： | 1 |
| 3 | Epidermal growth and transforming growth factor alpha:Role in protection and healing of gastric mucosal lesions显示文摘 | Konturek PC Konturek Sj Brzozowski T | 1995 | Eur J Gast roenterol Hepatol1995，7，10： | 1 |
| 4 | Preparation and characterization of the recombinant selenomethionine analogue of insulin-like growth factor-Ⅰ 显示文摘 | De Bree FM Brzozowski AM Gellerfors P | 1998 | Protein Expr Purif1998，13，3： | 1 |
| 5 | Role of salivary glands and epidermal growth factor (EGF) in gastric secretion and mucosal integrity in rats exposed to stress显示文摘 | Konturek S J Brzozowski T Konturek P K | 1991 | Regul Peptides1991，32，： | 1 |
| 6 | Pathogenesis of Helicobacter pylori infection 显示文摘 | Hatakeyama M Brzozowski T | 2006 | Helicobacter2006，11，1： | 1 |
| 7 | Role of gastric acidecretion in progression of acute gastric erosions induced by ischemiarepeffusion into gastric ulcers 显示文摘 | Brzozowski T Konturek PC Konturek S J | 2000 | Eur Pharmacol2000，398，1： | 1 |
| 8 | Role of polyamines and prostaglandins in gastroprotective action of epidermal growth factor against ethanol injury显示文摘 | Brzozowski T Majka J Garlicki J | 1991 | J Clin Gastroenterol1991，31，1： | 1 |
| 9 | Role of brain-gut axis in healing of gastric ulcers 显示文摘 | Konturek P C Brzozowski B Burnat G | 2004 | J Physiol Pharmacol2004，55，1： | 1 |
| 10 | Role of prostaglandins in gastroprotection and gastric adaptation 显示文摘 | Brzozowski T Konturek PC Konturek SJ | 2005 | J Physiol Pharmacol2005，565，： | 1 |
| 11 | Increased serum level of N‐terminal Pro‐B‐type natriuretic peptide as a possible biomarker of cardiovascular risk in psoriatic patients显示文摘 | A. Pietrzak J. Bartosinska R. Blaszczyk G. Chodorowska W. Brzozowski J. Hercogova H. Donica T. Lotti | 2015 | J Eur Acad Dermatol Venereol2015，，： | 1 |
| 12 | Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage显示文摘 | Brzozowski T Konturek SJ | 1998 | Eur J Pharmacol1998，342，1： | 1 |
| 13 | Structure of a pullulanase from Bacillus acidopuUulyticus 显示文摘 | Turkenburg J P Brzozowski A M Svendsen A | 2009 | Proteins2009，76，2： | 1 |
| 14 | Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epi- thelial cells 显示文摘 | Targosz A Brzozowski T Pierzchalski P | 2012 | Inflammation Research2012，61，9： | 1 |
| 15 | Classic NSAID and selective cyclooxygenase(Cox)-1 and Cox-2 inhibitors in healing of chronic gastric ulcers显示文摘 | Brzozowski T Konturek PC Konturek SJ | | 0，，05： | 1 |
| 16 | Synthesis, structural characterization and antitumor activity of novel 2,4-diamino-1,3,5-triazine derivatives显示文摘 | Z. Brzozowski F. S?czewski M. Gdaniec | 2000 | European Journal of Medicinal Chemistry2000，，12： | 1 |
| 17 | Epidermal growth factor, polyamines, and prostaglandins in healing of stress-induced gastric lesions in rats显示文摘 | T. Brzozowski PhD Prof. Dr. S. J. Konturek MD J. Majka MD A. Dembinski MD D. Drozdowicz PhD | 1993 | Digestive Diseases and Sciences1993，，2： | 1 |
| 18 | Derivatives of regular expressions显示文摘 | Brzozowski J A | 1964 | Journal of the ACM1964，11，4： | 1 |
| 19 | Role of leptin in the stomach and the pancreas 显示文摘 | Konturek PC Konturek S J Brzozowski T | 2001 | Physiology - Paris2001，95，16： | 1 |
| 20 | Influence of Nb5+and Sb3+dopants on the defect profile,PTCR effect and GB-BLcharacteristic s of BaTiO3 ceramics显示文摘 | Castro M S | 2004 | Journal of the European Ceramic Society2004，24，： | 1 |
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