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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Safety and efficacy of protease inhibitors to treat hepatitis C after liver transplantation: A multicenter experience显示文摘 | Audrey Coilly Bruno Roche Jér?me Dumortier Vincent Leroy Danielle Botta-Fridlund Sylvie Radenne Georges-Philippe Pageaux Si-Nafaa Si-Ahmed Olivier Guillaud Teresa Maria Antonini Stéphanie Ha?m-Boukobza Anne-Marie Roque-Afonso Didier Samuel Jean-Charles Du | 2014 | Journal of Hepatology2014，，1： | 2 |
| 3 | Correlationof biomarker expression in colonic mucosa with diseasephenotype in crohn’s disease and ulcerative colitis 显示文摘 | Bruno ME Rogier EW Arsenescu RI | 2015 | DigDis Sci2015，60，10： | 1 |
| 4 | Signature biomarkersin Crohn’s disease: toward a molecular classification 显示文摘 | Arsenescu R Bruno ME Rogier EW | 2008 | Mucosal Immunol2008，1，5： | 1 |
| 5 | Pure endoscopic endonasal odontoidectomy : anatomical study 显示文摘 | Messina A Bruno ME Cavallo LM | 2007 | Neurosurg Rev2007，30，3： | 1 |
| 6 | A multi-locus plastid phylogenetic analysis of the pantropical genus Diospyros (Ebenaceae), with an emphasis on the radiation and biogeographic origins of the New Caledonian endemic species显示文摘 | Sutee Duangjai Rosabelle Samuel Jér?me Munzinger Félix Forest Bruno Walln?fer Michael H.J. Barfuss Gunter Fischer Mark W. Chase | 2009 | Molecular Phylogenetics and Evolution2009，，3： | 1 |
| 7 | Carbonation of Ca-bearing silicates, the case of wollastonite: Experimental investigations and kinetic modeling显示文摘 | Damien Daval Isabelle Martinez Jér?me Corvisier Nathaniel Findling Bruno Goffé Fran?ois Guyot | 2009 | Chemical Geology2009，，1： | 1 |
| 8 | Alterations in the rat serum proteome during liver injury from acetarninophen exposure显示文摘 | Merrick BA Bruno ME Madenspaeher JH | 2006 | J Phar- macol Exp Ther2006，318，2： | 1 |
| 9 | Differential gene expression profiling in whole blood during acule systemic inflammation in lipopolysaccharide -treated rats显示文摘 | Fannin RD Auman JT Bruno ME | 2005 | Physiol Genomics2005，21，1： | 1 |
| 10 | The pathophysiology, diagnosis and prognosis of adrenocortical tumors revisited by transcriptome analyses显示文摘 | Guillaume Assié Marine Guillaud-Bataille Bruno Ragazzon Xavier Bertagna Jér?me Bertherat Eric Clauser | 2010 | Trends in Endocrinology & Metabolism2010，，5： | 1 |
| 11 | Identification and Cloning of a New Calmodulin-like Protein from Human Epidermis显示文摘 | Dominique Bernard Lucie Simonetti | 2000 | J Biol Chem2000，275，12： | 1 |
| 12 | Unraveling the at- tentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection显示文摘 | Sarter M Hasselmo ME Bruno JP | 2005 | Brain Res Brain Res Rev2005，48，1： | 1 |
| 13 | Impact of Lactobacillus reuteri supplementation on anti-Helicobacter pylori Levofloxacin-based secondline therapy显示文摘 | Ojetti V Bruno G Ainora ME | 2012 | Gastroenterol Res Pract2012，2012，74： | 1 |
| 14 | Stiffness of capacitive and conduit arteries :prognostic significance for end-stage re- nal disease patients显示文摘 | Bruno P Sylvain JM Safer ME | 2005 | Hypertension2005，45，： | 1 |
| 15 | Prospective evaluation of transnasal esophagogastroduodenoscopy: feasibility and study on performance and tolerance显示文摘 | Jér?me Dumortier Thierry Ponchon Jean-Yves Scoazec Bruno Moulinier Fred Zarka Pierre Paliard René Lambert | 1999 | Gastrointestinal Endoscopy1999，，3： | 1 |
| 16 | Regulation of thepolymeric immunoglobulin receptor by the classical andalternative NF-fcB pathways in intestinal epithelial cells显示文摘 | Bruno ME Frantz AL’Rogier EW | 2011 | Mucosal Immunol2011，4，4： | 1 |
| 17 | Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-KB pathways in intestinal epithelial cells显示文摘 | Bruno ME Franta AL Rogier EW | 2011 | Mucosal Immunol2011，4，4： | 1 |
| 18 | Structure–activity relationships of urotensin II and URP显示文摘 | Jér?me Leprince David Chatenet Christophe Dubessy Alain Fournier Bruno Pfeiffer Elizabeth Scalbert Pierre Renard Pierre Pacaud Hassan Oulyadi Isabelle Ségalas-Milazzo Laure Guilhaudis Daniel Davoust Marie-Christine Tonon Hubert Vaudry | 2007 | Peptides2007，，5： | 1 |
| 19 | HIV-associated pulmonary arterial hypertension: survival and prognostic factors in the modern therapeutic era显示文摘 | Bruno Degano Mathilde Guillaume Laurent Savale David Montani Xavier Ja?s Azzedine Yaici Jér?me Le Pavec Marc Humbert Gérald Simonneau Olivier Sitbon | 2010 | AIDS2010，，1： | 1 |
| 20 | Signature biomarkers in Crnhn disease:toward a molecular classification 显示文摘 | Arsenescu R Bruno ME Rogier EW | 2008 | Mucosal Im- muno12008，1，： | 1 |
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